Tonix Pharmaceuticals (TNXP) announced a collaboration with Massachusetts General Hospital, MGH, a founding member of Mass General Brigham, MGB, to conduct a Phase 2 clinical trial evaluating monoclonal antibody TNX-1500 in kidney transplant recipients. The investigator-initiated study will be led by Ayman Al Jurdi, M.D., at MGH and is designed to assess the safety, tolerability and activity of Fc-modified anti-CD40L mAb TNX-1500 in preventing kidney transplant rejection while significantly minimizing the dose of conventional immunosuppressive drugs, which are associated with infection, cancer, cardiovascular side effects and various metabolic derangements. The CD40 ligand is also known as CD154. Study initiation is contingent on institutional review board approval and FDA clearance of an investigator-initiated investigational new drug application, IND.
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