Synlogic reports publication of prelinical, clinical data for SYNB1353

Synlogic announced the publication of a manuscript detailing the development and activity of SYNB1353 in preclinical models and demonstrating safety, tolerability, and clinical proof of mechanism in healthy volunteers through the successful lowering of methionine, a precursor to homocysteine, in a dietary model of classical homocystinuria. Among findings outlined in the manuscript, SYNB1353 efficiently degraded both dietary and entero-recirculating methionine to prevent its absorption and subsequent conversion to homocysteine in preclinical models, suggesting that SYNB1353 should result in lowering of plasma homocysteine levels in HCU patients. In addition, in results from the clinical study in healthy volunteers, SYNB1353 was generally well-tolerated and adverse events were mild to moderate, transient, and predominantly gastrointestinal in nature. The proportion of subjects reporting gastrointestinal events were similar for the SYNB1353 and placebo cohorts. “Given the significant disease burden and acute need for new treatment options for those affected by classical HCU, we are pleased to share these findings that highlight the potential of our novel approach, which targets methionine, an amino acid that has long been validated as a therapeutic target in classical HCU through the use of dietary restrictions,” said Mylene Perreault, Ph.D., Head of Research at Synlogic. “Importantly, the SYNB1353 program has built on learnings and progress from our other rare metabolic disease programs, including the design of the potential therapeutic, the preclinical research and the advancement in clinical development.”