Imunon announces article on IMNN-101 preclinical data

IMUNON announces that an article titled “Strong immunogenicity & protection in mice with PlaCCine: A COVID-19 DNA vaccine formulated with a functional polymer” by Subeena Sood, Majed M. Matar, et. Al. The study described in the article used IMUNON’s proprietary formulation against the spike proteins from two SARS-CoV-2 variants, both alone and in combination. Data from the study show: IMUNON’s proprietary formulation of functionalized polymer protected DNA from degradation, while the combination with an adjuvant led to an increase in protein expression. DNA formulated with PlaCCine resulted in a DNA vaccine product that was stable for up to one year at 4 degrees C. DNA formulated in PlaCCine resulted in the induction of spike-specific neutralizing antibodies and cytotoxic T cells. In the in vivo challenge model, the vaccine-induced immune response was capable of suppressing viral replication. Multiple inserts can be cloned into the PlaCCine backbone , therefore allowing for an immune response with broader protection.