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Modalis Therapeutics Corporation (4883) AI Stock Analysis

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JP:4883

Modalis Therapeutics Corporation

(TSE/TYO:4883)

Select Model
Rating:45.5Neutral
Price Target:JPY 29.00▼(-3.33% Downside)
Action:upgraded
Date:11/14/26

The overall score of 45.5 reflects a high-risk, pre-revenue biotechnology company. The most significant factor is the weak financial performance, characterized by no revenue, substantial net losses, and a high cash burn rate that is eroding the company's debt-free balance sheet. Technical analysis shows the stock in a longer-term downtrend despite a recent short-term bounce. Traditional valuation metrics are inapplicable due to negative earnings. The company's future is entirely dependent on the success of its clinical programs and its ability to secure additional funding.

Positive Factors
Proprietary platformA proprietary gene-regulation platform gives Modalis a differentiated scientific foundation and the potential to address diseases through mechanisms beyond conventional drug discovery. If research produces viable candidates, this technology base could support multiple programs and partnership opportunities over time.
Negative Factors
Minimal revenueThe absence of meaningful revenue shows that Modalis has not yet established a recurring commercial or collaboration income base. Until programs generate partnerships, milestones, or approved products, the company remains dependent on external financing to support its operating model.

Modalis Therapeutics Corporation (4883) vs. iShares MSCI Japan ETF (EWJ)

-80%-60%-40%-20%0%20%40%JP:4883-55.22%EWJ+16.06%Dec '25Jan '26Feb '26Mar '26Apr '26May '26Jun '26Jul '26Aug '26Sep '26Oct '26Nov '26
Market Cap
JPY 3.48B
Dividend Yield
―
Average Volume (3M)
1.80M
Price to Earnings (P/E)
-1.5
Beta (1Y)
0.89
Revenue Growth
―
EPS Growth
25.34%
Country
Japan
Employees
17
Sector
General
Sector Strength
55
Industry
Biotechnology

Modalis Therapeutics Corporation Business Overview & Revenue Model

Company Description

Modalis Therapeutics Corporation focuses on discovering and developing treatments for severe genetic conditions. The company utilizes its proprietary CRISPR-GNDM technology to create therapies by controlling gene expression through the epigenetic mod...

How the Company Makes Money

Modalis Therapeutics primarily seeks to generate revenue through the development and monetization of its drug discovery platform and pipeline. Potential revenue streams for a clinical-stage biotech of this type typically include (i) upfront payments,...

Modalis Therapeutics Corporation Financial Statement Overview

Summary

Financial performance is weak, typical of a pre-revenue biotech. The Income Statement (Score 15) shows no revenue and widening losses. The Cash Flow Statement (Score 10) reflects a high and increasing cash burn. The Balance Sheet (Score 35) is a relative strength with no debt, but equity is eroding. The overall financial health is precarious, heavily dependent on future funding.

Income Statement

15Very Negative

Balance Sheet

35Negative

Cash Flow

10Very Negative
Financial statement breakdown
BreakdownTTMDec 2025Dec 2024Dec 2023Dec 2022Dec 2021
Income Statement
Total Revenue000040.50M1.10M
Gross Profit000-731.00K-83.17M1.10M
EBITDA-2.17B-2.21B-2.15B-2.37B-2.58B-667.55M
Net Income-2.05B-2.15B-1.32B-2.39B-2.70B-738.96M
Balance Sheet
Total Assets3.14B2.96B3.69B2.03B3.13B6.07B
Cash, Cash Equivalents and Short-Term Investments3.02B2.81B3.58B1.88B2.93B4.94B
Total Debt270.00M00412.50M00
Total Liabilities673.71M170.94M143.47M645.50M188.60M519.92M
Stockholders Equity2.46B2.79B3.55B1.38B2.94B5.55B
Cash Flow
Free Cash Flow0-2.12B-1.43B-2.29B-2.09B-854.58M
Operating Cash Flow0-2.12B-1.43B-2.25B-1.90B-747.47M
Investing Cash Flow0-2.57M-188.00K-39.70M-185.72M171.56M
Financing Cash Flow01.35B3.04B1.22B63.68M72.63M

Modalis Therapeutics Corporation Technical Analysis

Technical Analysis SentimentNeutral
Last Price30.00

Price Trends

50DMA31.00Negative
100DMA31.79Negative
200DMA43.79Negative

Market Momentum

MACD-0.77Negative
RSI53.97Neutral
STOCH79.37Neutral

Evaluating momentum and price trends is crucial in stock analysis to make informed investment decisions. For JP:4883, the sentiment is Neutral. The current price of 30.00 is above the 20-day moving average (MA) of 28.00, below the 50-day MA of 31.00, and below the 200-day MA of 43.79, indicating a neutral trend. The MACD of -0.77 indicates Negative momentum. The RSI at 53.97 is Neutral, neither overbought nor oversold. The STOCH value of 79.37 is Neutral, not indicating any strong overbought or oversold conditions. Overall, these indicators collectively point to a Neutral sentiment for JP:4883.

Modalis Therapeutics Corporation Peers Comparison

Overall Rating

UnderperformOutperform
Sector (55)

Financial Indicators

JP:4883 against its peers
NameOverall RatingMarket CapP/E RatioROEDividend YieldRevenue GrowthEPS Growth
JP:4574JP:457469NeutralJPY 13.27B19.21―1.25%13.30%66.38%
Sector *55Neutral$6.65B3.83-15.92%6.20%10.91%7.18%
JP:4539JP:453947NeutralJPY 5.52B-11.50―3.30%0.31%-194.72%
JP:4883JP:488346NeutralJPY 3.13B-1.45―――25.34%
JP:4892JP:489242NeutralJPY 5.30B-6.32――364.72%18.43%
JP:4597JP:459739UnderperformJPY 6.55B-8.22-53.67%―109.82%61.98%
JP:4582JP:458238UnderperformJPY 5.25B-0.65――-30.58%6.93%

* General Sector Average

Performance Comparison

-50%0%50%JP:4883JP:4597JP:4539JP:4574JP:4582JP:4892Dec '25Jan '26Feb '26Mar '26Apr '26May '26Jun '26Jul '26Aug '26Sep '26Oct '26Nov '26
JP:4883 and its peers over the selected period
Show on chartTickerCompany NamePriceChange% Change
JP:4883Modalis Therapeutics Corporation30.00-37.00-55.22%
JP:4597Solasia Pharma KK25.00-8.00-24.24%
JP:4539Nippon Chemiphar Co., Ltd.1515.0034.182.31%
JP:4574Taiko Pharmaceutical Co., Ltd.263.00-27.00-9.31%
JP:4582Symbio Pharmaceuticals Limited59.00-47.00-44.34%
JP:4892Cyfuse Biomedical K.K.514.00-67.00-11.53%

Modalis Therapeutics Corporation Corporate Events

Modalis Designates Exercise Suspension for 19th Series Rights

Nov 12, 2026

Modalis Therapeutics Corporation is listed on the Tokyo Stock Exchange under code 4883. It notified EVO FUND, the allottee of its 19th Series stock acquisition rights, that it designated an exercise suspension period from November 19 through December...

Modalis: 5 Million Yen Foreign-Exchange Gain Recorded

Nov 12, 2026

Modalis Therapeutics Corporation recorded 5 million yen in foreign-exchange gains as non-operating income for the nine months ended September 30, 2026. The gains arose mainly from foreign-currency-denominated assets and liabilities held by the Group....

Modalis Therapeutics’ Third-Quarter 2026 Business and Financial Report

Nov 12, 2026

Modalis Therapeutics Corporation is identified with TSE ticker 4883, but the release text provided does not describe its industry, products, services, or market focus. The document is titled the company’s third-quarter 2026 business and financial rep...

Modalis Reports Nine-Month 2026 Financial Results

Nov 12, 2026

For the nine months ended September 30, 2026, Modalis Therapeutics Corporation reported operating revenue as “-,” an operating loss of ¥1,686 million compared with ¥1,815 million a year earlier, and a loss attributable to owners of the parent of ¥1,6...

Modalis Therapeutics Issues Further Corrections to Interim Financial Results

Aug 14, 2026

Modalis Therapeutics Corporation announced further corrections to its consolidated financial results for the six months ended June 30, 2026, under Japanese GAAP. The adjustments affect explanatory materials linked to second-quarter balance sheet, fin...

Modalis Revises Interim Results After R&D Expense Timing Error

Aug 14, 2026

Modalis Therapeutics Corporation reported consolidated financial results for the six months ended June 30, 2026, under Japanese GAAP, showing continued operating losses, negative ordinary income, and a basic loss per share, but maintaining a solid eq...

Glossary
BuyA stock rated as a "Buy" is expected to perform better than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock is likely to deliver higher returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
HoldA stock rated as a "Hold" is expected to perform in line with the overall market or a specific benchmark. This rating indicates that the stock is neither particularly compelling nor unfavorable for investment. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
SellA stock rated as a "Sell" is expected to perform worse than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock may deliver lower returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.

Disclaimer

This AI Analyst Stock Report is automatically generated by our AI systems using advanced algorithms and publicly available financial, technical, and market data. While the information provided aims to be accurate and insightful, it is intended for informational purposes only and should not be considered financial advice. Any content created by an AI (Artificial Intelligence) system may contain inaccuracies and/or contain errors. Investing in stocks carries inherent risks, and past performance is not indicative of future results. This report does not account for your personal financial circumstances, objectives, or risk tolerance. Always conduct your own research or consult with a qualified financial advisor before making investment decisions. The analysis and recommendations provided are based on historical and current data and may not fully reflect future market conditions or unexpected developments. Neither the creators of this report nor its affiliated entities guarantee the accuracy, completeness, or reliability of the information presented. Use this report at your own discretion and risk.

Date of analysis: Nov 14, 2026