Clearside Biomedical reports progress in ODYSSEY Phase 2b trial of CLS-AX

Clearside Biomedical announced today that it has completed randomization in its ODYSSEY Phase 2b clinical trial of CLS-AX in neovascular age-related macular degeneration. Topline data results are expected in the third quarter of 2024. “As we continue to make significant progress in our ODYSSEY trial, we are optimistic about the potential benefits of CLS-AX, our proprietary suspension of axitinib for suprachoroidal injection,” said George Lasezkay, Pharm.D., J.D., President and Chief Executive Officer. “Axitinib is a highly-potent tyrosine kinase inhibitor that achieves pan-VEGF blockade, directly inhibiting VEGF receptors-1, -2, and -3 with high potency and specificity. We believe TKIs have the potential to play a significant role in the treatment of wet AMD. In ODYSSEY, we are looking to replicate the excellent safety profile, stable vision, and reduced frequency of injections we observed in our OASIS Phase 1/2a trial and its 3-month Extension Study. The differentiated mechanism of action and high potency of axitinib combined with delivery into the suprachoroidal space with our proprietary SCS Microinjector has the potential to be a best-in-class approach for long-term maintenance therapy for wet AMD patients,” concluded Dr. Lasezkay.