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ProKidney (PROK) AI Stock Analysis

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PROK

ProKidney

(NASDAQ:PROK)

Select Model
Rating:44Neutral
Price Target:$1.00â–¼(-11.50% Downside)
Action:reiterated
Date:11/10/26

The score is primarily pressured by very weak financial performance (minimal revenue, large losses, and substantial ongoing cash burn with multi-year negative equity), alongside bearish technicals (price below key moving averages and negative MACD). Corporate updates around rilparencel are a positive offset, but valuation support is limited given negative earnings and no dividend.

Positive Factors
Clinical development progressProgress into Phase 3 gives rilparencel a more advanced development profile and provides a defined path toward potential commercialization. Reported kidney-function stabilization in earlier studies supports the therapy’s clinical rationale, although final efficacy and approval remain unproven.
Negative Factors
Substantial cash burnThe company is not self-funding and continues to consume cash at a substantial rate, leaving ongoing operations and clinical development dependent on external capital. Persistent outflows reduce financial flexibility and increase the importance of successful financing and future clinical execution.

ProKidney (PROK) vs. SPDR S&P 500 ETF (SPY)

-60%-40%-20%0%20%PROK-53.11%SPY+14.28%Dec '25Jan '26Feb '26Mar '26Apr '26May '26Jun '26Jul '26Aug '26Sep '26Oct '26Nov '26
Market Cap
$379.97M
Dividend Yield
―
Average Volume (3M)
1.41M
Price to Earnings (P/E)
-2.0
Beta (1Y)
2.20
Revenue Growth
55.22%
EPS Growth
2.13%
Country
US
Employees
231
Sector
Healthcare
Sector Strength
51
Industry
Biotechnology

ProKidney Business Overview & Revenue Model

Company Description

ProKidney Corp. is a biotechnology firm currently in the clinical trial phase, specializing in the development of innovative cell-based treatments. Their flagship product is Renal Autologous Cell Therapy (RAC-T), a unique cellular admixture derived f...

ProKidney Financial Statement Overview

Summary

Financial performance is very weak: minimal and volatile revenue (~$0.8M TTM) against very large losses (~$86.7M TTM net loss) and heavy cash burn (TTM operating cash flow about -$141.2M; free cash flow about -$155.9M). Low debt (~$2.4M TTM) helps near-term leverage risk, but multi-year negative equity is a significant balance-sheet concern and implies continued financing needs.

Income Statement

12Very Negative

Balance Sheet

44Neutral

Cash Flow

18Very Negative
Financial statement breakdown
BreakdownTTMDec 2025Mar 2025Dec 2023Dec 2022Dec 2021
Income Statement
Total Revenue818.00K893.00K76.00K000
Gross Profit-2.07M893.00K76.00K000
EBITDA-159.91M-144.62M-158.49M-125.59M-143.99M-53.12M
Net Income-86.71M-68.99M-61.19M-35.47M-108.03M-55.15M
Balance Sheet
Total Assets249.02M335.57M441.07M420.55M518.00M40.30M
Cash, Cash Equivalents and Short-Term Investments181.56M270.02M358.29M362.95M490.25M20.56M
Total Debt3.52M4.04M3.24M4.41M2.40M1.33M
Total Liabilities26.18M34.78M39.44M29.22M13.06M13.38M
Stockholders Equity-883.53M-1.01B-994.95M-1.10B-1.10B26.92M
Cash Flow
Free Cash Flow-159.73M-135.31M-155.86M-124.27M-78.94M-55.49M
Operating Cash Flow-141.17M-120.12M-126.35M-90.07M-77.09M-50.30M
Investing Cash Flow104.74M103.97M20.41M-329.98M-1.74M-5.19M
Financing Cash Flow26.35M25.57M144.41M-9.55M548.52M71.47M

ProKidney Technical Analysis

Technical Analysis SentimentNegative
Last Price1.13

Price Trends

50DMA1.58Negative
100DMA1.62Negative
200DMA1.78Negative

Market Momentum

MACD-0.13Positive
RSI35.08Neutral
STOCH37.41Neutral

Evaluating momentum and price trends is crucial in stock analysis to make informed investment decisions. For PROK, the sentiment is Negative. The current price of 1.13 is below the 20-day moving average (MA) of 1.32, below the 50-day MA of 1.58, and below the 200-day MA of 1.78, indicating a bearish trend. The MACD of -0.13 indicates Positive momentum. The RSI at 35.08 is Neutral, neither overbought nor oversold. The STOCH value of 37.41 is Neutral, not indicating any strong overbought or oversold conditions. Overall, these indicators collectively point to a Negative sentiment for PROK.

ProKidney Risk Analysis

ProKidney disclosed 92 risk factors in its most recent earnings report. ProKidney reported the most risks in the "Tech & Innovation" category.

Higher RiskSector Avg.Lower RiskFinance & CorporateTech & InnovationLegal & RegulatoryProductionAbility to SellMacro & Political
Tech & Innovation - Risks related to the company’s reliance on technology and ability to make innovative products

Latest Risks Added

3 New Risks
1.Our recurring losses, negative cash flows, and accumulated deficit raise substantial doubt about our ability to continue as a going concern.Q2, 2026
2.The stock market is volatile, and fluctuations in our operating results, removal from various indices and other factors could cause our stock price to decline.Q4, 2025
3.Our failure to meet the continued listing requirements of NASDAQ could result in the de-listing of our Class A common stock.Q4, 2025

ProKidney Peers Comparison

Overall Rating

UnderperformOutperform
Sector (51)

Financial Indicators

PROK against its peers
NameOverall RatingMarket CapP/E RatioROEDividend YieldRevenue GrowthEPS Growth
GYREGYRE56Neutral$487.81M-15.27-22.44%―13.51%-458.42%
Sector *51Neutral$7.86B-0.30-43.30%2.27%22.53%-2.21%
DMACDMAC51Neutral$521.46M-13.42-77.68%――-3.42%
ARDXARDX49Neutral$756.63M-13.94-35.30%―17.57%4.82%
PROKPROK44Neutral$335.63M-1.988.83%―55.22%2.13%
SANASANA44Neutral$728.11M-4.32-97.08%――45.15%
AKBAAKBA42Neutral$150.44M-3.58-169.15%―-12.38%-118.99%

* Healthcare Sector Average

Performance Comparison

-50%0%50%PROKGYREAKBAARDXDMACSANADec '25Jan '26Feb '26Mar '26Apr '26May '26Jun '26Jul '26Aug '26Sep '26Oct '26Nov '26
PROK and its peers over the selected period
Show on chartTickerCompany NamePriceChange% Change
PROKProkidney Corp.1.13-1.15-50.44%
GYREGyre Therapeutics Inc4.26-3.82-47.28%
AKBAAkebia Therapeutics0.57-1.19-67.44%
ARDXArdelyx Inc3.13-2.70-46.31%
DMACDiamedica Therapeutics9.664.2478.23%
SANASana Biotechnology, Inc.2.29-1.37-37.43%

ProKidney Corporate Events

Business Operations and StrategyProduct-Related Announcements

ProKidney Updates Investor Presentation on Rilparencel Development

Positive
Nov 9, 2026

In November 2026, ProKidney updated an investor presentation for use in interactions with investors and analysts. The presentation described rilparencel’s clinical development, including reported kidney-function stabilization in multiple Phase 2 stud...

Private Placements and FinancingRegulatory Filings and Compliance

ProKidney Announces At-the-Market Equity Offering Agreement

Neutral
Oct 29, 2026

On October 29, 2026, ProKidney Corp. entered into an Open Market Sale Agreement with Jefferies LLC, allowing the company to sell Class A common stock from time to time in an at-the-market offering on Nasdaq and other permitted venues. ProKidney filed...

Glossary
BuyA stock rated as a "Buy" is expected to perform better than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock is likely to deliver higher returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
HoldA stock rated as a "Hold" is expected to perform in line with the overall market or a specific benchmark. This rating indicates that the stock is neither particularly compelling nor unfavorable for investment. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
SellA stock rated as a "Sell" is expected to perform worse than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock may deliver lower returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.

Disclaimer

This AI Analyst Stock Report is automatically generated by our AI systems using advanced algorithms and publicly available financial, technical, and market data. While the information provided aims to be accurate and insightful, it is intended for informational purposes only and should not be considered financial advice. Any content created by an AI (Artificial Intelligence) system may contain inaccuracies and/or contain errors. Investing in stocks carries inherent risks, and past performance is not indicative of future results. This report does not account for your personal financial circumstances, objectives, or risk tolerance. Always conduct your own research or consult with a qualified financial advisor before making investment decisions. The analysis and recommendations provided are based on historical and current data and may not fully reflect future market conditions or unexpected developments. Neither the creators of this report nor its affiliated entities guarantee the accuracy, completeness, or reliability of the information presented. Use this report at your own discretion and risk.

Date of analysis: Nov 10, 2026