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Jaguar Animal Health (JAGX) AI Stock Analysis

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JAGX

Jaguar Animal Health

(NASDAQ:JAGX)

Select Model
Rating:42Neutral
Price Target:$0.46▼(-3.94% Downside)
Action:upgraded
Date:11/03/26

The score is primarily constrained by weak financial performance (continued losses, thin equity, and TTM cash burn) and very bearish technicals (price far below key moving averages with negative MACD). Corporate actions provide some near-term liquidity relief but are offset by dilution and governance frictions, while valuation inputs are not supportive based on the provided P/E and missing dividend yield.

Positive Factors
Specialized Animal-Health PortfolioA commercial portfolio addressing gastrointestinal conditions across companion animals and livestock gives Jaguar an established operating base and a focused therapeutic identity. Plant-derived formulations and specialized veterinary applications may support differentiated positioning as the company expands adoption.
Negative Factors
Persistent Operating LossesDeep operating and net losses show that the current cost structure is not yet aligned with the company’s revenue base. Continued cash consumption could require additional financing, limiting strategic flexibility and delaying the point at which strong gross margins translate into sustainable earnings.

Jaguar Animal Health (JAGX) vs. SPDR S&P 500 ETF (SPY)

-100%-75%-50%-25%0%25%JAGX-99.93%SPY+14.30%Dec '25Jan '26Feb '26Mar '26Apr '26May '26Jun '26Jul '26Aug '26Sep '26Oct '26Nov '26
Market Cap
$1.12M
Dividend Yield
―
Average Volume (3M)
2.33M
Price to Earnings (P/E)
0.0
Beta (1Y)
3.75
Revenue Growth
135.52%
EPS Growth
85.50%
Country
US
Employees
47
Sector
Healthcare
Sector Strength
51
Industry
Biotechnology

Jaguar Animal Health Business Overview & Revenue Model

Company Description

Jaguar Health, Inc., a commercial-stage pharmaceutical firm, specializes in developing prescription therapies for both human and animal patients afflicted by gastrointestinal ailments, particularly chronic and severe diarrhea. Its operations are stru...

Jaguar Animal Health Earnings Call Summary

Earnings Call Date:Apr 07, 2026(Q4-2025)|% Change Since:-99.69%|Next Earnings Date:May 24, 2019
Earnings Call SentimentNeutral

The call presented meaningful strategic and clinical positives — a sizable non-dilutive upfront/licensing arrangement, manufacturing revenue upside, and compelling proof-of-concept data with 12%–37% reductions in parenteral support and a targeted NDA timeline (H1 2027) for MVID. However, these positives are balanced by near-term commercial and financial challenges: YoY revenue decline, sustained and growing operating losses (net loss to $53.6M; Non-GAAP recurring EBITDA loss $48.1M), declining Mytesi prescription volumes, and increased dependency on partner milestone payments and manufacturing revenue under the out-license. Overall, the call communicated promising development and BD catalysts that could be transformative long term but also highlighted significant short-term financial pressures and commercialization trade-offs.

Positive Updates

Non-Dilutive Licensing Deal with Future Pak
Closed U.S. out-license for Mytesi and Canalevia-CA1 with $18M upfront (company reported $16M received at signing, $2M conditional), additional ~$20M in potential milestone and future payments, and roughly $3M–$4M of additional payments already received. Jaguar will continue to manufacture crofelemer and recognize manufacturing revenue; the deal provides immediate non-dilutive cash to fund rare-disease development.

Negative Updates

Declining Mytesi Prescription Volume
Mytesi prescription volume declined ~3.7% in 2025 vs 2024, declined ~5.8% in Q4 2025 vs Q3 2025, and declined ~12.2% in Q4 2025 vs Q4 2024. Company notes specialty pharmacy inventory dynamics contribute to variability between prescription and invoiced sales volume.

Company Guidance

The company’s guidance centers on “continued business development” in 2026 with near-term clinical, regulatory and BD catalysts over the next 6–12 months and a clear goal to license its crofelemer rare-disease program: target filing of an NDA for MVID in first half of 2027 (MVID global prevalence ≈200 patients) following completion of a fully enrolled placebo‑controlled trial (with ongoing treatment‑only extension), pursuit of FDA Breakthrough designation and EMA PRIME, and parallel Phase II randomized double‑blind placebo‑controlled development in short bowel syndrome‑IF (SBS‑IF; U.S. patient estimate ≈12,000) where third‑party market estimates put opportunity at ~$8 billion; proof‑of‑concept investigator data in three pediatric IF patients showed parenteral‑support reductions of 12%–37% (12.5%–15.6% in two SBS patients, ~37% in one MVID), with even 5% reductions described as meaningful; financial guidance emphasizes non‑dilutive funding (Future Pak licensing: $18M upfront with $16M received to date, $2M conditional, ~$20M in potential milestones and >$3M additional payments reported, Future Pak also paid $3M tied to termination of a buy‑back provision), Jaguar to remain manufacturer and recognize manufacturing revenue, Q4 2025 net revenue ≈$3.2M (+5% vs Q3 2025 $3.1M; −8% vs Q4 2024 $3.5M), 2025 total net revenue ≈$11.5M (≈$11.2M from Mytesi and Canalevia‑CA1), Mytesi prescription volume down ~3.7% in 2025 vs 2024 (Q4 2025 vs Q3 2025 down ~5.8%; Q4 2025 vs Q4 2024 down ~12.2%), loss from operations increased $15.1M to $45.9M in 2025, Non‑GAAP Recurring EBITDA net loss $48.1M (2025) vs $35.9M (2024), net loss attributable to common shareholders $53.6M (2025) vs $38.5M (2024), and the company expects these clinical, regulatory and BD milestones to drive partnership discussions and additional non‑dilutive funding.

Jaguar Animal Health Financial Statement Overview

Summary

Revenue scaled materially over multi-year periods and TTM gross margin is strong (~82%), but profitability remains deeply negative and the latest period shows a sharp revenue decline versus the prior comparable period. Balance sheet leverage has improved with debt down to ~$16.7M TTM, yet equity is thin (~$6.6M) and leverage remains high (~3.4x debt-to-equity). Cash flow turned negative again in TTM (operating and free cash flow about -$6.7M/-$6.8M), implying renewed funding pressure.

Income Statement

18Very Negative

Balance Sheet

27Negative

Cash Flow

22Negative
Financial statement breakdown
BreakdownTTMMar 2026Mar 2025Mar 2024Dec 2022Dec 2021
Income Statement
Total Revenue27.82M11.51M11.69M9.76M11.96M4.33M
Gross Profit22.89M7.74M9.73M7.72M9.94M2.00M
EBITDA-39.97M-51.73M-36.66M-31.53M-33.38M-42.37M
Net Income-36.65M-53.43M-38.49M-41.30M-47.45M-52.59M
Balance Sheet
Total Assets34.19M38.32M53.42M50.76M47.45M53.27M
Cash, Cash Equivalents and Short-Term Investments6.59M968.00K8.00M6.47M5.47M17.05M
Total Debt16.65M43.61M36.53M37.09M34.84M29.36M
Total Liabilities29.27M57.01M46.93M45.87M48.81M41.41M
Stockholders Equity6.62M-17.29M7.29M4.96M-657.00K11.61M
Cash Flow
Free Cash Flow-6.76M-23.71M-29.61M-33.24M-34.78M-34.98M
Operating Cash Flow-6.74M-23.69M-29.38M-33.24M-33.10M-34.97M
Investing Cash Flow-41.00K149.00K-231.00K0-1.68M-6,000
Financing Cash Flow11.30M-44.33M31.20M34.23M23.18M43.94M

Jaguar Animal Health Technical Analysis

Technical Analysis SentimentNegative
Last Price0.48

Price Trends

50DMA3.42Negative
100DMA9.81Negative
200DMA74.01Negative

Market Momentum

MACD-1.03Negative
RSI36.21Neutral
STOCH5.40Positive

Evaluating momentum and price trends is crucial in stock analysis to make informed investment decisions. For JAGX, the sentiment is Negative. The current price of 0.48 is below the 20-day moving average (MA) of 1.66, below the 50-day MA of 3.42, and below the 200-day MA of 74.01, indicating a bearish trend. The MACD of -1.03 indicates Negative momentum. The RSI at 36.21 is Neutral, neither overbought nor oversold. The STOCH value of 5.40 is Positive, not indicating any strong overbought or oversold conditions. Overall, these indicators collectively point to a Negative sentiment for JAGX.

Jaguar Animal Health Risk Analysis

Jaguar Animal Health disclosed 70 risk factors in its most recent earnings report. Jaguar Animal Health reported the most risks in the "Finance & Corporate" category.

Higher RiskSector Avg.Lower RiskFinance & CorporateTech & InnovationLegal & RegulatoryProductionAbility to SellMacro & Political
Finance & Corporate - Financial and accounting risks. Risks related to the execution of corporate activity and strategy

Latest Risks Added

2 New Risks
1.Our failure to meet the continued listing requirements of The Nasdaq Capital Market could result in a delisting of our common stock.Q1, 2026
2.The growing use of AI systems to automate processes, analyze data, and support decision-making poses inherent risks.Q4, 2023

Jaguar Animal Health Peers Comparison

Overall Rating

UnderperformOutperform
Sector (51)

Financial Indicators

JAGX against its peers
NameOverall RatingMarket CapP/E RatioROEDividend YieldRevenue GrowthEPS Growth
Sector *51Neutral$7.86B-0.30-43.30%2.27%22.53%-2.21%
JAGXJAGX42Neutral$5.83M0.00762.51%―135.52%85.50%
EVGNEVGN40Underperform$6.72M-0.37761.97%―-80.59%59.44%
CODXCODX39Underperform$2.74M-0.01-322.92%―28.89%34.53%
GOVXGOVX39Underperform$32.67M-0.01-743.66%―-100.00%77.63%

* Healthcare Sector Average

Performance Comparison

-100%-75%-50%-25%0%JAGXEVGNGOVXCODXDec '25Jan '26Feb '26Mar '26Apr '26May '26Jun '26Jul '26Aug '26Sep '26Oct '26Nov '26
JAGX and its peers over the selected period
Show on chartTickerCompany NamePriceChange% Change
JAGXJaguar Animal Health Inc.0.48-675.45-99.93%
EVGNEvogene Ltd.0.40-0.81-67.36%
GOVXGeovax Labs, Inc.2.16-268.50-99.20%
CODXCo-Diagnostics0.28-9.66-97.21%

Jaguar Animal Health Corporate Events

Private Placements and FinancingShareholder MeetingsStock Split

Jaguar Health Stockholders Approve Six Proposals at Special Meeting

Neutral
Nov 6, 2026

On November 6, 2026, Jaguar Health stockholders approved all six proposals at a special meeting. The measures approved common-stock issuance linked to Series Q preferred stock and CVP debt, repriced investor warrants to $1 per share, expanded the 201...

Dividends

Jaguar Health Announces Series R Preferred Stock Conversion

Neutral
Nov 3, 2026

On October 15, 2026, Jaguar Health, Inc. paid a one-time dividend of one Series R Convertible Preferred Stock share for each outstanding voting common share and each share issuable under eligible warrants, based on holders at October 13, 2026.On Nove...

Business Operations and StrategyRegulatory Filings and ComplianceShareholder Meetings

Jaguar Animal Health Expands Stock Incentive Plan Proposal

Neutral
Oct 28, 2026

On October 8, 2026, Jaguar Health filed a definitive proxy statement ahead of a November 6, 2026 special shareholder meeting and has now supplemented it to expand Proposal 3, which seeks approval to amend and restate the 2014 Stock Incentive Plan. Th...

Business Operations and StrategyDividendsPrivate Placements and Financing

Jaguar Health Declares Special Series R Preferred Dividend

Positive
Oct 5, 2026

On September 30, 2026, Jaguar Health amended two $12 million royalty interest agreements with Uptown Capital and Streeterville Capital, pushing the start of monthly payments from October 1, 2026 to January 1, 2027 and setting a minimum monthly royalt...

Business Operations and StrategyPrivate Placements and Financing

Jaguar Animal Health Executes Major Debt-for-Equity Exchange

Neutral
Sep 25, 2026

On September 23, 2026, Jaguar Health entered privately negotiated exchange agreements with Streeterville Capital under which it issued 182,091 common shares to reduce by $1,678,320 the outstanding balance of a secured promissory note originally issue...

Business Operations and StrategyPrivate Placements and Financing

Jaguar Animal Health Reduces Debt Through Equity Exchange

Neutral
Sep 24, 2026

On November 12, 2025, Jaguar Health, Inc. issued a secured promissory note with an original principal amount of $10.81 million to Streeterville Capital, LLC under a note purchase agreement between the parties. The note formed part of the company’s br...

Business Operations and StrategyRegulatory Filings and ComplianceStock Split

Jaguar Animal Health Announces Major Equity Recapitalization

Neutral
Sep 21, 2026

On September 15, 2026, Jaguar Health filed a Certificate of Elimination in Delaware to remove multiple previously designated preferred stock series from its charter, returning those shares to authorized but undesignated preferred stock after all such...

Business Operations and StrategyM&A TransactionsPrivate Placements and Financing

Jaguar Animal Health expands ownership and restructures equity

Negative
Sep 15, 2026

On September 11, 2026, Jaguar Health exchanged a 6% convertible promissory note held by Lincoln Alternative Strategies for 557,377 shares of common stock, cancelling the $175,016.36 note balance and further shifting its liabilities into equity. Betwe...

Delistings and Listing ChangesRegulatory Filings and ComplianceShareholder MeetingsStock Split

Jaguar Animal Health Announces Reverse Stock Split Plans

Neutral
Sep 15, 2026

Jaguar Health, Inc. is a biopharmaceutical company that develops novel proprietary prescription drugs sustainably derived from plants for patients with complicated gastrointestinal disease states. Through its subsidiaries Napo Pharmaceuticals and Nap...

Business Operations and StrategyShareholder Meetings

Jaguar Health Faces Shareholder Quorum Challenge at Meeting

Negative
Sep 4, 2026

On September 4, 2026, Jaguar Health convened a special meeting of stockholders but failed to secure a quorum of voting common and Series Q preferred shares, preventing any votes or business from being conducted. The company stated it will not reconve...

Glossary
BuyA stock rated as a "Buy" is expected to perform better than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock is likely to deliver higher returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
HoldA stock rated as a "Hold" is expected to perform in line with the overall market or a specific benchmark. This rating indicates that the stock is neither particularly compelling nor unfavorable for investment. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
SellA stock rated as a "Sell" is expected to perform worse than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock may deliver lower returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.

Disclaimer

This AI Analyst Stock Report is automatically generated by our AI systems using advanced algorithms and publicly available financial, technical, and market data. While the information provided aims to be accurate and insightful, it is intended for informational purposes only and should not be considered financial advice. Any content created by an AI (Artificial Intelligence) system may contain inaccuracies and/or contain errors. Investing in stocks carries inherent risks, and past performance is not indicative of future results. This report does not account for your personal financial circumstances, objectives, or risk tolerance. Always conduct your own research or consult with a qualified financial advisor before making investment decisions. The analysis and recommendations provided are based on historical and current data and may not fully reflect future market conditions or unexpected developments. Neither the creators of this report nor its affiliated entities guarantee the accuracy, completeness, or reliability of the information presented. Use this report at your own discretion and risk.

Date of analysis: Nov 02, 2026