uniQure (UQ1) Stock Price & Analysis
UQ1 Stock Chart & Stats
- Day’s Range
- N/A
- 52-Week Range
- N/A
- Previous Close
- N/A
- Volume
- N/A
- Average Volume (3M)
- N/A
- Market Cap
- CHF 1.42B
- Enterprise Value
- CHF 2.79B
- Total Cash (Recent Filing)
- CHF 810.34M
- Total Debt (Recent Filing)
- CHF 62.83M
- Price to Earnings (P/E)
- ―
- Beta
- N/A
- Next Earnings
- Nov 04, 2026 (Est.)
- EPS Estimate
- -0.75
- Next Dividend Ex-Date
- N/A
- Dividend Yield
- N/A
Bulls Say, Bears Say
Bulls Say
AMT-130 Regulatory Progress
Submitting AMT-130 applications in both the U.S. and U.K. marks a major transition from clinical development toward potential commercialization. The therapy’s Breakthrough, RMAT and Fast Track designations may support regulatory interaction and strengthen uniQure’s position in central nervous system gene therapy.
Long-term AMT-130 Efficacy Signal
Durable follow-up showing continued disease-progression slowing is strategically important because it supports AMT-130’s potential disease-modifying profile beyond an early clinical signal. If regulators accept the evidence, the data could underpin approval, commercial differentiation and broader platform credibility.
Extended Financial Runway
A cash position sufficient to fund operations into 2030 gives uniQure time to pursue confirmatory development and prepare for potential commercialization without immediate financing pressure. This strengthens strategic flexibility and reduces the risk that near-term capital needs disrupt clinical or regulatory execution.
Bears Say
Persistent Cash Burn And Deep Losses
The company remains far from self-funded operations, with substantial operating and free-cash-flow losses relative to its small revenue base. Continued investment in clinical programs and commercialization therefore depends on existing capital, future financing or collaboration proceeds, leaving execution sensitive to spending and timing.
AMT-191 Dose-limiting Liver Toxicity
The AMT-191 dosing pause interrupts development at the mid- and high-dose levels and requires an FDA-agreed monitoring and management plan. Although the events resolved with immunosuppression, additional safety work could delay dose optimization, increase development complexity and weaken the program’s near-term value.
AMT-130 Confirmatory-trial Execution Burden
Accelerated approval would not eliminate the need for rapid, substantial confirmatory execution. Aligning the randomized standard-of-care-controlled trial and advancing it toward enrollment around approval creates operational pressure, adds spending requirements and leaves continued commercial progress dependent on trial delivery.
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uniQure Stock Smart Score
Company Description
uniQure
uniQure N.V. develops treatments for patients suffering from rare and other devastating diseases in the United States. The company offers HEMGENIX that allows people living with hemophilia B to produce factor IX, which can lower the risk of bleeding. Its lead product candidate is AMT-130, a gene therapy candidate, which is in phase I/II clinical study for the treatment of Huntington’s disease. The company also develops AMT-260, which is in phase I/IIa clinical trial for the treatment of mesial temporal lobe epilepsy; AMT-162, which is in phase I/IIa clinical trial to treat superoxide dismutase enzyme-amyotrophic lateral sclerosis; and AMT-191, an investigational gene therapy candidate which is in phase I/IIa clinical trial for the treatment of fabry disease. It has a licensing agreement with Apic Bio to develop, manufacture, and commercialize intrathecally administered investigational gene therapy for ALS caused by mutations in SOD-1; and development and commercial supply agreement with CLS Bhering. uniQure N.V. was founded in 1998 and is headquartered in Amsterdam, the Netherlands.
- Sector
- Healthcare
- Industry
- Biotechnology
- CEO
- Matthew C. Kapusta
- Employees
- 221
- Website
- www.uniqure.com
- Address
- Paasheuvelweg 25, Amsterdam, NH, 1105 BP, NL
uniQure (UQ1) Earnings & Revenues
UQ1 Earnings Call
Earnings Call SentimentPositive
Overall the call conveyed strong positive momentum: regulatory progress (FDA alignment on using 3-year data as the basis for an accelerated BLA), an on-track BLA/MAA submission timeline, upcoming 4-year AMT-130 data, encouraging early efficacy and biological signals in AMT-260 and AMT-191, and a materially strengthened balance sheet with ~$810M cash supporting operations into 2030. Notable challenges include a pause in higher-dose AMT-191 dosing after Grade 3 LFTs (dose-limiting toxicity), mixed early efficacy in the AMT-260 low-dose cohort, increased SG&A to fund commercialization (near-term burn), and the operational/regulatory requirement to have the confirmatory trial well underway at the time of any accelerated approval. Taken together, the positives (regulatory clarity, data momentum, cash runway, early signals) outweigh the manageable clinical and execution risks identified.
View all CH:UQ1 earnings summaries