OSE Immunotherapeutics SA (ORPOF) Price & Analysis
ORPOF Stock Chart & Stats
- Day’s Range
- $4.43 - $4.43
- 52-Week Range
- $4.43 - $11.60
- Previous Close
- $4.43
- Volume
- N/A
- Average Volume (3M)
- 0
- Market Cap
- $51.46M
- Enterprise Value
- $128.21M
- Total Cash (Recent Filing)
- $22.65M
- Total Debt (Recent Filing)
- $35.38M
- Price to Earnings (P/E)
- ―
- Beta
- 0.40
- Next Earnings
- Mar 31, 2027
- EPS Estimate
- N/A
- Next Dividend Ex-Date
- N/A
- Dividend Yield
- N/A
Bulls Say, Bears Say
Bulls Say
Prior-year Operating Strength
The company demonstrated that its development and partnering model can generate substantial revenue and profitability under favorable conditions. Although performance later weakened, the 2024 result provides evidence of commercial potential and an ability to convert successful programs or transactions into meaningful operating value.
Historical Cash Generation
Strong positive operating and free cash flow in 2024 shows that OSE has previously been capable of producing internal funding from its activities. That history supports the potential to finance research and development without relying exclusively on external capital when operating results and program economics are favorable.
Improved Leverage Versus 2023
Balance-sheet leverage is still substantial, but the improvement from 2023 indicates some progress in reducing relative financial pressure. This provides a stronger starting point for capital allocation and partnership discussions than the earlier capital structure, provided the company can prevent further equity erosion.
Bears Say
Severe Revenue Contraction
The dramatic revenue decline indicates that recent operating performance is highly dependent on irregular program or transaction outcomes rather than a steadily compounding commercial base. A very small revenue platform reduces funding capacity for clinical development and makes future results unusually sensitive to individual milestones.
Large Losses And Unstable Earnings
A large net loss combined with deeply negative operating profitability places sustained pressure on the company’s capital base. Unless operating performance improves, ongoing research and development will need to be supported by financing, partnerships, or other non-operating sources, limiting strategic flexibility.
Cash-burn And Funding Dependence
The reversal from strong positive cash generation in 2024 to substantial cash burn in 2025 materially increases dependence on external funding. Persistent negative free cash flow could constrain clinical investment, increase financing requirements, and amplify dilution or other capital-raising pressure over coming quarters.
OSE Immunotherapeutics SA News
ORPOF FAQ
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Company Description
OSE Immunotherapeutics SA
Based in Nantes, France, OSE Immunotherapeutics S.A. specializes in creating immunotherapies designed to activate or regulate the immune system. Their work primarily targets both immuno-oncology and autoimmune diseases. Their advanced pipeline features Tedopi, which is currently in Phase III clinical trials for non-small cell lung cancer, with further Phase II investigations ongoing for pancreatic and ovarian cancers. For infectious diseases, they are developing CoVepiT, a prophylactic vaccine against the SARS-CoV-2 virus. In oncology, their portfolio also includes BI 765063, in Phase I for solid tumors, and BiCKI, an innovative bispecific checkpoint inhibitor platform. BiCKI is engineered to counteract cancer's primary and secondary resistance mechanisms by targeting PD-1 alongside other novel pathways. Addressing autoimmune and inflammatory conditions, OSE Immunotherapeutics is progressing OSE-127, a humanized monoclonal antibody in Phase II trials for both ulcerative colitis and Sjögren's Syndrome. FR104 is undergoing Phase I development for rheumatoid arthritis, while OSE-230, an agonist antibody against ChemR23, aims to resolve chronic inflammation. The company maintains strategic collaborations and partnerships with organizations such as GERCOR, Boehringer Ingelheim, Servier, and Chong Kun Dang Pharmaceutical Corporation. OSE Immunotherapeutics S.A. was formerly known as OSE Pharma SA until its name change in May 2016.
- Sector
- Healthcare
- Industry
- Biotechnology
- CEO
- Marc Le Bozec
- Employees
- 64
- Website
- www.ose-immuno.com
- Address
- 22, boulevard Benoni Goullin, Nantes, PL, 44200, FR
OSE Immunotherapeutics SA (ORPOF) Earnings & Revenues
Technical Analysis
Overall Consensus
| Indicator | Bullish | Neutral | Bearish |
|---|---|---|---|
| Overall Consensus | 1 | 0 | 13 |
| Technical Analysis | 0 | 0 | 2 |
| Moving Averages | 1 | 0 | 11 |








