Oncternal announces first patient dosed in fourth cohort of study of ONCT-534

Oncternal Therapeutics announced that the first patient has been dosed in the fourth cohort of its Phase 1/2 study of ONCT-534 for the treatment of patients with advanced prostate cancer who are relapsed or refractory to approved androgen receptor pathway inhibitors. Patients in the fourth dosing cohort will receive ONCT-534, the company’s dual-action androgen receptor inhibitor, at a dose of 300 mg taken orally each day. “Reaching the 300 mg dose level represents a significant milestone for our ONCT-534 program. The drug has been well tolerated so far, and based on preclinical analyses, we are optimistic that study participants are receiving doses of ONCT-534 that may be within the active dose range for antitumor activity,” said Salim Yazji M.D., Chief Medical Officer at Oncternal Therapeutics. “We continue to see strong demand from investigators and patients to participate in the study and expect to continue enrolling at a brisk pace. We look forward to announcing initial efficacy and safety data from the study, which we expect will be at the end of this quarter.”