Century Therapeutics: Data from iPSC-derived cell therapy presented at AACR

Century Therapeutics announced that preclinical data from the company’s iPSC-derived cell therapy platform was presented at the AACR Annual Meeting 2024. The posters highlight the Company’s end-to-end capabilities in iPSC reprogramming and differentiation, gene editing, synthetic biology, protein engineering and computational biology. “Together, the promising preclinical data showcase Century’s continued dedication to driving the field of allogeneic cell therapy through the incorporation of a suite of innovations into next generation product candidates,” said Hy Levitsky, M.D., President of Research and Development at Century Therapeutics. “We presented new data advancing our Allo-Evasion platform through the transgenic expression of HLA-G, which along with HLA-E can augment the protection against host natural killer cell-mediated rejection of iPSC derived cells also engineered to resist T cell recognition through the elimination of HLA-I and HLA-II expression. This enhanced protection against rejection is designed to enable Century’s multi-dosing strategy that increases the period of drug exposure, potentially leading to deeper and more durable responses for patients in need. We also presented new data describing our novel, dual-targeting CAR for B cell mediated malignancies which demonstrated promising in vitro and in vivo cytotoxicity and resisting antigen loss, and which we believe expands the potential of allogeneic CAR-T cell therapy beyond currently available options in oncology that only target CD19. Along with other important preclinical data presented at AACR, the findings to date highlight our unique gene editing, protein engineering, and manufacturing capabilities that are the foundations of our industry-leading allogeneic cell therapy pipeline and platform.”