Promising Market Potential for Structure Therapeutics: Buy Rating Backed by Superior Trial Results and Market OpportunitiesIn addion to Lilly’s (NYSE: LLY) EASD presentaon on orfoglipron’s Phase 3 ATTAIN-1 data in obesity and concurrent publicaon in NEJM (note here), the company also released top-line results from ACHIEVE- 3, which was a Phase 3, open-label head-to-head trial comparing orforglipron to oral semaglude in type 2 diabecs (T2D) inadequately controlled on meormin (n=1,698). Consistent with prior observaons we flagged in our resumpon of coverage piece (link here, slide 21), which eluded to the parity or even superiority of orfoglipron vs other injectable increns in T2D, in ACHIEVE-3, orfoglipron significantly outperformed its approved oral pepde competor (Rybelsus [oral semaglude]) on lowering HbA1C and weight loss. Specifically, paents receiving 36mg orfoglipron experienced 2.2% reducons in HbA1C, versus a 1.4% reducon for 14mg oral semaglude (p<0.001).