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NeOnc Technologies Holdings, Inc. (NTHI) AI Stock Analysis

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NTHI

NeOnc Technologies Holdings, Inc.

(NASDAQ:NTHI)

Select Model
Rating:44Neutral
Price Target:$2.50â–¼(-23.31% Downside)
Action:reiterated
Date:10/23/26

The score is primarily weighed down by extremely weak financial performance (near-zero revenue, large and rising losses, heavy cash burn, and deeply negative equity) and a bearish technical trend (below major moving averages with negative MACD). Positive corporate developments in the clinical/regulatory pipeline and recent financing provide some support, but they do not outweigh the current financial strain and funding/dilution risk.

Positive Factors
Clinical progress in brain oncologyThe positive Phase 2a readout provides clinical validation for NEO100 in a high-unmet-need glioma setting, with results materially above the cited benchmark. If confirmed in further studies, this could support regulatory advancement, differentiated positioning, and future commercial potential.
Negative Factors
Pre-revenue operating modelThe company has not yet established meaningful revenue to absorb its operating expenses, leaving its financial profile dependent on successful clinical execution and future financing. Continued large losses before commercialization increase the time and capital required to reach a sustainable business model.

NeOnc Technologies Holdings, Inc. (NTHI) vs. SPDR S&P 500 ETF (SPY)

-80%-60%-40%-20%0%20%NTHI-68.92%SPY+11.79%Dec '25Jan '26Feb '26Mar '26Apr '26May '26Jun '26Jul '26Aug '26Sep '26Oct '26
Market Cap
$93.91M
Dividend Yield
―
Average Volume (3M)
210.46K
Price to Earnings (P/E)
-1.5
Beta (1Y)
1.57
Revenue Growth
-100.00%
EPS Growth
18.94%
Country
US
Employees
5
Sector
General
Sector Strength
55
Industry
Biotechnology

NeOnc Technologies Holdings, Inc. Business Overview & Revenue Model

Company Description

NeOnc Technologies Holdings, Inc. is a clinical-stage biopharmaceutical company. It develops novel molecular technology that provides enhanced targeted delivery of technologies for treating central nervous system diseases. The company was founded in...

NeOnc Technologies Holdings, Inc. Financial Statement Overview

Summary

Financials reflect an early-stage, pre-revenue profile with severe operating weakness: revenue is effectively immaterial while net losses are very large and worsened sharply year-over-year. Cash flow is deeply negative with significant and increasing operating/free cash burn, and stockholders’ equity is deeply negative, increasing financing and dilution risk despite modest TTM debt and some asset growth.

Income Statement

4Very Negative

Balance Sheet

8Very Negative

Cash Flow

6Very Negative
Financial statement breakdown
BreakdownTTMMar 2026Dec 2024Dec 2023Dec 2022Dec 2021
Income Statement
Total Revenue039.99K83.00K70.46K20.00K0
Gross Profit-57.52K39.99K83.00K70.46K20.00K0
EBITDA-43.63M-59.61M-9.10M-12.20M-2.85M-3.26M
Net Income-47.20M-62.15M-11.90M-14.92M-3.05M-3.38M
Balance Sheet
Total Assets5.23M2.82M3.42M1.27M728.68K32.49K
Cash, Cash Equivalents and Short-Term Investments1.97M58.73K64.89K31.86K633.30K25.03K
Total Debt328.22K6.31M24.72K6.61M50.00K1.15M
Total Liabilities23.76M20.33M8.92M15.25M2.30M2.65M
Stockholders Equity-18.53M-17.51M-5.50M-13.99M-1.58M-2.62M
Cash Flow
Free Cash Flow-21.16M-20.86M-4.21M-1.88M-881.74K-396.69K
Operating Cash Flow-21.16M-20.36M-4.21M-1.88M-881.74K-396.69K
Investing Cash Flow0-500.00K0000
Financing Cash Flow23.51M20.86M4.25M1.28M1.49M250.00K

NeOnc Technologies Holdings, Inc. Technical Analysis

Technical Analysis SentimentNeutral
Last Price3.26

Price Trends

50DMA3.48Negative
100DMA3.80Negative
200DMA5.47Negative

Market Momentum

MACD-0.06Negative
RSI54.73Neutral
STOCH47.06Neutral

Evaluating momentum and price trends is crucial in stock analysis to make informed investment decisions. For NTHI, the sentiment is Neutral. The current price of 3.26 is above the 20-day moving average (MA) of 2.86, below the 50-day MA of 3.48, and below the 200-day MA of 5.47, indicating a neutral trend. The MACD of -0.06 indicates Negative momentum. The RSI at 54.73 is Neutral, neither overbought nor oversold. The STOCH value of 47.06 is Neutral, not indicating any strong overbought or oversold conditions. Overall, these indicators collectively point to a Neutral sentiment for NTHI.

NeOnc Technologies Holdings, Inc. Risk Analysis

NeOnc Technologies Holdings, Inc. disclosed 83 risk factors in its most recent earnings report. NeOnc Technologies Holdings, Inc. reported the most risks in the "Tech & Innovation" category.

Higher RiskSector Avg.Lower RiskFinance & CorporateTech & InnovationLegal & RegulatoryProductionAbility to SellMacro & Political
Tech & Innovation - Risks related to the company’s reliance on technology and ability to make innovative products

Latest Risks Added

0 New Risks

NeOnc Technologies Holdings, Inc. Peers Comparison

Overall Rating

UnderperformOutperform
Sector (55)

Financial Indicators

NTHI against its peers
NameOverall RatingMarket CapP/E RatioROEDividend YieldRevenue GrowthEPS Growth
Sector *55Neutral$6.65B3.83-15.92%6.20%10.91%7.18%
CLDICLDI46Neutral$2.53M-0.01-372.86%――53.95%
NTHINTHI44Neutral$93.91M-1.47309.09%―-100.00%18.94%
GTBPGTBP42Neutral$10.96M-0.05-443.08%――75.09%
GOVXGOVX39Underperform$1.70M-0.01-743.66%―-100.00%77.63%

* General Sector Average

Performance Comparison

-100%-50%0%NTHIGOVXGTBPCLDIDec '25Jan '26Feb '26Mar '26Apr '26May '26Jun '26Jul '26Aug '26Sep '26Oct '26
NTHI and its peers over the selected period
Show on chartTickerCompany NamePriceChange% Change
NTHINeOnc Technologies Holdings, Inc.3.26-6.93-68.01%
GOVXGeovax Labs, Inc.0.17-14.18-98.83%
GTBPGt Biopharma, Inc.5.32-10.26-65.85%
CLDICalidi Biotherapeutics, Inc.0.69-23.79-97.19%

NeOnc Technologies Holdings, Inc. Corporate Events

Business Operations and Strategy

NeOnc Technologies Expands Abu Dhabi Oncology Collaboration Efforts

Positive
Oct 22, 2026

In October 2026, NeOnc Technologies reported early clinical improvement in a critically ill three-year-old boy in Abu Dhabi with an aggressive brain tumor, treated with investigational intranasal NEO100 under its Compassionate Care program. The physi...

Business Operations and StrategyExecutive/Board ChangesRegulatory Filings and Compliance

NeOnc Technologies boosts Gulf profile with Abu Dhabi summit

Positive
Oct 15, 2026

On October 9, 2026, NeOnc Technologies Holdings, Inc. reported the resignation of Class I director Steven L. Giannotta, M.D., from its board, noting his departure did not stem from any dispute and that he will continue contributing on the company&#82...

Business Operations and StrategyRegulatory Filings and Compliance

NeOnc Plans FDA End-of-Phase 1 Meeting for NEO212

Positive
Sep 28, 2026

NeOnc Technologies announced on September 28, 2026, that it is scheduled to meet in person with the U.S. Food and Drug Administration on November 17, 2026, for an End-of-Phase 1 Type B meeting regarding its investigational CNS cancer therapy NEO212....

Business Operations and StrategyPrivate Placements and FinancingRegulatory Filings and Compliance

NeOnc Simplifies Capital Structure Amid CNS Oncology Focus

Positive
Sep 21, 2026

NeOnc Technologies Holdings, Inc., a Nasdaq-listed, multi-Phase 2 clinical-stage biopharmaceutical company, is developing novel therapies for central nervous system cancers using its NEO platform to address blood-brain barrier challenges. Its lead ca...

Business Operations and StrategyPrivate Placements and Financing

NeOnc CEO Boosts Stake After Recent Offering

Positive
Sep 17, 2026

On September 16, 2026, NeOnc Technologies Holdings reported that Executive Chairman, President and CEO Amir F. Heshmatpour bought an additional 35,000 shares of company stock on September 15 for about $115,400 at a weighted average price of roughly $...

Business Operations and StrategyPrivate Placements and Financing

NeOnc Technologies Announces $15 Million Registered Direct Offering

Positive
Sep 10, 2026

On September 8 and 9, 2026, NeOnc Technologies Holdings, Inc. entered into definitive securities purchase and placement agency agreements for a registered direct offering with new and existing healthcare-focused institutional investors. The deal cove...

Executive/Board ChangesShareholder Meetings

NeOnc Technologies Holds 2026 Annual Stockholder Meeting

Positive
Aug 20, 2026

NeOnc Technologies Holdings, Inc. held its 2026 annual meeting of stockholders via live webcast on August 14, 2026, with 77.92% of eligible common shares represented, establishing a quorum under its bylaws. Stockholders elected two Class I directors,...

Business Operations and StrategyProduct-Related AnnouncementsRegulatory Filings and Compliance

NeOnc Announces Positive Phase 2a Data in Brain Cancer

Positive
Aug 13, 2026

On August 12, 2026, NeOnc Technologies hosted an investor conference call to present top-line Phase 2a results from its NEO100-01 trial in recurrent IDH1-mutant high-grade glioma, reporting that the study met its primary endpoint with a median overal...

Business Operations and Strategy

NeOnc Technologies Reports Positive Phase 2a Glioma Results

Positive
Aug 12, 2026

On August 12, 2026, NeOnc Technologies reported positive topline Phase 2a results from its NEO100-01 study of intranasal NEO100 in patients with recurrent or progressive Grade III and Grade IV IDH1-mutant glioma, a setting with no approved targeted t...

Business Operations and StrategyExecutive/Board ChangesFinancial DisclosuresRegulatory Filings and Compliance

NeOnc Highlights Q2 Results and CNS Oncology Progress

Neutral
Aug 10, 2026

NeOnc reported its second-quarter 2026 results on August 10, 2026, alongside clinical and regulatory milestones for its NEO100 and NEO212 programs, underscoring a strategic focus on advancing central nervous system cancer treatments. The company comp...

Glossary
BuyA stock rated as a "Buy" is expected to perform better than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock is likely to deliver higher returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
HoldA stock rated as a "Hold" is expected to perform in line with the overall market or a specific benchmark. This rating indicates that the stock is neither particularly compelling nor unfavorable for investment. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
SellA stock rated as a "Sell" is expected to perform worse than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock may deliver lower returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.

Disclaimer

This AI Analyst Stock Report is automatically generated by our AI systems using advanced algorithms and publicly available financial, technical, and market data. While the information provided aims to be accurate and insightful, it is intended for informational purposes only and should not be considered financial advice. Any content created by an AI (Artificial Intelligence) system may contain inaccuracies and/or contain errors. Investing in stocks carries inherent risks, and past performance is not indicative of future results. This report does not account for your personal financial circumstances, objectives, or risk tolerance. Always conduct your own research or consult with a qualified financial advisor before making investment decisions. The analysis and recommendations provided are based on historical and current data and may not fully reflect future market conditions or unexpected developments. Neither the creators of this report nor its affiliated entities guarantee the accuracy, completeness, or reliability of the information presented. Use this report at your own discretion and risk.

Date of analysis: Oct 22, 2026