OpRegen Program Progress
OpRegen, an allogeneic RPE cell transplant for dry AMD, shows promising results with anatomical and functional benefits lasting up to two years from one-time surgical delivery. The Phase 2a GAlette Study is progressing well, with Genentech continuing to invest in the program by acquiring RMAT designation and proprietary surgical delivery devices.
Manufacturing Milestone Achieved
Lineage achieved a GMP production run capable of producing millions of doses of product from a single starting cell line, demonstrating capability across multiple cell types and lines. This positions the company for new partnership opportunities.
OPC1 Program Advancements
A new delivery device for OPC1, designed to enhance safety and usability, is being tested. The device allows cell administration without stopping patient respiration, improving the procedure. Enrollment for the DOSED study is anticipated to begin in June.
Financial Stability
Lineage reported a cash position of $47.9 million as of March 31, 2025, expected to support operations into Q1 2027. The company also has approximately $37 million in warrant capital and is pursuing additional funding sources.