Transcode remains ‘steadfast’ on advancing pipeline, exploring collaborations

In a letter to shareholders, Transcode CEO R. Michael Dudley said, “I want to express the optimism that permeates the management, board, and staff of TransCode as we navigate the ever-evolving oncology field and venture into the clinic with our lead candidate to treat metastatic disease. This optimism is also reflected by the fact that members of management have purchased shares of the Company in the open market in the past two weeks. I am delighted to inform you about the accomplishments and advancements we have attained at TransCode following our initial public offering in July 2021. Your unwavering support and trust in our mission have been of immeasurable value, and I am grateful for your steadfast dedication. In our dedicated pursuit to transform the treatment of cancer, we believe TransCode Therapeutics has made significant strides in research, innovation, and clinical development. Our team of scientists, researchers, and professionals have tirelessly worked towards this pursuit, and I am delighted to report that we have achieved several noteworthy milestones. One of our achievements this year has been the successful advancement of our lead therapeutic candidate, TTX-MC138, utilizing our proprietary targeted therapeutic delivery platform. TTX-MC138 is focused on treating metastatic cancer, as characterized by the spread of a tumor from the organ of origin to other parts of the body, which is believed to be the cause of approximately 90% of all cancer deaths totaling over nine million per year worldwide. We believe that TTX-MC138 has the potential to produce regression without recurrence in a range of metastatic cancers, including breast, pancreatic, ovarian and colon cancer, glioblastomas and many others. We have observed significant tumor regression and durable responses in multiple animal models, which we believe support the therapeutic potential of TTX-MC138. In December 2022, we received approval from the FDA to proceed with our first-in-human clinical trial. In April 2023, we received institutional review board approval from Dana Farber Cancer Center in Boston, MA, to enroll and dose patients in our Phase 0 trial, which we expect to commence shortly. In parallel, we are completing IND enabling studies for our planned Phase I/II clinical trial, for which we hope to file an IND application with FDA later this year to initiate our clinical trial to treat cancer patients…As we look ahead, we remain steadfast in our commitment to advancing our pipeline, expanding collaborations, and exploring new therapeutic avenues. Our goal is to continue pushing the boundaries of what is possible in the field of oncology, bringing hope to patients and transforming the treatment landscape. We are hopeful that our targeted therapeutic delivery platform, exemplified by the progress of TTX-MC138, will play a pivotal role in realizing this vision.”