Chemomab Therapeutics presents new data on CM-101, CCL24

Chemomab Therapeutics reported on its oral and poster presentations at AASLD’s The Liver Meeting 2023, being held November 10-14, 2023. In an oral presentation by Ilan Vaknin, PhD, Chemomab’s Vice President of R&D, analysis of serum samples from patients with primary sclerosing cholangitis provided further evidence that the soluble protein CCL24 is associated with key inflammatory and fibrotic pathways implicated in the liver damage characterizing PSC.1 Chemomab’s first-in-class monoclonal antibody CM-101 is designed to neutralize CCL24 and normalize PSC’s fibro-inflammatory disease processes. CM-101 is currently in a Phase 2 trial in PSC patients that is advancing towards completion of enrollment. A top-line data readout is expected in the second half of next year. There currently are no FDA-approved therapies for this devastating, often lethal disease. A poster presentation hosted by Matt Frankel, MD, Chief Medical Officer of Chemomab, described key findings from proteomic analyses of serum samples at baseline and after 16 weeks of treatment with CM-101 from the company’s Phase 2a liver fibrosis trial in patients with nonalcoholic steatohepatitis. These analyses demonstrated consistent and significant reductions in liver-related pathology pathways that lead to liver damage, activation of liver fibroblasts and liver steatosis. Moreover, proteomic analysis showed that CM-101 treatment led to significant downregulation in multiple immune-related pathways, along with an increase in metabolic pathways associated with improved glucose and fat metabolism. The study also indicated that CM-101 has a strong and specific target engagement profile for CCL24.