Immutep granted U.S. patent for IMP761

Immutep announced the grant of a new patent by the United States Patent Office. The granted claims are composition-of-matter type claims covering Immutep’s pre-clinical immunosuppressive product candidate IMP761, a first-in-class agonist LAG-3 antibody designed to target the root cause of autoimmune diseases by directly silencing self-antigen-specific effector T cells. The patent is owned by Immutep S.A.S. and will expire on 22 February 2037. This new United States patent follows the grant of the equivalent Japanese and European patents announced in July 2022 and October 2020, respectively. A divisional application has also been filed to pursue claims drawn to methods of treating T-cell mediated immune disorders, such as inflammatory or autoimmune diseases, by administration of IMP761. Immutep CSO, Dr. Frederic Triebel, said: “We have been making good progress in advancing IMP761 towards potential first-in-human clinical testing. In particular, we developed a 200L GMP-compliant manufacturing process in collaboration with our colleagues at Northway Biotech late last year, and more recently selected Charles River Laboratories to conduct a GLP toxicology study, a key step prior to first-in-human trials. In tandem, we continue to build our patent estate around this first-in-class drug candidate in key markets globally.”