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Starpharma Holdings Limited (SPL) AI Stock Analysis

AU:SPL

Starpharma Holdings Limited

(ASX:SPL)

Select Model
Rating:43Neutral
Price Target:AUD 0.42â–¼(-4.60% Downside)
Action:reiterated
Date:10/21/26

The score is held down primarily by weak financial performance (ongoing losses and negative free cash flow, despite improved 2026 cash burn) and a bearish technical trend (price below all key moving averages with soft momentum). Valuation provides limited support due to the negative P/E and no indicated dividend yield.

Positive Factors
Debt ReductionMaterial debt reduction lowers financial risk and reduces the burden of interest and refinancing obligations. This gives Starpharma greater resilience while it develops its dendrimer-based products, although continued losses mean the balance-sheet benefit must be preserved.
Negative Factors
Persistent LossesSustained operating and net losses show that Starpharma has not yet established a self-sustaining earnings model. Continued losses can consume capital, restrict investment flexibility, and make future progress dependent on achieving stronger revenue scale or materially improving operating costs.

Starpharma Holdings Limited (SPL) vs. iShares MSCI Australia ETF (EWA)

-25%0%25%50%75%100%125%150%175%AU:SPL+40.19%EWA+15.36%Dec '25Jan '26Feb '26Mar '26Apr '26May '26Jun '26Jul '26Aug '26Sep '26Oct '26
Market Cap
AUD 158.31M
Dividend Yield
―
Average Volume (3M)
2.69M
Price to Earnings (P/E)
-26.3
Beta (1Y)
1.66
Revenue Growth
145.32%
EPS Growth
25.75%
Country
Australia
Employees
50
Sector
Healthcare
Sector Strength
51
Industry
Biotechnology

Starpharma Holdings Limited Business Overview & Revenue Model

Company Description

Starpharma Holdings Limited is a biopharmaceutical enterprise focused on the research, development, and global commercialization of dendrimer-based products for the pharmaceutical, life sciences, and other industries. Its current offerings include Vi...

Starpharma Holdings Limited Financial Statement Overview

Summary

Financials are weak overall: Income Statement (34) reflects volatile revenue and ongoing operating/net losses, and Cash Flow (28) shows persistent negative operating and free cash flow despite improved burn in 2026. Balance Sheet (62) is a relative strength with sharply reduced debt, but equity has eroded materially over time, increasing medium-term funding risk.

Income Statement

34Negative

Balance Sheet

62Positive

Cash Flow

28Negative
Financial statement breakdown
BreakdownTTMJun 2026Jun 2025Jun 2024Jun 2023Jun 2022
Income Statement
Total Revenue12.05M12.05M4.91M8.29M2.94M4.68M
Gross Profit10.39M10.39M3.69M7.66M1.22M1.91M
EBITDA-18.32M-18.32M-10.93M-9.63M-22.08M-22.34M
Net Income-7.46M-7.46M-9.99M-8.16M-15.64M-16.15M
Balance Sheet
Total Assets19.02M19.02M25.42M36.81M52.09M66.17M
Cash, Cash Equivalents and Short-Term Investments11.02M11.02M15.41M23.36M35.18M49.92M
Total Debt707.00K707.00K2.40M3.53M8.27M8.19M
Total Liabilities5.24M5.24M6.42M8.70M17.27M17.78M
Stockholders Equity13.78M13.78M19.00M28.12M34.81M48.39M
Cash Flow
Free Cash Flow-3.50M-3.50M-6.80M-7.07M-14.15M-14.00M
Operating Cash Flow-3.21M-3.21M-6.76M-6.98M-13.53M-13.16M
Investing Cash Flow-259.00K-259.00K-42.00K-89.00K-610.00K-836.00K
Financing Cash Flow-876.00K-876.00K-1.13M-4.75M-695.00K3.23M

Starpharma Holdings Limited Technical Analysis

Technical Analysis SentimentNegative
Last Price0.43

Price Trends

50DMA0.72Negative
100DMA0.72Negative
200DMA0.63Negative

Market Momentum

MACD-0.10Positive
RSI23.87Positive
STOCH5.28Positive

Evaluating momentum and price trends is crucial in stock analysis to make informed investment decisions. For AU:SPL, the sentiment is Negative. The current price of 0.43 is below the 20-day moving average (MA) of 0.65, below the 50-day MA of 0.72, and below the 200-day MA of 0.63, indicating a bearish trend. The MACD of -0.10 indicates Positive momentum. The RSI at 23.87 is Positive, neither overbought nor oversold. The STOCH value of 5.28 is Positive, not indicating any strong overbought or oversold conditions. Overall, these indicators collectively point to a Negative sentiment for AU:SPL.

Starpharma Holdings Limited Peers Comparison

Overall Rating

UnderperformOutperform
Sector (51)

Financial Indicators

AU:SPL against its peers
NameOverall RatingMarket CapP/E RatioROEDividend YieldRevenue GrowthEPS Growth
Sector *51Neutral$7.86B-0.30-43.30%2.27%22.53%-2.21%
AU:RCEAU:RCE46NeutralAUD 110.10M-6.9584.67%――42.51%
AU:DXBAU:DXB44NeutralAUD 126.08M-4.22362.74%―-22.13%-108.82%
AU:SPLAU:SPL43NeutralAUD 217.31M-26.32-42.35%―145.32%25.75%
AU:BOTAU:BOT41NeutralAUD 27.63M-0.31-118.74%―499.47%31.20%
AU:ADOAU:ADO38UnderperformAUD 52.24M-11.43-77.75%―-51.74%24.00%
AU:IMMAU:IMM38UnderperformAUD 33.90M-0.43-98.86%――-27.73%

* Healthcare Sector Average

Performance Comparison

0%100%AU:SPLAU:IMMAU:DXBAU:ADOAU:BOTAU:RCEDec '25Jan '26Feb '26Mar '26Apr '26May '26Jun '26Jul '26Aug '26Sep '26Oct '26
AU:SPL and its peers over the selected period
Show on chartTickerCompany NamePriceChange% Change
AU:SPLStarpharma Holdings Limited0.450.1238.04%
AU:IMMImmutep Ltd0.02-0.25-91.48%
AU:DXBDimerix Limited0.21-0.28-57.14%
AU:ADOAnteoTech Ltd0.020.000.00%
AU:BOTBotanix Pharmaceuticals Limited0.01-0.12-92.31%
AU:RCERecce Pharmaceuticals Ltd.0.36-0.05-11.11%

Starpharma Holdings Limited Corporate Events

Starpharma relocates Melbourne headquarters as dendrimer portfolio advances

Oct 23, 2026

Starpharma Holdings Limited, an Australian biotechnology group listed on the ASX and U.S. OTC markets, develops dendrimer-based medical products aimed at improving outcomes for patients with serious illnesses such as cancer. Its operations span clini...

Starpharma Secures $3.5 Million R&D Tax Incentive to Support Oncology Pipeline

Oct 21, 2026

Starpharma has received $3.5 million under the Australian Federal Government’s Research and Development Tax Incentive program, providing non-dilutive funding to support its pipeline of dendrimer-based therapeutics. Management emphasised that th...

Starpharma Tightens Grip on Petalion as Majority Owner in FAP-Targeted Cancer Program

Oct 21, 2026

Starpharma has provided investors with a new presentation and webinar outlining recent changes to the ownership structure of Petalion Therapeutics, its UK-based partner focused on a FAP-targeted dendrimer-drug conjugate for cancer. The company confir...

Starpharma sets 2026 AGM and outlines board leadership transition

Oct 6, 2026

Starpharma has scheduled its 2026 Annual General Meeting for 6 November in Melbourne, where the CEO and outgoing Chair will review the company’s operational and financial performance for the year to 30 June 2026. The hybrid meeting format will...

Starpharma Director’s Performance Rights Lapse After Targets Missed

Oct 4, 2026

Starpharma Holdings Limited has disclosed a change in the interests of director Cheryl Maley, reporting the lapse of 702,768 performance rights after performance criteria were not met. Following this change, Maley continues to hold 141,667 ordinary s...

Starpharma Seeks ASX Quotation for 2.68 Million New Shares

Oct 4, 2026

Starpharma Holdings Limited has applied for quotation of 2,684,166 new ordinary fully paid shares on the ASX, with an issue date of 7 September 2026. The securities arise from the exercise of options or conversion of other convertible instruments, ex...

Starpharma Reports Lapse of 2.2 Million Performance Rights

Oct 4, 2026

Starpharma Holdings Limited has reported a change in its issued capital following the lapse of 2,215,046 performance rights, recorded under the ASX security code SPLAK. These conditional rights ceased on 30 September 2026 after the company confirmed...

Starpharma Reshapes Board Leadership to Back Oncology and Global Growth Push

Oct 1, 2026

Starpharma has announced a planned leadership transition, with long-serving chair Rob Thomas AO to retire as chair at the conclusion of the November 2026 AGM after 12 years in the role, while remaining on the board as a non-executive director subject...

UBS Group AG Withdraws as Substantial Shareholder in Starpharma

Sep 25, 2026

UBS Group AG and its related bodies corporate have notified Starpharma Holdings Limited that they ceased to be a substantial shareholder in the company as of 23 September 2026. The change in UBS’s relevant interest reduces the presence of a maj...

UBS exits substantial holder position in Starpharma

Sep 15, 2026

UBS Group AG and its related bodies corporate have notified Starpharma Holdings Limited that they have ceased to be a substantial shareholder in the company as of 11 September 2026. The change reflects a reduction in UBS’s relevant interest in...

Starpharma sets 2026 AGM date and flags board nomination deadline

Sep 15, 2026

Starpharma has set the date for its 2026 Annual General Meeting, confirming it will take place on Friday, 6 November 2026 in Melbourne, with formal details to follow in a Notice of Meeting in early October. The company will again release the chair&#8...

S&P Dow Jones Indices Unveils September S&P/ASX Rebalance

Sep 4, 2026

S&P Dow Jones Indices has announced the September 2026 quarterly rebalance of the S&P/ASX indices, with changes effective before trading opens on September 21. The S&P/ASX 20 will remain unchanged, while the S&P/ASX 50, 100, 200, and...

UBS Group Ceases to Be Substantial Shareholder in Starpharma

Aug 31, 2026

UBS Group AG and its related bodies corporate have notified Starpharma Holdings that they ceased to be a substantial shareholder in the company as of 27 August 2026, following changes in their relevant interest in Starpharma’s voting securities...

Starpharma Highlights Patient-Focused Dendrimer Strategy in Annual Report

Aug 26, 2026

Starpharma’s latest annual report underscores its strategic focus on deploying dendrimer technology to deliver meaningful clinical benefits for patients with significant diseases such as cancer. The document highlights the company’s long-...

Starpharma Boosts Revenue on Genentech Deal While Deepening R&D Spend

Aug 26, 2026

Starpharma reported a sharp increase in revenue to $12.05 million for the year ended 30 June 2026, up 145% from the prior year, largely driven by an $8.34 million upfront payment from a collaboration and licence agreement with Genentech. Despite high...

UBS Group AG Drops Below Substantial Holding in Starpharma

Aug 19, 2026

UBS Group AG and its related bodies corporate have ceased to be a substantial shareholder in Starpharma Holdings Limited as of 17 August 2026, according to a regulatory notice. The change reflects a reduction in UBS’s voting interest below the...

Starpharma Director Increases Stake Through Entitlement Offer

Aug 13, 2026

Starpharma Holdings Limited has reported a change in the securities holdings of director Robert B. Thomas, in accordance with ASX disclosure rules. The filing outlines his direct and indirect interests in the company’s ordinary shares through p...

Starpharma Director Increases Indirect Shareholding via Entitlement Offer

Aug 13, 2026

Starpharma Holdings has disclosed a change in the interests of director Ms Lynda Cheng, who holds shares indirectly via Zula Pty Ltd as trustee for the Allen Family account. The filing details her participation in the company’s recent pro rata...

Starpharma Director Increases Indirect Shareholding via Entitlement Offer

Aug 13, 2026

Starpharma Holdings Limited has disclosed a change in the interests of director Dr Jeff Davies, indicating an increase in his indirect holding of company shares through Deroda Enterprises Pty Ltd as trustee for the DRD Family Trust. The transaction r...

Starpharma Director Increases Shareholding via Entitlement Offer

Aug 13, 2026

Starpharma Holdings Limited has disclosed a change in the interests of director Cheryl Maley, who increased her direct holding of ordinary shares through participation in the company’s pro rata renounceable entitlement offer. Maley acquired 16,...

Starpharma Seeks ASX Quotation for 56 Million New Shares

Aug 11, 2026

Starpharma Holdings Limited has applied for quotation on the ASX of 56,126,514 new ordinary fully paid shares under the code SPL, with an issue date of 11 August 2026. The new securities arise from previously announced transactions and will expand th...

Starpharma raises $32 million in heavily supported entitlement offer to fund oncology pipeline

Aug 11, 2026

Starpharma Holdings Limited has successfully completed a fully underwritten 1-for-7.5 renounceable pro rata entitlement offer, raising $32 million before costs. The offer received approximately 99% take-up from existing shareholders, with strong dema...

Glossary
BuyA stock rated as a "Buy" is expected to perform better than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock is likely to deliver higher returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
HoldA stock rated as a "Hold" is expected to perform in line with the overall market or a specific benchmark. This rating indicates that the stock is neither particularly compelling nor unfavorable for investment. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
SellA stock rated as a "Sell" is expected to perform worse than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock may deliver lower returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.

Disclaimer

This AI Analyst Stock Report is automatically generated by our AI systems using advanced algorithms and publicly available financial, technical, and market data. While the information provided aims to be accurate and insightful, it is intended for informational purposes only and should not be considered financial advice. Any content created by an AI (Artificial Intelligence) system may contain inaccuracies and/or contain errors. Investing in stocks carries inherent risks, and past performance is not indicative of future results. This report does not account for your personal financial circumstances, objectives, or risk tolerance. Always conduct your own research or consult with a qualified financial advisor before making investment decisions. The analysis and recommendations provided are based on historical and current data and may not fully reflect future market conditions or unexpected developments. Neither the creators of this report nor its affiliated entities guarantee the accuracy, completeness, or reliability of the information presented. Use this report at your own discretion and risk.

Date of analysis: Oct 21, 2026