Gritstone publishes interim results from Phase 1/2 study of SLATE

Gritstone bio announced that a paper detailing the development of its “off-the-shelf” neoantigen platform, SLATE, recently published in Nature Medicine. The paper, “A shared neoantigen vaccine combined with immune checkpoint blockade for advanced metastatic solid tumors: phase 1 trial interim results,” describes a novel immunodominance hierarchy of tumor neoantigens that Gritstone discovered in Phase 1 translational studies and leveraged to develop SLATE-KRAS. “The publication of these findings in Nature Medicine highlights the promise of our ‘off-the-shelf’ or shared neoantigen approach in solid tumors, one of the many elements embedded within our mission to develop the world’s most potent vaccines,” said Andrew Allen, M.D., Ph.D., Co-founder, President, and Chief Executive Officer of Gritstone bio. “Our team’s innovative work to develop, optimize and validate SLATE positions Gritstone with two promising platforms to execute against our neoantigen-directed approach to oncology. It also enabled the pioneering collaboration that we are currently advancing with Dr. Rosenberg of the NCI, a luminary in the field. SLATE is ready for ‘plug and play’ application across a spectrum of solid tumors and could serve as a great complementary platform to GRANITE, our personalized vaccine program. We continue to have great conviction that both approaches could unlock new levels of immune responses for patients with solid tumors.”