Kymera Therapeutics provides 2024 corporate goals

Kymera’s corporate goals for 2024 include: Immunology Portfolio: Kymera is working to build an industry-leading oral immunology pipeline by leveraging its disease agnostic discovery platform, deep expertise gained through the development of its first-in-class IRAK4 program, and unique target selection strategy that focuses on genetically and clinically validated pathways, to build a portfolio of oral medicines with efficacy comparable to in-pathway biologics. Collaborate with Sanofi to complete enrollment of the KT-474/SAR444656 Phase 2 hidradenitis suppurativa and atopic dermatitis clinical trials, with topline data expected to be reported in the first half of 2025. KT-474 is an oral IRAK4 degrader, in development for the treatment of IL-1R/TLR-driven complex inflammatory diseases. Sanofi, which is collaborating with Kymera on the development of KT-474 outside of the oncology and immune-oncology fields, is conducting the Phase 2 studies. Kymera has an option after Phase 2 and prior to the first Phase 3 study to opt in and equally share development and commercialization costs and profits in the U.S. while retaining tiered royalties in the rest of the world. Initiate dosing in the KT-621 Phase 1 trial in the second half of 2024, with Phase 1 data expected to be reported in 2025 KT-621 has shown in preclinical studies to be a potent, oral degrader of STAT6, the only specific transcription factor responsible for IL-4/IL-13 signaling and the central driver of Type 2 inflammation in allergic diseases, with in vitro and in vivo efficacy similar or superior to dupilumab. KT-621 has potentially broad utility across a number of allergic diseases, including atopic dermatitis, asthma and chronic obstructive pulmonary disorder, among others. Complete activities to enable IND filing and initiate dosing in the KT-294 Phase 1 clinical trial in the first half of 2025, with Phase 1 data expected to be reported in 2025. KT-294 has shown in preclinical studies to be a potent oral degrader of TYK2, a member of the Janus Kinase family required for Type I interferon, IL-12 and IL-23 signaling with both genetic and clinical validation in autoimmune and inflammatory diseases. Degradation of TYK2 has the potential to overcome the challenges of small molecule inhibitors, which have limitations due to lack of selectivity, limited target engagement, and/or lack of potent activity. KT-294, with a potential biologic-like efficacy profile, has the opportunity to address conditions such as inflammatory bowel disease, psoriasis, psoriatic arthritis and lupus, among others. Oncology Portfolio: Kymera is progressing degrader programs in oncology that target undrugged or poorly drugged proteins in an effort to create new ways to fight cancer that improve the standard of care and have the potential treat both solid and liquid tumors. Complete the KT-333 Phase 1a study and deliver additional proof-of-concept data to inform the program’s next development steps in 2024: KT-333 is designed as a potent degrader of STAT3, a transcriptional regulator that has been linked to numerous cancers as well as to inflammatory and autoimmune diseases. KT-333 is being developed for the treatment of STAT3-dependent hematological malignancies and solid tumors. At the American Society of Hematology annual meeting, the Company disclosed the first proof-of-concept data for single agent KT-333 anti-tumor activity in hematological malignancies as well as potential anti-tumor immuno-modulatory effects in both tumor biopsies and blood. Complete the KT-253 Phase 1a study and deliver proof-of-concept data, which will inform a patient stratification strategy for the program in 2024: KT-253 is a highly potent and selective degrader that targets MDM2, the crucial regulator of the most common tumor suppressor, p53. A Phase 1 study of KT-253 is ongoing, with one arm in patients with relapsed or refractory solid tumors and lymphomas, and a second arm focused on patients with high grade myeloid malignancies and acute lymphocytic leukemia. Interim data from the study demonstrated evidence of target engagement and p53 pathway activation, as well as initial antitumor activity and a lack of the traditional hematological toxicity seen with small molecule inhibitors. Kymera is working to develop a biomarker-based patient selection strategy for subsequent development beyond Phase 1a. Research and Platform: Continue to advance, from early discovery through preclinical development, a series of high value programs in areas of unmet need with large patient populations and target classes best suited for TPD