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Verastem (VSTM) Drug Pipeline

Drug pipeline
Drug NameConditionStageStatusStudy NameTrial Start DateArticle
Cetuximab, Vs-7375, Panitumumab, Cetuximab + Mfolfox6Colorectal CancerPhase IIRecruitingA Phase 2 Study of VS-7375 in Patients With KRAS G12D-Mutated Colorectal CancerJun 15, 2026
Vs-7375Non-small Cell Lung CancerPhase IIRecruitingA Phase 2 Study of VS-7375 in Patients With KRAS G12D-Mutated Non-Small Cell Lung CancerJun 15, 2026―
Cetuximab, Vs-7375G12d Mutated Kras, Pancreatic Ductal Adenocarcinoma (Pdac)Phase IIRecruitingA Phase 2 Study of VS-7375 in Patients With KRAS G12D-Mutated Pancreatic CancerMay 26, 2026
Cetuximab, Vs-7375G12d Mutated Kras, Colorectal Cancer, Non Small Cell Lung Cancer, Pancreatic Ductal Adenocarcinoma, Solid Tumor, Adultphase1AndPhase2RecruitingA Phase 1/2 Study of VS-7375 in Patients With KRAS G12D-Mutated Solid TumorsMay 26, 2025―
Avutometinib + DefactinibOvarian Cancer, Low Grade Serous Ovarian CancerPhase IIActive Not RecruitingA Study of Avutometinib + Defactinib in Recurrent Low-Grade Serous Ovarian Cancer in Japanese PatientsNov 05, 2024―
Paclitaxel, Avutometinib, Defactinib, Pegylated Liposomal Doxorubicin, Letrozole, AnastrozoleLow Grade Serous Ovarian CancerPhase IIIRecruitingA Study of Avutometinib (VS-6766) + Defactinib (VS-6063) in Recurrent Low-Grade Serous Ovarian CancerOct 02, 2023
Avutometinib And Defactinib In Combination With Gemcitabine And Nab-PaclitaxelPancreas Cancer, Kras Activating Mutation, Metastatic Cancer, Neoplasms Pancreatic, Malignant Neoplasm Of Pancreasphase1AndPhase2Active Not RecruitingStudy of Avutometinib (VS-6766) +Defactinib With Gemcitabine and Nab-paclitaxel in Patients With Pancreatic CancerDec 06, 2022―
Avutometinib And AdagrasibKras Activating Mutation, Malignant Neoplastic Disease, Malignant Neoplasm Of Lung, Metastatic Cancer, Advanced Cancer, Non Small Cell Lung Cancerphase1AndPhase2CompletedStudy of Avutometinib (VS-6766) + Adagrasib in KRAS G12C NSCLC PatientsMay 02, 2022
Vs-6766Food EffectPhase ICompletedFood Effect of VS-6766 in Healthy Adult SubjectsDec 23, 2021―
Avutometinib And Sotorasib, Avutometinib And Sotorasib And DefactinibKras Activating Mutation, Non Small Cell Lung Cancerphase1AndPhase2RecruitingPhase 1/2 Study of Avutometinib (VS-6766) + Sotorasib With or Without Defactinib in KRAS G12C NSCLC PatientsSep 29, 2021―

FAQ

What are the FDA phases for drug approval?
The FDA approval process for new drugs is divided into several phases: a. Preclinical testing b. Phase 1 – Safety and dosage c. Phase 2 – Effectiveness and side effects d. Phase 3 – Confirmation of effectiveness, monitoring of adverse reactions, and comparison with existing treatments e. Phase 4 – Post-marketing studies to track long-term safety and effectiveness
What is a clinical trial?
A clinical trial is a carefully designed study in which researchers test a drug, treatment, or medical device in people to evaluate its safety, effectiveness, and potential side effects. These trials are essential for determining whether a new treatment should be approved for widespread use.
What drugs does Verastem Inc (VSTM) have in its pipeline
Verastem VSTM is currently developing the following drugs: Cetuximab, Vs-7375, Panitumumab, Cetuximab + Mfolfox6, Vs-7375, Cetuximab, Vs-7375, Avutometinib + Defactinib, Paclitaxel, Avutometinib, Defactinib, Pegylated Liposomal Doxorubicin, Letrozole, Anastrozole, Avutometinib And Defactinib In Combination With Gemcitabine And Nab-Paclitaxel, Avutometinib And Adagrasib, Vs-6766, Avutometinib And Sotorasib, Avutometinib And Sotorasib And Defactinib, Avutometinib, Avutometinib And Defactinib, Part A - Vs-6063, Part A - Avelumab, Defactinib, Part B, Cohort 1- Vs-4718, Nab-Paclitaxel, Gemcitabine, Part B, Cohort 2- Vs4718, Nab-Paclitaxel, Gemcitabine, Part A- Vs-4718, Nab-Paclitaxel, Gemcitabine, Vs-5584 And Vs-6063, Vs-4718, Vs-6063, Vs-5584, Paclitaxel, Defactinib, Pf-04554878. These drug candidates are in various stages of clinical development as the company works toward FDA approval.