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Dyne Therapeutics (DYN) AI Stock Analysis

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DYN

Dyne Therapeutics

(NASDAQ:DYN)

Select Model
Rating:50Neutral
Price Target:$18.50â–²(6.57% Upside)
Action:reiterated
Date:11/05/26

The score is held down primarily by weak financial performance (no revenue, widening losses, and rising cash burn), partially offset by a comparatively supportive balance sheet. Technicals are mixed with only modest near-term momentum. Valuation remains challenging due to ongoing losses, while the recent positive DM1 clinical data provides a meaningful but not decisive upside catalyst.

Positive Factors
Clinical validationSustained improvements across functional and patient-reported measures, together with a favorable safety profile, strengthen the clinical rationale for Dyne’s DM1 program. If upcoming registrational data confirm these findings, the evidence could support regulatory progress and improve the platform’s commercial potential.
Negative Factors
Pre-commercial economicsDyne has not established a product revenue base, while losses have widened from about $149M in 2021 to roughly $605M TTM. Until a program reaches commercialization, the business remains dependent on external funding and successful clinical execution to build operating leverage.

Dyne Therapeutics (DYN) vs. SPDR S&P 500 ETF (SPY)

-30%-20%-10%0%10%20%30%40%50%DYN-6.21%SPY+10.42%Dec '25Jan '26Feb '26Mar '26Apr '26May '26Jun '26Jul '26Aug '26Sep '26Oct '26Nov '26
Market Cap
$3.46B
Dividend Yield
―
Average Volume (3M)
2.81M
Price to Earnings (P/E)
-5.6
Beta (1Y)
1.61
Revenue Growth
―
EPS Growth
13.71%
Country
US
Employees
289
Sector
Healthcare
Sector Strength
51
Industry
Biotechnology

Dyne Therapeutics Business Overview & Revenue Model

Company Description

Dyne Therapeutics, Inc. is a U.S.-based biotechnology firm focused on developing advanced treatments for genetically driven muscle disorders. Utilizing its proprietary FORCE platform, which is engineered to deliver disease-modifying therapeutics, the...

How the Company Makes Money

Dyne Therapeutics primarily generates revenue from collaboration and partnership arrangements rather than product sales (given its clinical-stage status). These arrangements can include upfront payments, research funding and cost reimbursements, and...

Dyne Therapeutics Financial Statement Overview

Summary

Weak financial performance driven by no meaningful revenue, widening net losses (to roughly -$605M TTM), and accelerating cash burn (operating cash flow around -$565M TTM). The balance sheet provides some offset with sizable equity (~$931M TTM) and low leverage ratios, though debt has increased sharply in TTM (~$244M).

Income Statement

12Very Negative

Balance Sheet

62Positive

Cash Flow

18Very Negative
Financial statement breakdown
BreakdownTTMDec 2025Dec 2024Dec 2023Dec 2022Dec 2021
Income Statement
Total Revenue000000
Gross Profit-1.07M-2.05M-2.24M-2.46M00
EBITDA-577.74M-437.97M-315.75M-234.26M-163.50M-148.20M
Net Income-604.92M-446.21M-317.42M-235.94M-168.10M-149.29M
Balance Sheet
Total Assets1.23B1.19B691.23M165.08M306.32M425.66M
Cash, Cash Equivalents and Short-Term Investments1.13B1.11B642.27M123.10M256.01M376.57M
Total Debt244.28M20.28M23.99M27.41M30.48M32.64M
Total Liabilities303.87M214.83M61.40M73.79M53.96M57.47M
Stockholders Equity930.93M972.13M629.84M91.29M252.36M368.20M
Cash Flow
Free Cash Flow-568.76M-405.13M-294.75M-188.89M-156.71M-123.18M
Operating Cash Flow-564.53M-403.21M-292.37M-188.16M-153.65M-119.56M
Investing Cash Flow-7.50M-28.75M-204.08M83.31M87.20M-137.89M
Financing Cash Flow914.24M890.31M809.89M54.32M37.39M157.82M

Dyne Therapeutics Technical Analysis

Technical Analysis SentimentNegative
Last Price17.36

Price Trends

50DMA17.86Negative
100DMA20.94Negative
200DMA19.33Negative

Market Momentum

MACD0.08Negative
RSI52.75Neutral
STOCH78.97Neutral

Evaluating momentum and price trends is crucial in stock analysis to make informed investment decisions. For DYN, the sentiment is Negative. The current price of 17.36 is above the 20-day moving average (MA) of 16.30, below the 50-day MA of 17.86, and below the 200-day MA of 19.33, indicating a neutral trend. The MACD of 0.08 indicates Negative momentum. The RSI at 52.75 is Neutral, neither overbought nor oversold. The STOCH value of 78.97 is Neutral, not indicating any strong overbought or oversold conditions. Overall, these indicators collectively point to a Negative sentiment for DYN.

Dyne Therapeutics Risk Analysis

Dyne Therapeutics disclosed 83 risk factors in its most recent earnings report. Dyne Therapeutics reported the most risks in the "Tech & Innovation" category.

Higher RiskSector Avg.Lower RiskFinance & CorporateTech & InnovationLegal & RegulatoryProductionAbility to SellMacro & Political
Tech & Innovation - Risks related to the company’s reliance on technology and ability to make innovative products

Latest Risks Added

0 New Risks

Dyne Therapeutics Peers Comparison

Overall Rating

UnderperformOutperform
Sector (51)

Financial Indicators

DYN against its peers
NameOverall RatingMarket CapP/E RatioROEDividend YieldRevenue GrowthEPS Growth
SRPTSRPT58Neutral$1.96B-13.19-9.96%―-20.44%-349.84%
PTCTPTCT56Neutral$5.69B-52.6557.10%―-35.05%-113.73%
Sector *51Neutral$7.86B-0.30-43.30%2.27%22.53%-2.21%
DYNDYN50Neutral$3.37B-5.57-64.30%――13.71%
WVEWVE45Neutral$706.08M-3.38-44.48%―-35.07%-45.17%
EWTXEWTX44Neutral$4.09B4.06-39.01%――-18.88%
SLDBSLDB39Underperform$673.37M-4.56-72.28%――31.81%

* Healthcare Sector Average

Performance Comparison

-50%0%50%100%150%DYNSRPTPTCTWVESLDBEWTXDec '25Jan '26Feb '26Mar '26Apr '26May '26Jun '26Jul '26Aug '26Sep '26Oct '26Nov '26
DYN and its peers over the selected period
Show on chartTickerCompany NamePriceChange% Change
DYNDyne Therapeutics, Inc.17.36-1.00-5.45%
SRPTSarepta Therapeutics Inc.17.57-0.06-0.34%
PTCTPTC Therapeutics65.67-6.11-8.51%
WVEWave Life Sciences Pte. Ltd3.22-4.64-59.03%
SLDBSolid Biosciences6.182.1252.22%
EWTXEdgewise Therapeutics, Inc.38.8721.71126.52%

Dyne Therapeutics Corporate Events

Business Operations and StrategyProduct-Related Announcements

Dyne Therapeutics Highlights New ACHIEVE DM1 Trial Data

Positive
Sep 29, 2026

On September 29, 2026, Dyne Therapeutics reported additional one-year clinical data from the multiple ascending dose portion of its Phase 1/2 ACHIEVE trial of zeleciment basivarsen for myotonic dystrophy type 1, showing sustained functional, strength...

Glossary
BuyA stock rated as a "Buy" is expected to perform better than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock is likely to deliver higher returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
HoldA stock rated as a "Hold" is expected to perform in line with the overall market or a specific benchmark. This rating indicates that the stock is neither particularly compelling nor unfavorable for investment. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
SellA stock rated as a "Sell" is expected to perform worse than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock may deliver lower returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.

Disclaimer

This AI Analyst Stock Report is automatically generated by our AI systems using advanced algorithms and publicly available financial, technical, and market data. While the information provided aims to be accurate and insightful, it is intended for informational purposes only and should not be considered financial advice. Any content created by an AI (Artificial Intelligence) system may contain inaccuracies and/or contain errors. Investing in stocks carries inherent risks, and past performance is not indicative of future results. This report does not account for your personal financial circumstances, objectives, or risk tolerance. Always conduct your own research or consult with a qualified financial advisor before making investment decisions. The analysis and recommendations provided are based on historical and current data and may not fully reflect future market conditions or unexpected developments. Neither the creators of this report nor its affiliated entities guarantee the accuracy, completeness, or reliability of the information presented. Use this report at your own discretion and risk.

Date of analysis: Nov 05, 2026