Vigil says interim IGNITE Phase 2 data demonstrate VGL101 potential for ALSP

Vigil Neuroscience announced the presentation of multiple oral and poster presentations on the company’s lead clinical candidate iluzanebart at the 2024 American Academy of Neurology AAN Annual Meeting. “We are excited to see our enthusiasm for iluzanebart matched by clinical leaders in the ALSP community. The interim findings from both the IGNITE Phase 2 and ILLUMINATE Natural History studies support the potential of iluzanebart to become the first, disease-modifying therapy for those living with ALSP,” said Petra Kaufmann, M.D., F.A.A.N, Chief Medical Officer of Vigil. “Both trials have led to an incredible step forward – not only in understanding ALSP disease progression, but also in drawing parallels between biomarkers and correlating clinical outcomes. “Vigil’s interim IGNITE data demonstrated that iluzanebart was well-tolerated, and the data suggest a favorable impact on the protein product of the CSF1R gene whose dysfunction is the causal driver of ALSP,” said Zbigniew Wszolek, M.D., consultant in the Department of Neurology at the Mayo Clinic. “Positive trends on MRI measurements support slowing in irreversible neurodegeneration, and to see these signals in patients as early as six months is very encouraging.”…”The findings from ILLUMINATE highlight sensitive markers of ALSP pathophysiology that have the potential to provide valuable insight into clinical endpoints and improve the overall understanding of ALSP disease progression to inform future study designs,” said David Lynch, Ph.D., Honorary Research Fellow, Department of Neuromuscular Diseases, University College London.