Commercial BarriersKOLs warned the commercial barriers may be high, with most feeling that SGLT2s would likely receive a Class 1 recommendation in the next guidelines.
Financial PerformanceThe deals' related dilution and increased long-term operating expenses trajectory resulted in a lower price target.
Safety ConcernsSafety was more problematic, where beyond high rates of GI issues, one patient’s LVEF dropped below 50%, raising the prospect of a potential REMS with negative commercial read-throughs.