Tonix Pharmaceuticals announces presentations of pre-clinical data on TNX-1700

Tonix Pharmaceuticals announced the presentation of two posters with research results on TNX-1700 at the American Association for Cancer Research, AACR, Annual Meeting, held April 14-19, 2023, in Orlando, Fla. The poster presentation, titled, "MDSC-targeted TFF2-MSA suppresses tumor growth and increases survival in anti-PD-1 treated MC38 and CT26.wt murine colorectal cancer models," includes data demonstrating that targeting myeloid-derived suppressor cells using murine TNX-1700, or mTNX-1700 synergizes with PD-1 blockade therapy in advanced syngeneic mouse models of colorectal cancer. The data show that mTNX-1700 and anti-PD-1 monotherapy each were able to evoke anti-tumor immunity in the MC38 and CT26.wt models of colorectal cancer, and that mTNX-1700 augmented the anti-tumor efficacy of anti-PD-1 therapy in both of these colorectal cancer models. The poster presentation, titled, "MDSC-targeted TFF2-MSA synergizes with PD-1 blockade therapy in diffuse-type gastric cancer," includes data showing that targeting MDSCs using mTNX-1700 synergizes with PD-1 blockade therapy in advanced and metastatic syngeneic mouse models of diffuse-type gastric cancer, suggesting combination therapy of mTNX-1700 and PD-1 blockade may also be applicable to gastric cancer.