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Lyra Therapeutics
(OTC:LYRA)
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Rating:41Neutral
Price Target:
$0.19
▼(-7.00% Downside)
Action:Upgraded
Date:10/09/26
The score is primarily constrained by weak financial performance (minimal and declining revenue, persistent losses, ongoing cash burn, and negative equity), which elevates financing risk. Technicals are mixed-to-weak with a negative MACD and the stock below longer-term averages despite neutral RSI. Valuation support is limited due to negative earnings (negative P/E) and no dividend yield.
Positive Factors
Localized drug-delivery platform
Lyra’s localized, sustained-release platform is designed to improve treatment duration and tissue targeting versus systemic or short-duration topical options. If clinical development succeeds, this differentiated delivery approach could support product adoption and create a durable position in chronic ENT care.
Negative Factors
Sharp revenue decline and limited scale
Lyra has not demonstrated commercial scale, with very small revenue declining sharply in 2025 and no sustainable profitability on the current base. This limits internally generated funding, makes operating results volatile, and leaves future value heavily dependent on successful development and commercialization.
Read all positive and negative factors
Positive Factors
Negative Factors
Localized drug-delivery platform
Lyra’s localized, sustained-release platform is designed to improve treatment duration and tissue targeting versus systemic or short-duration topical options. If clinical development succeeds, this differentiated delivery approach could support product adoption and create a durable position in chronic ENT care.
Read all positive factors
Lyra Therapeutics (LYRA) vs. SPDR S&P 500 ETF (SPY)
Market Cap
$337.23K
Dividend YieldN/A
Average Volume (3M)691.00
Price to Earnings (P/E)―
Beta (1Y)4.78
Revenue Growth-74.05%
EPS Growth73.08%
CountryUS
Employees27
SectorHealthcare
Sector Strength45
IndustryBiotechnology
Share Statistics
EPS (TTM)-18.62
Shares Outstanding1,774,882
10 Day Avg. Volume1,124
30 Day Avg. Volume691
Financial Highlights & Ratios
PEG Ratio>-0.01
Price to Book (P/B)-4.46
Price to Sales (P/S)120.22
P/FCF Ratio-1.65
Enterprise Value/Market Cap58.81
Enterprise Value/Revenue49.83
Enterprise Value/Gross Profit49.83
Enterprise Value/Ebitda-0.71
Forecast
1Y Price TargetN/A
Price Target UpsideN/A
Rating ConsensusN/A
Number of Analyst Covering0
EPS Forecast (FY)-7.02
Revenue Forecast (FY)$700.00K
Lyra Therapeutics Business Overview & Revenue Model
Company Description
Lyra Therapeutics, Inc. operates as a clinical-stage biotechnology company, primarily focused on the creation and commercialization of anti-inflammatory treatments for individuals suffering from chronic rhinosinusitis (CRS). The company's unique t...
How the Company Makes Money
As a clinical-stage biotechnology company, Lyra Therapeutics has historically not generated material recurring revenue from commercial product sales because it does not have widely disclosed, ongoing marketed products. Therefore, its ability to fu...
Lyra Therapeutics Financial Statement Overview
Summary
Income Statement
18
Very Negative
Balance Sheet
22
Negative
Cash Flow
20
Very Negative
| Breakdown | Dec 2025 | Dec 2024 | Dec 2023 | Dec 2022 | Dec 2021 |
|---|---|---|---|---|---|
Income Statement | |||||
| Total Revenue | 398.00K | 1.53M | 1.56M | 1.36M | 285.00K |
| Gross Profit | 398.00K | 1.53M | 1.56M | 1.36M | -29.41M |
| EBITDA | -29.09M | -60.26M | -65.25M | -53.92M | -42.61M |
| Net Income | -28.92M | -93.44M | -62.68M | -55.28M | -43.51M |
Balance Sheet | |||||
| Total Assets | 36.11M | 66.35M | 142.60M | 109.97M | 54.87M |
| Cash, Cash Equivalents and Short-Term Investments | 15.89M | 40.58M | 102.75M | 97.89M | 45.75M |
| Total Debt | 30.26M | 34.38M | 26.88M | 4.18M | 1.45M |
| Total Liabilities | 46.83M | 54.75M | 53.18M | 29.21M | 20.55M |
| Stockholders Equity | -10.72M | 11.59M | 89.42M | 80.75M | 34.32M |
Cash Flow | |||||
| Free Cash Flow | -28.98M | -72.35M | -64.35M | -43.55M | -29.20M |
| Operating Cash Flow | -28.86M | -70.01M | -63.30M | -43.38M | -25.82M |
| Investing Cash Flow | -98.00K | 80.31M | -12.58M | -65.01M | -3.38M |
| Financing Cash Flow | 4.27M | 8.53M | 65.69M | 96.26M | 359.00K |
Lyra Therapeutics Technical Analysis
Negative
0.20
Price Trends
0.18
Positive
0.39
Negative
0.88
Negative
Market Momentum
>-0.01
Negative
50.09
Neutral
98.99
Negative
Evaluating momentum and price trends is crucial in stock analysis to make informed investment decisions. For LYRA, the sentiment is Negative. The current price of 0.2 is above the 20-day moving average (MA) of 0.17, above the 50-day MA of 0.18, and below the 200-day MA of 0.88, indicating a neutral trend. The MACD of >-0.01 indicates Negative momentum. The RSI at 50.09 is Neutral, neither overbought nor oversold. The STOCH value of 98.99 is Negative, not indicating any strong overbought or oversold conditions. Overall, these indicators collectively point to a Negative sentiment for LYRA.
Lyra Therapeutics Risk Analysis
Lyra Therapeutics disclosed 24 risk factors in its most recent earnings report. Lyra Therapeutics reported the most risks in the "Finance & Corporate" category.
Finance & Corporate - Financial and accounting risks. Risks related to the execution of corporate activity and strategy
Latest Risks Added 0 New Risks
Lyra Therapeutics Peers Comparison
UnderperformOutperform
Sector (51)
Name | Overall Rating | Market Cap | P/E Ratio | ROE | Dividend Yield | Revenue Growth | EPS Growth |
|---|---|---|---|---|---|---|---|
51 Neutral | $7.86B | -0.30 | -43.30% | 2.27% | 22.53% | -2.21% | |
49 Neutral | $12.08M | -0.39 | -126.23% | 0.06% | 12.79% | 37.93% | |
49 Neutral | $29.97M | -0.03 | -58.08% | ― | ― | 86.74% | |
43 Neutral | $2.80M | -0.82 | -34.23% | ― | ― | 85.52% | |
42 Neutral | $2.73M | >-0.01 | -563.11% | ― | ― | 98.10% | |
41 Neutral | $337.23K | -0.01 | 455.31% | ― | -74.05% | 73.08% | |
39 Underperform | $8.20M | -0.60 | -269.02% | ― | ― | ― |
* Healthcare Sector Average
LYRA
Lyra Therapeutics
0.19
-5.84
-96.85%
XTLB
XTL Biopharmaceuticals Sponsored ADR
2.02
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-57.92%
MBIO
Mustang Bio
0.37
-1.13
-75.33%
BOLT
Bolt Biotherapeutics
6.27
0.03
0.48%
RNAZ
TransCode Therapeutics
1.77
-11.37
-86.53%
SLXN
Silexion Therapeutics
0.19
-34.51
-99.46%
Glossary
BuyA stock rated as a "Buy" is expected to perform better than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock is likely to deliver higher returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
HoldA stock rated as a "Hold" is expected to perform in line with the overall market or a specific benchmark. This rating indicates that the stock is neither particularly compelling nor unfavorable for investment. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
SellA stock rated as a "Sell" is expected to perform worse than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock may deliver lower returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
Disclaimer
This AI Analyst Stock Report is automatically generated by our AI systems using advanced algorithms and publicly available financial, technical, and market data. While the information provided aims to be accurate and insightful, it is intended for informational purposes only and should not be considered financial advice. Any content created by an AI (Artificial Intelligence) system may contain inaccuracies and/or contain errors. Investing in stocks carries inherent risks, and past performance is not indicative of future results. This report does not account for your personal financial circumstances, objectives, or risk tolerance. Always conduct your own research or consult with a qualified financial advisor before making investment decisions. The analysis and recommendations provided are based on historical and current data and may not fully reflect future market conditions or unexpected developments. Neither the creators of this report nor its affiliated entities guarantee the accuracy, completeness, or reliability of the information presented. Use this report at your own discretion and risk.