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Alnylam Pharma (0HD2) Drug Pipeline

Drug pipeline
Drug NameConditionStageStatusStudy NameTrial Start DateArticle
Aln-App, MivelsiranDown Syndrome-Associated Alzheimer's Disease (Ds-Ad)Phase IINot Yet RecruitingA Study to Evaluate Mivelsiran in Adult Participants With Early-Stage Down Syndrome-Associated Alzheimer's Disease (DS-AD)Jun 04, 2026
Aln-6222ObesityPhase IRecruitingA Study to Evaluate ALN-6222 in Participants With ObesityMay 29, 2026―
Aln-6400Von Willebrand Disease (Vwd), Heavy Menstrual Bleeding (Hmb)Phase IINot Yet RecruitingHMBeacon: A Phase 2 Study to Evaluate ALN-6400 in Adult and Adolescent Female Patients With VWD and HMBMay 04, 2026
Zilebesiran, Aln-Agt01 RvrHypertensionPhase IIRecruitingA Study to Evaluate ALN-AGT01 RVR in Adult Patients With Mild to Moderate Hypertension Pretreated With ZilebesiranApr 22, 2026
Aln-4324Type 2 Diabetes Mellitus (T2dm)Phase IIRecruitingA Study to Evaluate ALN-4324 on Insulin Sensitivity in Adults With Type 2 Diabetes MellitusMar 06, 2026
Tirzepatide, Aln-2232Obesityphase1AndPhase2RecruitingA Study to Evaluate ALN-2232 in Participants With ObesityMar 06, 2026
Aln-4915Healthy VolunteersPhase IRecruitingA Study to Evaluate ALN-4915 in Adult Healthy VolunteersFeb 26, 2026
Aln-4285Healthy VolunteersPhase IRecruitingA Study to Evaluate ALN-4285 in Adult Healthy VolunteersDec 10, 2025
Vutrisiran, NucresiranHereditary Transthyretin-Mediated Amyloidosis With Polyneuropathy, Hattr-PnPhase IIIRecruitingTRITON-PN: A Study to Evaluate the Efficacy and Safety of Nucresiran in Patients With Hereditary Transthyretin Amyloidosis With PolyneuropathyOct 29, 2025
Aln-5288Alzheimer's DiseasePhase IRecruitingA Study to Evaluate ALN-5288 in Patients With Alzheimer's DiseaseOct 06, 2025

FAQ

What are the FDA phases for drug approval?
The FDA approval process for new drugs is divided into several phases: a. Preclinical testing b. Phase 1 – Safety and dosage c. Phase 2 – Effectiveness and side effects d. Phase 3 – Confirmation of effectiveness, monitoring of adverse reactions, and comparison with existing treatments e. Phase 4 – Post-marketing studies to track long-term safety and effectiveness
What is a clinical trial?
A clinical trial is a carefully designed study in which researchers test a drug, treatment, or medical device in people to evaluate its safety, effectiveness, and potential side effects. These trials are essential for determining whether a new treatment should be approved for widespread use.
What drugs does Alnylam Pharmaceuticals (GB:0HD2) have in its pipeline
Alnylam Pharma GB:0HD2 is currently developing the following drugs: Aln-App, Mivelsiran, Aln-6222, Aln-6400, Zilebesiran, Aln-Agt01 Rvr, Aln-4324, Tirzepatide, Aln-2232, Aln-4915, Aln-4285, Vutrisiran, Nucresiran, Aln-5288, Zilebesiran, Sterile Normal Saline, Nucresiran, Vutrisiran, Aln-Agt01 Rvr, Pembrolizumab, Aln-Bcat, Aln-Htt02, Aln-App, Aln-Khk, Aln-Ttrsc04, Aln-Xdh, Lumasiran, Amlodipine, Indapamide, Olmesartan, Zilebesiran, Aln-Agt01, Pozelimab, Cemdisiran, Aln-Hsd, Vir-2218, Vir-2218, Pegylated Interferon-Alfa 2A, Sterile Normal Saline, Vutrisiran, Patisiran, Irbesartan, Aln-Agt01, Cemdisiran, Aln-Aat02. These drug candidates are in various stages of clinical development as the company works toward FDA approval.