Amicus (FOLD) AI Stock Analysis

• Market Cap: $1.86B
• Dividend Yield: N/A
• Average Volume (3M): 4.75M
• Price to Earnings (P/E): ―
• Beta (1Y): 0.70
• Revenue Growth: 28.25%
• EPS Growth: 80.86%
• Country: US
• Employees: 499
• Sector: Healthcare
• Sector Strength: 53
• Industry: Biotechnology
• EPS (TTM): -0.07
• Shares Outstanding: 307,930,970
• 10 Day Avg. Volume: 4,324,420
• 30 Day Avg. Volume: 4,750,819
• PEG Ratio: 1.37
• Price to Book (P/B): 28.68
• Price to Sales (P/S): 0.00
• P/FCF Ratio: -20.72
• Enterprise Value/Market Cap: 2.06
• Enterprise Value/Revenue: 1.90
• Enterprise Value/Gross Profit: 7.76
• Enterprise Value/Ebitda: 114.44
• 1Y Price Target: $17.00
• Price Target Upside: 193.10% Upside
• Rating Consensus: Strong Buy
• Number of Analyst Covering: 7

• Rating: 62 Neutral
• Price Target: $7.00 ▲(20.69%Upside)

Amicus Therapeutics shows promising revenue growth and strategic developments. However, challenges with profitability, high leverage, and current bearish technical indicators are concerns. The positive outlook from the earnings call and strategic corporate events provide optimism for future growth, balancing the current financial and technical challenges.

Positive Factors

Financial Position

Amicus ended the first quarter with a strong financial position and does not anticipate any near-term impact from this.

Market Opportunity

There are currently no FDA-approved treatments for FSGS, creating a potential multi-blockbuster opportunity for FOLD with rare disease pricing.

Market Share

Galafold holds over 65% of the global amendable market share with an opportunity to move higher as mature markets are reaching 85-90% of market share.

Negative Factors

Earnings

Amicus' first quarter print came in below expectations and the stock is under pressure after lowering Pombiliti/Opfolda guidance.

Regulatory and Development Risks

FOLD faces risks common to the biotech industry, including development, regulatory, and manufacturing challenges.

Revenue

Total revenue guidance for FY25 was lowered due to an unexpectedly higher UK VPAG rebate rate.

Amicus Business Overview & Revenue Model

Company Description

Amicus Therapeutics, Inc., a biotechnology company, focuses on discovering, developing, and delivering medicines for rare diseases. Its commercial product and product candidates include Galafold, an oral precision medicine for the treatment of adults with a confirmed diagnosis of Fabry disease and an amenable galactosidase alpha gene variant based on in vitro assay data. It also develops AT-GAA, a novel treatment paradigm for Pompe disease; enzyme replacement therapies for Pompe diseases; CLN3, which is in Phase 1/2 clinical study to evaluate the safety and efficacy of a single intrathecal administration of an AAV serotype AT-GTX-502 gene therapy in patients with CLN3; and CDKL5, a gene on the X-chromosome encoding the CDKL5 protein that regulates the expression of essential proteins for normal brain development. The company has collaboration and license agreements with Nationwide Children's Hospital; University of Pennsylvania; and GlaxoSmithKline. Amicus Therapeutics, Inc. was incorporated in 2002 and is headquartered in Philadelphia, Pennsylvania.

How the Company Makes Money

Amicus makes money through the development and commercialization of its pharmaceutical products, particularly targeting rare and orphan diseases. The company generates revenue primarily through product sales, especially from its flagship drug Galafold (migalastat), which is used to treat Fabry disease. Additionally, Amicus may also earn income from partnerships and collaborations with other pharmaceutical companies, which can include licensing agreements, milestone payments, and royalties. These strategic partnerships are significant contributors to its earnings, along with government grants or incentives for developing treatments for rare diseases.

Amicus Financial Statement Overview

Summary

Amicus exhibits strong revenue growth and gross profit margins. However, persistent net losses and high debt levels indicate financial instability. While cash flow metrics show improvement, the company faces challenges in achieving profitability and maintaining financial flexibility.

Income Statement

The company shows a positive revenue growth trend with a TTM (Trailing-Twelve-Months) revenue of $543.1 million, up from $528.3 million in the previous annual period. Gross profit margin remains strong at approximately 91%. However, the net profit margin is negative due to consistent net losses, indicating profitability challenges. EBIT and EBITDA margins have improved but remain low, suggesting limited operational efficiency.

Balance Sheet

The company's debt-to-equity ratio is relatively high, indicating significant leverage, which could pose a financial risk. The equity ratio stands at 24.5%, showing a moderate proportion of equity financing. The return on equity is negative due to net losses, highlighting the company's struggle to generate returns for shareholders.

Cash Flow

The free cash flow has turned positive in the TTM period, showing improvement from the previous annual period. The operating cash flow to net income ratio is positive, indicating some level of cash generation from operations. However, the free cash flow to net income ratio remains low, pointing to challenges in converting earnings into cash flow.

Breakdown
TTM	Dec 2024	Dec 2023	Dec 2022	Dec 2021	Dec 2020
Income Statement		Total Revenue
543.14M	528.29M	399.36M	329.23M	305.51M	260.89M
	Gross Profit
494.22M	475.35M	362.03M	290.63M	271.05M	229.84M
	EBIT
38.60M	24.88M	-73.49M	-204.43M	-199.92M	-243.85M
	EBITDA
53.63M	29.39M	-92.08M	-199.58M	-202.87M	-242.98M
	Net Income Common Stockholders
-29.37M	-56.11M	-151.58M	-236.57M	-250.46M	-276.85M
Balance Sheet		Cash, Cash Equivalents and Short-Term Investments
250.57M	249.95M	286.20M	293.60M	482.50M	483.27M
	Total Assets
789.84M	785.03M	777.88M	724.17M	905.14M	886.52M
	Total Debt
443.47M	443.64M	445.06M	452.12M	440.13M	441.73M
	Net Debt
261.81M	229.89M	198.06M	303.31M	194.93M	278.49M
	Total Liabilities
596.28M	590.99M	617.71M	601.12M	597.77M	600.14M
	Stockholders Equity
193.56M	194.04M	160.17M	123.05M	307.37M	286.38M
Cash Flow		Free Cash Flow
1.61M	-37.44M	-76.53M	-170.34M	-206.38M	-236.52M
	Operating Cash Flow
3.56M	-33.89M	-69.09M	-166.57M	-202.49M	-233.29M
	Investing Cash Flow
-40.96M	-560.00K	98.06M	92.32M	78.76M	-13.58M
	Financing Cash Flow
6.73M	5.12M	61.68M	-7.46M	212.07M	262.86M

Amicus Technical Analysis

• Technical Analysis Sentiment: Negative
• Last Price: 5.80
• 50DMA: Negative
• 100DMA: Negative
• 200DMA: Negative
• MACD: Negative
• RSI: Neutral
• STOCH: Neutral

Evaluating momentum and price trends is crucial in stock analysis to make informed investment decisions. For FOLD, the sentiment is Negative. The current price of 5.8 is below the 20-day moving average (MA) of 6.15, below the 50-day MA of 6.46, and below the 200-day MA of 9.11, indicating a bearish trend. The MACD of -0.16 indicates Negative momentum. The RSI at 36.96 is Neutral, neither overbought nor oversold. The STOCH value of 23.41 is Neutral, not indicating any strong overbought or oversold conditions. Overall, these indicators collectively point to a Negative sentiment for FOLD.

Amicus Peers Comparison

Name	Overall Rating	Market Cap	P/E Ratio	ROE	Dividend Yield	Revenue Growth	EPS Growth
FOLD	62 Neutral	$1.86B	―	-18.12%	―	28.25%	80.86%
Sector *	54 Neutral	$5.34B	3.36	-45.10%	3.39%	16.81%	-0.03%
CRNX	53 Neutral	$2.92B	―	-30.84%	―	―	-1.20%
APLS	52 Neutral	$2.30B	―	-103.82%	―	48.04%	48.16%
SRRK	50 Neutral	$3.05B	―	-106.71%	―	―	-22.34%
RARE	48 Neutral	$3.51B	―	-386.33%	―	33.46%	26.72%
IMVT	45 Neutral	$2.65B	―	-62.46%	―	―	-43.10%

Amicus Corporate Events

Amicus Stockholders Approve Directors and Equity Plan

At the 2025 Annual Meeting of Stockholders held on June 5, 2025, Amicus‘s stockholders elected four Class III directors for a three-year term and approved the 2025 Equity Incentive Plan. They also ratified Ernst & Young LLP as the independent registered public accounting firm for the fiscal year ending December 31, 2025, and approved the executive compensation on an advisory basis.

The most recent analyst rating on (FOLD) stock is a Buy with a $20.00 price target. To see the full list of analyst forecasts on Amicus stock, see the FOLD Stock Forecast page.

Amicus Secures License for DMX-200 Development

On April 30, 2025, Amicus Therapeutics entered into a license agreement with Dimerix Bioscience, granting Amicus exclusive rights to develop, manufacture, and commercialize Dimerix’s drug candidate DMX-200 in the United States for Focal Segmental Glomerulosclerosis (FSGS) and other indications. This agreement, effective May 1, 2025, includes a $30 million upfront payment and potential milestone payments totaling up to $560 million. Dimerix will continue funding the ongoing pivotal Phase 3 study for DMX-200, while Amicus will handle regulatory submissions and commercialization in the U.S. This collaboration aims to bring a transformative treatment to patients with FSGS, a rare kidney disease with limited treatment options, enhancing Amicus’s portfolio in the rare disease market.