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Helix BioPharma (HBP) AI Stock Analysis

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TSE:HBP

Helix BioPharma

(TSX:HBP)

Select Model
Rating:38Underperform
Price Target:CAD 0.88â–²(4.00% Upside)
Action:reiterated
Date:11/12/26

The score is driven primarily by very weak financial performance, including zero revenue and ongoing cash burn. Negative valuation metrics and weak technical momentum provide additional downside pressure, while the improved balance sheet offers only limited offsetting support.

Positive Factors
Improved equity baseThe return to positive equity and moderate leverage indicates meaningful recapitalization and improved solvency versus prior years. This provides a stronger financial foundation for continued drug development and may reduce balance-sheet pressure over the next several quarters.
Negative Factors
No revenue baseThe absence of revenue means Helix BioPharma has not yet demonstrated commercial demand or an internally funded operating model. Its clinical-stage programs must therefore progress substantially before the business can build recurring sales and reduce dependence on external capital.

Helix BioPharma (HBP) vs. iShares MSCI Canada ETF (EWC)

-80%-60%-40%-20%0%20%40%TSE:HBP-65.16%EWC+21.04%Dec '25Jan '26Feb '26Mar '26Apr '26May '26Jun '26Jul '26Aug '26Sep '26Oct '26Nov '26
Market Cap
CAD 64.92M
Dividend Yield
―
Average Volume (3M)
9,910
Price to Earnings (P/E)
-19.3
Beta (1Y)
2.46
Revenue Growth
―
EPS Growth
54.45%
Country
Canada
Employees
7
Sector
Healthcare
Sector Strength
51
Industry
Biotechnology

Helix BioPharma Business Overview & Revenue Model

Company Description

Based in Richmond Hill, Canada, Helix BioPharma Corp. is a Canadian immune-oncology company focused on therapeutic development. The firm is progressing L-DOS47 for treating non-small cell lung cancer and is also working on V-DOS47, which targets the...

How the Company Makes Money

As a clinical-stage biopharmaceutical company, Helix BioPharma’s operations have typically not been driven by recurring product sales; instead, its funding and potential revenue sources generally come from capital raising (e.g., equity financings), a...

Helix BioPharma Financial Statement Overview

Summary

Very weak overall financial performance: revenue was zero, losses continued, and operating and free cash flow remained negative. Positive equity and relatively low current leverage provide limited support, but persistent cash burn and the history of negative equity justify the minimum score.

Income Statement

4Very Negative

Balance Sheet

55Neutral

Cash Flow

14Very Negative
Financial statement breakdown
BreakdownTTMJul 2026Jul 2025Jul 2024Jul 2023Oct 2022
Income Statement
Total Revenue000000
Gross Profit-5,000-4,000-10.00K-14.00K-13.00K-12.00K
EBITDA-3.72M-3.65M-5.21M-9.38M-6.31M-6.03M
Net Income-3.35M-3.35M-5.21M-9.26M-6.29M-6.08M
Balance Sheet
Total Assets19.38M19.38M18.80M1.49M1.03M3.73M
Cash, Cash Equivalents and Short-Term Investments804.00K804.00K65.00K1.08M808.00K3.25M
Total Debt4.16M4.16M336.00K002.47M
Total Liabilities5.17M5.17M3.22M1.58M1.87M3.41M
Stockholders Equity14.21M14.21M15.59M-90.00K-844.00K319.00K
Cash Flow
Free Cash Flow-4.32M-4.32M-3.83M-5.23M-5.54M-6.51M
Operating Cash Flow-4.32M-4.32M-3.83M-5.22M-5.53M-6.51M
Investing Cash Flow0017.00K-14.00K-5,0000
Financing Cash Flow5.05M5.05M2.80M5.51M3.09M6.21M

Helix BioPharma Technical Analysis

Technical Analysis SentimentNegative
Last Price0.85

Price Trends

50DMA1.10Negative
100DMA1.35Negative
200DMA1.57Negative

Market Momentum

MACD-0.06Negative
RSI40.09Neutral
STOCH50.30Neutral

Evaluating momentum and price trends is crucial in stock analysis to make informed investment decisions. For TSE:HBP, the sentiment is Negative. The current price of 0.85 is below the 20-day moving average (MA) of 0.93, below the 50-day MA of 1.10, and below the 200-day MA of 1.57, indicating a bearish trend. The MACD of -0.06 indicates Negative momentum. The RSI at 40.09 is Neutral, neither overbought nor oversold. The STOCH value of 50.30 is Neutral, not indicating any strong overbought or oversold conditions. Overall, these indicators collectively point to a Negative sentiment for TSE:HBP.

Helix BioPharma Peers Comparison

Overall Rating

UnderperformOutperform
Sector (51)

Financial Indicators

TSE:HBP against its peers
NameOverall RatingMarket CapP/E RatioROEDividend YieldRevenue GrowthEPS Growth
Sector *51Neutral$7.86B-0.30-43.30%2.27%22.53%-2.21%
TSE:MSCLTSE:MSCL44NeutralCAD 201.56M-3.17-77.81%――-32.01%
TSE:ARCHTSE:ARCH43NeutralCAD 63.18M-21.8874.79%――-15.53%
TSE:MDNATSE:MDNA40UnderperformCAD 29.88M-1.75-360.29%――-33.27%
TSE:HBPTSE:HBP38UnderperformCAD 64.92M-19.32-22.23%――54.45%

* Healthcare Sector Average

Performance Comparison

-50%0%50%TSE:HBPTSE:MSCLTSE:ARCHTSE:MDNATSE:METXTSE:ONCODec '25Jan '26Feb '26Mar '26Apr '26May '26Jun '26Jul '26Aug '26Sep '26Oct '26Nov '26
TSE:HBP and its peers over the selected period
Show on chartTickerCompany NamePriceChange% Change
TSE:HBPHelix Biopharma Corp.0.85-1.60-65.31%
TSE:MSCLSatellos Bioscience Inc.9.500.141.50%
TSE:ARCHArch Biopartners0.93-0.09-8.82%
TSE:MDNAMedicenna Therapeutics0.39-1.07-73.63%
TSE:METXME Therapeutics Holdings, Inc.1.00-3.00-75.00%
TSE:ONCOOnco-Innovations Ltd.1.470.000.00%

Helix BioPharma Corporate Events

Business Operations and StrategyExecutive/Board ChangesFinancial Disclosures

Helix BioPharma Narrows Fiscal 2026 Loss as It Bolsters Oncology Pipeline and Governance

Positive
Oct 30, 2026

Helix BioPharma reported a narrowed net loss of $3.35 million for fiscal 2026, down from $5.21 million a year earlier, reflecting disciplined expense control as it advances its oncology pipeline. The reduced loss per share to $0.04 from $0.09 undersc...

Business Operations and StrategyExecutive/Board Changes

Helix BioPharma Revamps Board to Bolster Governance and Oncology Focus

Positive
Sep 28, 2026

Helix BioPharma has overhauled its board of directors, appointing experienced life sciences and capital markets executives Karen Krumeich, Jamieson Bondarenko, Charmaine Lykins and scientist Dirk Brockstedt, with Krumeich also becoming chair of the b...

Business Operations and StrategyExecutive/Board Changes

Helix BioPharma Taps Veteran Oncologist Markus Loeffler as CMO for Next Clinical Phase

Positive
Aug 17, 2026

Helix BioPharma Corp. is a clinical-stage oncology company developing novel therapies for difficult-to-treat cancers, with a focus on underserved patient populations. Its pipeline is led by L-DOS47, an antibody-enzyme conjugate being advanced as a co...

Business Operations and StrategyExecutive/Board Changes

Helix BioPharma Reshapes Board to Align with Oncology Growth Strategy

Positive
Aug 14, 2026

Helix BioPharma Corp., a Vancouver-based clinical-stage oncology firm developing novel cancer therapies, has adjusted its board composition following its recent strategic expansion of pipeline assets. The move comes as the company continues to advanc...

Glossary
BuyA stock rated as a "Buy" is expected to perform better than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock is likely to deliver higher returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
HoldA stock rated as a "Hold" is expected to perform in line with the overall market or a specific benchmark. This rating indicates that the stock is neither particularly compelling nor unfavorable for investment. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
SellA stock rated as a "Sell" is expected to perform worse than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock may deliver lower returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.

Disclaimer

This AI Analyst Stock Report is automatically generated by our AI systems using advanced algorithms and publicly available financial, technical, and market data. While the information provided aims to be accurate and insightful, it is intended for informational purposes only and should not be considered financial advice. Any content created by an AI (Artificial Intelligence) system may contain inaccuracies and/or contain errors. Investing in stocks carries inherent risks, and past performance is not indicative of future results. This report does not account for your personal financial circumstances, objectives, or risk tolerance. Always conduct your own research or consult with a qualified financial advisor before making investment decisions. The analysis and recommendations provided are based on historical and current data and may not fully reflect future market conditions or unexpected developments. Neither the creators of this report nor its affiliated entities guarantee the accuracy, completeness, or reliability of the information presented. Use this report at your own discretion and risk.

Date of analysis: Nov 11, 2026