Lexaria says DehydraTECH-CBD achieves superior human blood absorption levels

Lexaria Bioscience announce it has demonstrated superior cannabidiol blood absorption levels from its patented DehydraTECH-CBD relative to those of published, pharmaceutical-grade CBD industry comparators in its recently completed, multi-week human clinical hypertension study HYPER-H21-4. In a 2017 randomized clinical trial that evaluated a non-Lexaria, pharmaceutical-grade, plant-derived CBD formulation published by Devinski et. al., an average blood plasma CBD level of 23.0 ng/mL was evidenced after 22 days of daily dosing at a 5 mg/kg CBD dose level. By comparison, in Lexaria’s 2022 HYPER-H21-4 hypertension study, a 45.8% higher average blood plasma level was reached at DehydraTECH-CBD’s lowest dose level tested of just 3.38 mg/kg, climbing to a blood plasma level that was 133.4% higher at its highest dose level tested of 4.46 mg/kg. The Devinsky publication also examined higher CBD dosing at a level of 10 mg/kg, evidencing a blood level of 62.1 ng/mL. Although Lexaria’s HYPER-H12-4 study did not see the need to dose as high as 10 mg/kg, the data trend observed at its 3.38 and 4.46 mg/kg dose levels extrapolated linearly to 10 mg/kg would be expected to reach a level of 149.5 ng/mL; a 141% improvement over the Devinsky CBD formulation. Similarly, a 2019 study published by Wheless et. al., also evaluated average CBD levels in blood following dosing to steady-state1 over a multi-day period, using a different pharmaceutical-grade, synthetic CBD formulation. At a 10 mg/kg dose level in the Wheless study, the non-Lexaria synthetic CBD reached a level within blood plasma of 91 ng/mL.; DehydraTECH-CBD absorption outperformed this synthetic CBD by 64% improvement upon linear extrapolation. Additional study endpoint analyses as described in the complete study protocol are still underway and any relevant material findings will be reported upon in due course as these findings become available. It is highly likely that multiple additional datasets will be released in January through March of 2023. Lexaria’s HYPER-H21-4 study was a randomized, double-blinded, placebo-controlled, cross-over study of a total of 66 male and female volunteers between the ages of 40-70. All study participants received DehydraTECH-CBD every day for a total of 5 weeks. Blood CBD levels reported herein from DehydraTECH-CBD administration were measured prior to dosing, as was the case reported in the Devinsky article, whereas the Wheless article did not specify blood sampling timing relative to dosing. The complete HYPER-H21-4 study protocol has been published and is available at PubMed.