TipRanks
Go Ultimate55% OFF

Opko Health (OPK) AI Stock Analysis

IL:OPK

Opko Health

(TASE:OPK)

Rating:―N/A
Action:N/A
Date:―

No summary available

Positive Factors
Pharmaceutical Revenue GrowthStrong pharmaceutical growth indicates improving demand, commercial execution, and product contribution within OPKO’s higher-value business. If international volumes and RAYALDEE economics remain favorable, this segment can provide a more durable growth engine and help offset pressure in diagnostics.
Negative Factors
Persistent Losses and Weak MarginsOPKO’s revenue rebound has not yet translated into sustainable profitability, with materially negative operating and net margins. Continued losses reduce internally generated capital, make the business more dependent on financing or asset proceeds, and leave earnings power vulnerable if growth or reimbursement progress slows.

Opko Health (OPK) vs. iShares MSCI Israel ETF (EIS)

-40%-30%-20%-10%0%10%20%30%40%IL:OPK+9.84%EIS+13.14%Dec '25Jan '26Feb '26Mar '26Apr '26May '26Jun '26Jul '26Aug '26Sep '26Oct '26
Market Cap
ILS 1.24B
Dividend Yield
―
Average Volume (3M)
367.80K
Price to Earnings (P/E)
-17.0
Beta (1Y)
0.28
Revenue Growth
-23.21%
EPS Growth
64.08%
Country
Israel
Employees
2,275
Sector
Healthcare
Sector Strength
51
Industry
Medical - Diagnostics & Research

Opko Health Business Overview & Revenue Model

Company Description

OPKO Health, Inc. operates as a healthcare enterprise with a dual focus on diagnostics and pharmaceuticals. Its operations span the United States, Ireland, Chile, Spain, Israel, Mexico, and other international markets. The company's Diagnostics divis...

Opko Health Earnings Call Summary

Earnings Call Date:Jul 26, 2026(Q2-2026)|% Change Since:35.17%|Next Earnings Date:Nov 03, 2026
Earnings Call SentimentPositive

The call conveyed materially positive operational and financial momentum: substantial pipeline progress across ModeX and OPKO biologics, significant revenue growth in the Pharmaceutical segment, a stronger cash position (> $300M), improved consolidated results (much smaller net loss) and upgraded full-year revenue guidance. However, the company faces near-term headwinds including a year-over-year decline in diagnostics revenue tied to prior divestitures, elevated and persistent operating and R&D expenses, timing/reimbursement uncertainty for 4Kscore expansion, and clinical data/enrollment timing risks. Overall, the positive items (cash runway, pipeline advances, large revenue inflection items and much improved profitability metrics) outweigh the lowlights, but several execution and timing risks warrant monitoring.

Positive Updates

Robust cash position and shareholder returns
Ended Q2 with over $300 million in cash, cash equivalents and restricted cash; repurchased 9.7 million shares for approximately $13 million during the quarter and have ~ $94 million remaining authorization to repurchase additional shares.

Negative Updates

Diagnostics revenue decline due to prior divestiture and test mix changes
Diagnostics revenue fell to $74.5 million in Q2 2026 from $101.1 million in Q2 2025 (≈ -26.3% year-over-year), primarily reflecting the September 2025 sale (Labcorp transaction) and shifting certain higher-priced/esoteric tests to partners.

Company Guidance

OPKO guided Q3 2026 revenue of $131–142 million, including services revenue of $75–78 million, pharmaceutical product revenue of $40–44 million and IP & other revenue of $16–20 million (including Pfizer profit share of $8–10 million); Q3 total costs and expenses are expected to be $180–190 million with R&D of $34–38 million (partially offset by $5–7 million in BARDA and other collaboration funding) and depreciation & amortization of ~ $22 million. For full-year 2026 the company raised revenue guidance to $560–585 million (services $296–306 million; pharma product $164–174 million; partner collaboration/other $100–105 million, including Pfizer profit share $34–37 million), lowered total costs & expenses to $710–740 million, plans R&D of $125–135 million (offset by $18–22 million of BARDA funding and Regeneron reimbursements) and expects depreciation & amortization of ~ $95 million. The company also reported a Q2 cash balance of over $300 million, repurchased 9.7 million shares for ~ $13 million in the quarter and has approximately $94 million in remaining share repurchase authorization.

Opko Health Risk Analysis

Opko Health disclosed 54 risk factors in its most recent earnings report. Opko Health reported the most risks in the "Legal & Regulatory" category.

Higher RiskSector Avg.Lower RiskFinance & CorporateTech & InnovationLegal & RegulatoryProductionAbility to SellMacro & Political
Legal & Regulatory - Litigation, compliance, new legislation, and taxation risks

Latest Risks Added

0 New Risks

Opko Health Peers Comparison

Overall Rating

UnderperformOutperform
Sector (51)

Financial Indicators

IL:OPK against its peers
NameOverall RatingMarket CapP/E RatioROEDividend YieldRevenue GrowthEPS Growth
CSTLCSTL70Outperform$1.14B-56.34-4.15%―3.18%-100.37%
NEONEO54Neutral$2.25B-70.42-3.97%―11.08%71.76%
MYGNMYGN52Neutral$607.38M-5.32-32.59%―-3.16%72.02%
Sector *51Neutral$7.86B-0.30-43.30%2.27%22.53%-2.21%
FLGTFLGT50Neutral$567.37M-7.31-7.87%―6.83%-69.59%
MDXHMDXH46Neutral$15.58M-0.28142.63%―12.75%16.23%

* Healthcare Sector Average

Performance Comparison

-50%0%50%100%IL:OPKMYGNNEOFLGTMDXHCSTLDec '25Jan '26Feb '26Mar '26Apr '26May '26Jun '26Jul '26Aug '26Sep '26Oct '26
IL:OPK and its peers over the selected period
Show on chartTickerCompany NamePriceChange% Change
IL:OPKOpko Health506.9062.9014.17%
MYGNMyriad Genetics6.35-1.83-22.37%
NEONeoGenomics Inc.17.387.6077.71%
FLGTFulgent Genetics20.62-2.49-10.77%
MDXHMdxhealth S.A.0.16-4.68-96.63%
CSTLCastle Biosciences37.1611.1742.98%
Glossary
BuyA stock rated as a "Buy" is expected to perform better than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock is likely to deliver higher returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
HoldA stock rated as a "Hold" is expected to perform in line with the overall market or a specific benchmark. This rating indicates that the stock is neither particularly compelling nor unfavorable for investment. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
SellA stock rated as a "Sell" is expected to perform worse than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock may deliver lower returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.

Disclaimer

This AI Analyst Stock Report is automatically generated by our AI systems using advanced algorithms and publicly available financial, technical, and market data. While the information provided aims to be accurate and insightful, it is intended for informational purposes only and should not be considered financial advice. Any content created by an AI (Artificial Intelligence) system may contain inaccuracies and/or contain errors. Investing in stocks carries inherent risks, and past performance is not indicative of future results. This report does not account for your personal financial circumstances, objectives, or risk tolerance. Always conduct your own research or consult with a qualified financial advisor before making investment decisions. The analysis and recommendations provided are based on historical and current data and may not fully reflect future market conditions or unexpected developments. Neither the creators of this report nor its affiliated entities guarantee the accuracy, completeness, or reliability of the information presented. Use this report at your own discretion and risk.