Neurocrine to present data on Ingrezza capsule dissolution performance

Neurocrine will present data from three in vitro dissolution studies exploring the dissolution performance of Ingrezza capsule contents through soft foods or a gastrostomy feeding tube. The data will be presented at AMDA – The Society for Post-Acute and Long-Term Care Medicine’s PALTC23 Annual Conference held March 9-12 in Tampa, Florida. The in vitro data demonstrated that crushing Ingrezza capsule contents did not impact dissolution performance when compared to whole capsules. Further, mixing the contents with soft foods or liquids of a broad pH range or delivering the contents dissolved in tap water via G-tube resulted in acceptable dissolution performance of Ingrezza. This information may be important for patients with tardive dyskinesia, especially those who are elderly, who may have trouble swallowing capsules because of their abnormal movements or other comorbid conditions. Three studies were conducted to explore the potential of adding crushed Ingrezza capsule contents to soft foods or a gastrostomy feeding tube. In Study 1, Ingrezza capsules could be opened manually, with the contents crushed between spoons. Very rapid and complete drug release was observed in all samples. In Study 2, recovery of crushed Ingrezza capsule contents was acceptable within 2 hours of adding them to the tested foods and buffers/fed state simulated gastric fluid. Study 3 showed acceptable Ingrezza recovery following G-tube administration when crushed capsule contents were dissolved in hot or cold water and a cup rinse was performed.