AstraZeneca ((AZN)) announced an update on their ongoing clinical study.
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AstraZeneca is currently conducting a Phase III clinical study titled ‘A Phase III, Randomised, Open-label, Sponsor-blinded, Multicentre Study of Rilvegostomig in Combination With Bevacizumab With or Without Tremelimumab as First-line Treatment in Patients With Advanced Hepatocellular Carcinoma.’ The study aims to evaluate the efficacy and safety of the drug rilvegostomig, in combination with bevacizumab, with or without tremelimumab, compared to the combination of atezolizumab and bevacizumab in patients with advanced hepatocellular carcinoma (HCC) who are not candidates for curative or locoregional therapy.
The interventions being tested include the drugs rilvegostomig, bevacizumab, and tremelimumab, all administered via intravenous therapy. These drugs are designed to treat advanced HCC by potentially improving patient outcomes compared to existing treatment options.
The study follows a randomized, parallel assignment model with a single masking approach, where the outcomes assessor is blinded. The primary purpose of the study is treatment-focused, aiming to determine the most effective first-line therapy for advanced HCC.
The study began on March 26, 2025, with primary completion and estimated completion dates yet to be announced. The latest update was submitted on August 28, 2025, indicating ongoing recruitment and progress.
This study update could influence AstraZeneca’s stock performance positively if results show significant efficacy, potentially boosting investor confidence. The study’s outcomes could also impact the competitive landscape in the HCC treatment market, affecting other companies with similar drug offerings.
The study is ongoing, and further details are available on the ClinicalTrials portal.