Ctx112
Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disease, Stiff-Person Syndrome, Progressive Multiple Sclerosis (Pms), Neuromyelitis Optica, Autoimmune Encephalitis
Phase I/II
Not Yet Recruiting
A Safety and Efficacy Study Evaluating CTX112 in Subjects With Refractory Neurologic Autoimmune Disease
Aug 12, 2026
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Ctx310
Hypertriglyceridemia, Homozygous Familial Hypercholesterolemia (Hofh), Hypercholesterolaemia, Dyslipidemias, Metabolic Disease, Severe Hypertriglyceridemia (Shtg), Cardiovascular, Lipid Disorder, Heterozygous Familial Hypercholesterolemia (Hefh), Mixed Hyperlipemia
Phase I
Recruiting
A Safety and Tolerability Trial Evaluating CTX310 in Participants With Refractory Dyslipidemias
Mar 18, 2026
Ctx112
Lupus Erythematosus, Systemic, Lupus Nephritis, Systemic Sclerosis, Myositis, Sle (Systemic Lupus), Inflammatory Myopathy, Idiopathic, Diffuse Cutaneous Systemic Sclerosis
Phase I
Recruiting
A Safety and Efficacy Study Evaluating CTX112 in Adult Subjects With Refractory Autoimmune Disease
Mar 25, 2025
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Ctx131
Acute Myeloid Leukemia, T Cell Lymphoma, B Cell Lymphoma
Phase I/II
Recruiting
A Safety and Efficacy Study Evaluating CTX131 in Adult Subjects With Relapsed/Refractory Hematologic Malignancies
Jun 21, 2024
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Ctx001
Hemoglobinopathies, Sickle Cell Disease, Hydroxyurea Failure, Hydroxyurea Intolerance, Hematological Diseases
Phase III
Active Not Recruiting
Evaluation of Safety and Efficacy of CTX001 in Pediatric Participants With Severe Sickle Cell Disease (SCD)
Apr 07, 2022
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Ctx001
Hemoglobinopathies, Beta-Thalassemia, Genetic Diseases, Inborn, Hematologic Diseases, Thalassemia
Phase III
Active Not Recruiting
Evaluation of Safety and Efficacy of CTX001 in Pediatric Participants With Transfusion-Dependent β-Thalassemia (TDT)
Apr 07, 2022
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Ctx130
T Cell Lymphoma
Phase I
Terminated
A Safety and Efficacy Study Evaluating CTX130 in Subjects With Relapsed or Refractory T or B Cell Malignancies (COBALT-LYM)
Aug 04, 2020
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Ctx130
Renal Cell Carcinoma
Phase I
Terminated
A Safety and Efficacy Study Evaluating CTX130 in Subjects With Relapsed or Refractory Renal Cell Carcinoma (COBALT-RCC)
Jun 16, 2020
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Ctx120
Multiple Myeloma
Phase I
Terminated
A Safety and Efficacy Study Evaluating CTX120 in Subjects With Relapsed or Refractory Multiple Myeloma
Jan 24, 2020
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FAQ
What are the FDA phases for drug approval?
The FDA approval process for new drugs is divided into several phases:
a. Preclinical testing
b. Phase 1 – Safety and dosage
c. Phase 2 – Effectiveness and side effects
d. Phase 3 – Confirmation of effectiveness, monitoring of adverse reactions, and comparison with existing treatments
e. Phase 4 – Post-marketing studies to track long-term safety and effectiveness
a. Preclinical testing
b. Phase 1 – Safety and dosage
c. Phase 2 – Effectiveness and side effects
d. Phase 3 – Confirmation of effectiveness, monitoring of adverse reactions, and comparison with existing treatments
e. Phase 4 – Post-marketing studies to track long-term safety and effectiveness
What is a clinical trial?
A clinical trial is a carefully designed study in which researchers test a drug, treatment, or medical device in people to evaluate its safety, effectiveness, and potential side effects. These trials are essential for determining whether a new treatment should be approved for widespread use.
What drugs does Crispr Therapeutics AG (1CG) have in its pipeline
1CG is currently developing the following drugs: Ctx112, Ctx112, Ctx310. These drug candidates are in various stages of clinical development as the company works toward FDA approval.