Biogen to highlight progress in rare kidney disease at ASN Kidney Week

Biogen (BIIB) will present new data from its felzartamab clinical development programs at Kidney Week 2025, the American Society of Nephrology’s annual meeting, taking place November 5-9 in Houston, Texas. Felzartamab, an investigational anti-CD38 monoclonal antibody, is currently being evaluated in three pivotal Phase 3 studies across multiple kidney indications. The first data readout is anticipated in 2027 from TRANSCEND, a study evaluating felzartamab in adult kidney recipients diagnosed with late antibody-mediated rejection. “Following the initiation of three pivotal Phase 3 studies in 2025, Kidney Week is a pivotal moment to showcase the potential promise of our anti-CD38 platform to address a range of rare kidney diseases,” said Uptal Patel, Head of Biogen West Coast Hub. “We’re presenting first-of-its kind gene expression data and evidence of preserved humoral immunity in patients with IgA nephropathy receiving felzartamab, findings that we believe will advance the understanding of this disease and offer meaningful insights to the nephrology community.” Biogen presentations include an oral presentation highlighting new translational RNAseq data from the Phase 2 IGNAZ study on felzartamab treated patients with IgA nephropathy. This longitudinal genomic profiling dataset links gene expression changes to felzartamab’s mechanism of action in IgAN. A poster presentation evaluates the impact of felzartamab on vaccine immunity in patients with IgAN, indicating that patients with IgAN receiving felzartamab demonstrated preservation of humoral immunity, which may contribute to a favorable safety profile versus other B-cell targeting therapies. In addition, a sponsored Exhibitor Spotlight will educate on the evolving sciences that illustrates a key role for CD38+ cells in immune-mediated kidney diseases, including AMR, IgAN, and primary membranous nephropathy. Attendees can also explore poster informational presentations on the three ongoing Phase 3 trials of felzartamab.