Vertex Pharmaceuticals stock analysis
Vertex Pharmaceuticals (0QZU) Share Price & Analysis
0QZU Stock Chart & Stats
- Day’s Range
- $538.00 - $559.46
- 52-Week Range
- $410.40 - $579.00
- Previous Close
- $543.23
- Volume
- N/A
- Average Volume (3M)
- 865
- Market Cap
- $138.69B
- Enterprise Value
- $133.59B
- Total Cash (Recent Filing)
- $6.30B
- Total Debt (Recent Filing)
- $6.48B
- Price to Earnings (P/E)
- 34.8
- Beta
- 0.72
- Next Earnings
- Feb 09, 2027 (Est.)
- EPS Estimate
- 4.2
- Next Dividend Ex-Date
- N/A
- Dividend Yield
- N/A
Bulls Say, Bears Say
Bulls Say
CF Franchise Growth
The CF franchise continues to produce recurring demand while ALYFTREK expands treatment coverage and international access. Ongoing patient uptake, label expansion, and reimbursement progress support durable revenue generation from Vertex’s established commercial foundation.
Commercial Diversification
Growth beyond CF is becoming commercially meaningful, reducing reliance on a single franchise over time. Progress across gene therapy, pain treatment, and endocrinology creates multiple potential revenue streams and supports broader long-term earnings durability.
Profitability And Liquidity
Very high margins, strong quarterly profitability, and substantial liquidity give Vertex resources to fund research, launches, and business development. This financial capacity supports resilience and allows continued investment while newer products scale commercially.
Bears Say
Higher Acquisition Leverage
The Crinetics financing materially increased debt and adds recurring interest obligations to the cost base. Although Vertex retains substantial cash generation, higher leverage reduces balance-sheet conservatism and makes sustained operating execution more important.
Rising Operating Costs
Higher spending can support launches and pipeline development, but it also raises the earnings hurdle for Vertex’s expanding portfolio. Acquisition-related costs and integration spending may constrain margin progression until commercial growth generates sufficient operating leverage.
Softening Cash Conversion
Vertex still generates substantial cash, but weaker recent free-cash-flow momentum and conversion indicate less efficient translation of reported earnings into liquidity. If sustained, this could limit flexibility for investment, acquisitions, debt reduction, or shareholder returns.
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Vertex Pharmaceuticals Stock Smart Score
Company Description
Vertex Pharmaceuticals
Vertex Pharmaceuticals Incorporated is a leading biotechnology firm primarily focused on the discovery, advancement, and marketing of innovative treatments, particularly for cystic fibrosis (CF). The company offers a range of approved medications for CF patients, including SYMDEKO/SYMKEVI, ORKAMBI, and KALYDECO, which target specific mutations within the cystic fibrosis transmembrane conductance regulator gene. Additionally, they provide TRIKAFTA for individuals with CF aged six years and older who possess at least one F508del mutation. Beyond its established CF therapies, Vertex maintains a robust and diverse clinical pipeline. This includes VX-864, currently in Phase 2 for alpha-1 antitrypsin (AAT) deficiency; VX-147, also in Phase 2, addressing APOL1-mediated focal segmental glomerulosclerosis (FSGS) and other serious kidney conditions; VX-880, a potential treatment for Type 1 Diabetes undergoing Phase 1/2 trials; VX-548, a NaV1.8 inhibitor in Phase 2 for various forms of acute, neuropathic, and musculoskeletal pain; and CTX001, which is in Phase 3 development for severe sickle cell disease (SCD) and transfusion-dependent beta-thalassemia (TDT). The company distributes its pharmaceutical products through specialty pharmacies and distributors across the United States, while international sales are facilitated via a network of specialty distributors, retail chains, hospitals, and clinics. Vertex also engages in numerous strategic collaborations with partners such as Affinia Therapeutics, Arbor Biotechnologies, CRISPR Therapeutics, Kymera Therapeutics, Mammoth Biosciences, Moderna, Obsidian Therapeutics, Skyhawk Therapeutics, Ribometrix, Genomics plc, Merck KGaA, and X-Chem. Established in 1989, Vertex Pharmaceuticals is headquartered in Boston, Massachusetts.
- Sector
- Healthcare
- Industry
- Biotechnology
- CEO
- Reshma Kewalramani
- Employees
- 6,400
- Website
- www.vrtx.com
- Address
- 50 Northern Avenue, Boston, MA, 02210, US
Vertex Pharmaceuticals (0QZU) Earnings & Revenues
0QZU Company Deck
0QZU Earnings Call
Earnings Call SentimentPositive
The call was strongly positive, with 12% year-over-year revenue growth, raised full-year revenue guidance, strong commercial momentum across ALYFTREK, CASGEVY, JOURNAVX, and Palsonify, substantial pipeline advancement, and readiness for the povitacept IgAN launch. The main challenges were higher operating and financing costs related to the Crinetics acquisition, temporary JOURNAVX gross-to-net pressure, and the lack of sweat-chloride improvement in the VX-828 dual-combination cohort, but these were outweighed by the reported commercial and clinical progress.
View all GB:0QZU earnings summaries0QZU Net sales Breakdown
- 85.93% TRIKAFTA/KAFTRIO
- 6.98% ALYFTREK
- 6.83% Other product revenues
- 0.26% Other revenues
0QZU Stock 12 Month Forecast
Average Price Target
Technical Analysis
Overall Consensus
| Indicator | Bullish | Neutral | Bearish |
|---|---|---|---|
| Overall Consensus | 13 | 5 | 4 |
| Technical Analysis | 4 | 5 | 1 |
| Moving Averages | 9 | 0 | 3 |











