Milestone Payment and Cash Position
Received a $25.0 million milestone from Chiesi following European Commission approval of Elfabrio every-4-weeks dosing; ended Q1 2026 with $51.0 million in cash, cash equivalents and short-term bank deposits, and no outstanding debt or warrants, providing substantial financial flexibility.
Reaffirmed 2026 Revenue Guidance
Reaffirmed full-year 2026 guidance of approximately $78 million to $83 million total revenue (inclusive of the $25 million milestone). Within that outlook, company expects Elfabrio revenues (excluding milestones) of ~$33 million to $35 million and Elelyso revenues of ~$20 million to $23 million.
Quarterly Profitability Driven by Milestone
Reported Q1 2026 net income of $18.3 million ($0.23 per share; $0.22 fully diluted) versus a net loss of $3.6 million ($0.05 per share) in Q1 2025 — a positive swing of $21.9 million year-over-year, largely attributable to the $25 million milestone.
Commercial Momentum for Elfabrio
European EC approval of Elfabrio every-4-weeks regimen is expected to reduce treatment burden and strengthen competitive position; company projects Elfabrio could capture 15%–20% of the global Fabry market (global Fabry market projected to approach ~$3.2 billion by 2031).
Progress on Clinical Pipeline — PRX-115
PRX-115 Phase II RELEASE study is actively enrolling with top-line results anticipated in the second half of 2027; company increased R&D investment to support study initiation and sees PRX-115 as a top clinical priority.
Lower Cost of Revenues Supporting Margins
Cost of revenues decreased to $4.1 million in Q1 2026 from $8.2 million in Q1 2025 (approximately a 50% reduction), reflecting lower volumes to certain partners and contributing to improved gross margin in the quarter.