Horizon updates Uplizna data from analyses of the N-MOmentum trial for NMOSD

Horizon Therapeutics announced new data from two post-hoc analyses of the N-MOmentum clinical trial of UPLIZNA for the treatment of neuromyelitis optica spectrum disorder will be presented at the eighth annual Americas Committee for Treatment and Research in Multiple Sclerosis Forum, February 23-25, 2023, in San Diego. These data suggest UPLIZNA does not increase susceptibility to COVID infection or deplete childhood vaccine-generated antibodies. UPLIZNA is the first and only B-cell-depleting monotherapy approved by the U.S. Food and Drug Administration and the European Commission for the treatment of NMOSD in adults who are anti-aquaporin-4 immunoglobulin G seropositive . "UPLIZNA prevents NMOSD attacks by targeting CD19-expressing B cells that are a key driver of NMOSD activity," said Bruce Cree, M.D., Ph.D., MAS, study author and professor of Clinical Neurology at the University of California San Francisco Weill Institute for Neurosciences. "Through ongoing studies and clinical use, we are learning that UPLIZNA’s impact on NMOSD activity is very focused and may not interfere with certain other immune responses. Patients treated with UPLIZNA appear to not be more susceptibile to COVID-19 infections or to develop waning immunity from prior vaccinations due to treatment."