Biontech Se Sponsored Adr ((BNTX)), Biontech SE (($CC:BNTX.CUR)) announced an update on their ongoing clinical study.
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BioNTech SE is currently sponsoring a clinical study titled ‘A Phase Ib/II, Multi-site, Open-label, Two-part Trial to Evaluate the Efficacy, Safety, Pharmacokinetics, and Recommended Combination Dose of BNT324 With BNT327 in Participants With Advanced Lung Cancer.’ The study aims to explore the efficacy and safety of a combination therapy involving BNT324, a B7-H3 antibody-drug conjugate, and BNT327, a PD-L1 and VEGF bispecific antibody, in patients with advanced lung cancer. This study is significant as it targets both small cell lung cancer (SCLC) and non-small cell lung cancer (NSCLC), potentially offering new treatment avenues for these challenging conditions.
The interventions being tested are BNT324 and BNT327, both administered via intravenous infusion. BNT324 is designed to target B7-H3, while BNT327 targets PD-L1 and VEGF, aiming to enhance the immune response against cancer cells and inhibit tumor growth.
The study is interventional, randomized, and follows a parallel assignment model with no masking. Its primary purpose is treatment-focused, aiming to establish safe and effective dose levels for the combination therapy in different lung cancer cohorts.
The study began on May 2, 2025, with its primary completion and estimated completion dates yet to be announced. The last update was submitted on August 11, 2025. These dates are crucial as they provide a timeline for when results might be expected, which can influence investor decisions.
The market implications of this study are significant for BioNTech SE, as successful outcomes could enhance its stock performance and investor confidence. The study’s progress and results could also impact the competitive landscape, particularly among companies developing similar therapies for lung cancer.
The study is ongoing, with further details available on the ClinicalTrials portal.