Mizuho downgraded Acadia Pharmaceuticals to Neutral from Buy with a price target of $25, down from $39. Given the failed ADVANCE-2 trial, the firm removed sales forecast for Nuplazid in negative symptoms of schizophrenia. The analyst now sees no near-term major catalysts in 2024 for the shares. The next major catalyst for Acadia could be in late 2025 or early 2026, the analyst tells investors in a research note.
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