Clinical Milestone — AVA6103 First Patient Dosed
First patient dosed in FOCUS-01 Phase I (AVA6103) on time in March 2026; multicenter US-focused trial enrolling 6 advanced cancers with initial clinical data committed by end of 2026 (late Q4).
Encouraging AVA6000 Clinical Progress and Regulatory Outcome
AVA6000 (Gen One) reported preliminary efficacy and safety in salivary gland cancer; Phase Ib continues with a recommended dose for expansion (RDE) defined at 310 mg/m2; favorable cardiac safety data resulted in lifting of the lifetime maximum doxorubicin dose constraint.
Strong Preclinical Differentiation vs ADCs
Preclinical translational data show up to ~40x higher tumor Cmax for released exatecan (AVA6103) versus comparator ADC payloads and ~3x higher tumor selectivity index (tumor vs plasma) — key mechanistic advantages that may translate clinically.
Increased R&D Investment Reflecting Pipeline Focus
Research & development spend rose to GBP 18.8m in FY2025 from GBP 14.3m prior year, a ~31.5% increase, reflecting focused investment in the proprietary pre|CISION peptide drug conjugate platform and therapeutic programs.
Improved Cost Efficiency in Administration and Cash Outflows
Administrative expenses fell to ~GBP 10m from GBP 12m (~16.7% reduction). Net operating cash outflows improved to GBP 22.64m from GBP 24.94m (~9.2% reduction year-on-year).
Fundraising and Cash Position
Raised GBP 32.5m over the last 18 months (including an oversubscribed placing/subscription of GBP 10m); cash at end-April 2026 was GBP 16.4m, extending runway into early Q1 2027 (projection excludes partnering income).
Pipeline & IP Expansion — Gen Two and Gen Three Progress
Updated in vivo data for Gen Two (AVA6103) and Gen Three (AVA6207 dual-payload) at AACR; continued growth of IP estate protecting sustained release and dual-payload technologies; dual-payload capability is a novel differentiator.