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Physiomics (PYC) AI Stock Analysis

GB:PYC

Physiomics

(LSE:PYC)

Select Model
Rating:41.5Neutral
Price Target:GBX 0.41â–¼(-4.24% Downside)
Action:reiterated
Date:10/30/26

The score is driven primarily by weak financial performance (persistent losses, deteriorating recent revenue, and ongoing cash burn), with additional pressure from bearish technical signals (price below key moving averages, negative MACD, very low RSI). Valuation is not supportive because the company is loss-making (negative P/E) and no dividend yield is provided.

Positive Factors
Specialist computational modelling offeringThe company provides specialist systems biology and pharmacology modelling rather than undifferentiated services. This technical focus can support durable client value by helping drug developers interpret data, understand disease mechanisms, and predict drug behaviour.
Negative Factors
Persistent unprofitable operationsThe business has not demonstrated that revenue covers direct and operating costs, with losses persisting across the reported period. Continued negative profitability weakens internally generated capital, limits self-funded growth, and raises pressure to secure further funding.

Physiomics (PYC) vs. iShares MSCI United Kingdom ETF (EWC)

-40%-20%0%20%40%60%80%GB:PYC+2.41%EWC+21.27%Dec '25Jan '26Feb '26Mar '26Apr '26May '26Jun '26Jul '26Aug '26Sep '26Oct '26
Market Cap
GBP 1.43M
Dividend Yield
―
Average Volume (3M)
3.20M
Price to Earnings (P/E)
-2.1
Beta (1Y)
0.56
Revenue Growth
20.05%
EPS Growth
-11.11%
Country
UK
Employees
11
Sector
Healthcare
Sector Strength
51
Industry
Biotechnology

Physiomics Business Overview & Revenue Model

Company Description

Founded in 2001 and headquartered in Oxford, UK, Physiomics Plc offers expert consulting services to pharmaceutical enterprises across the United Kingdom, the United States, and the European Union. The company's core specialization lies in outsourced...

Physiomics Financial Statement Overview

Summary

Overall financial profile is weak: consistently loss-making with negative gross profit and deeply negative operating profitability, volatile revenue with a sharp latest-year decline, and sustained negative operating/free cash flow indicating ongoing funding needs. The main offset is very low leverage (minimal debt), which reduces near-term balance-sheet risk despite declining equity.

Income Statement

18Very Negative

Balance Sheet

52Neutral

Cash Flow

25Negative
Financial statement breakdown
BreakdownTTMJun 2025Jun 2024Jun 2023Jun 2022Jun 2021
Income Statement
Total Revenue941.22K941.22K784.00K543.25K597.35K830.27K
Gross Profit-801.20K-797.20K-435.08K-677.43K-581.62K-429.01K
EBITDA-792.31K-788.31K-448.21K-659.80K-561.57K-347.84K
Net Income-697.03K-697.03K-415.25K-609.35K-477.26K-253.14K
Balance Sheet
Total Assets788.55K788.55K892.03K422.60K674.39K1.12M
Cash, Cash Equivalents and Short-Term Investments418.63K418.63K461.24K191.07K416.59K687.67K
Total Debt0003,8257,3540
Total Liabilities264.57K264.57K199.85K140.08K142.67K140.61K
Stockholders Equity523.98K523.98K692.17K282.53K531.72K974.81K
Cash Flow
Free Cash Flow-566.17K-566.17K-550.08K-565.44K-271.50K-358.62K
Operating Cash Flow-561.74K-561.74K-546.14K-548.13K-264.86K-349.25K
Investing Cash Flow-4,426-4,426-3,413-15.21K-6,219-9,370
Financing Cash Flow523.56K523.56K819.73K337.83K02,845

Physiomics Technical Analysis

Technical Analysis SentimentNegative
Last Price0.42

Price Trends

50DMA0.50Negative
100DMA0.50Negative
200DMA0.50Negative

Market Momentum

MACD-0.02Positive
RSI12.97Positive
STOCH37.14Neutral

Evaluating momentum and price trends is crucial in stock analysis to make informed investment decisions. For GB:PYC, the sentiment is Negative. The current price of 0.42 is below the 20-day moving average (MA) of 0.48, below the 50-day MA of 0.50, and below the 200-day MA of 0.50, indicating a bearish trend. The MACD of -0.02 indicates Positive momentum. The RSI at 12.97 is Positive, neither overbought nor oversold. The STOCH value of 37.14 is Neutral, not indicating any strong overbought or oversold conditions. Overall, these indicators collectively point to a Negative sentiment for GB:PYC.

Physiomics Peers Comparison

Overall Rating

UnderperformOutperform
Sector (51)

Financial Indicators

GB:PYC against its peers
NameOverall RatingMarket CapP/E RatioROEDividend YieldRevenue GrowthEPS Growth
GB:IXIGB:IXI64NeutralGBP 25.73M-5.99-16.18%―13.04%15.88%
Sector *51Neutral$7.86B-0.30-43.30%2.27%22.53%-2.21%
GB:TCFGB:TCF42NeutralGBP 4.64M-1.70-93.92%――55.56%
GB:VALGB:VAL42NeutralGBP 2.24M-0.89-71.49%―-34.36%57.45%
GB:PYCGB:PYC42NeutralGBP 1.93M-2.13-152.03%―20.05%-11.11%
GB:OPTIGB:OPTI41NeutralGBP 5.99M-1.40-77.85%―11.90%-2864.29%
GB:OBDGB:OBD40UnderperformGBP 14.45M-0.27-451.74%―33.37%86.41%

* Healthcare Sector Average

Performance Comparison

-50%0%50%GB:PYCGB:TCFGB:IXIGB:OPTIGB:OBDGB:VALDec '25Jan '26Feb '26Mar '26Apr '26May '26Jun '26Jul '26Aug '26Sep '26Oct '26
GB:PYC and its peers over the selected period
Show on chartTickerCompany NamePriceChange% Change
GB:PYCPhysiomics plc0.420.000.00%
GB:TCFEvgen Pharma0.17-0.04-19.05%
GB:IXIIXICO plc11.750.252.17%
GB:OPTIOptiBiotix Health5.80-2.20-27.50%
GB:OBDOxford BioDynamics0.11-0.21-66.56%
GB:VALValiRx plc0.17-0.07-30.61%

Physiomics Corporate Events

Business Operations and StrategyFinancial Disclosures

Physiomics Wins New MIDD Contract as Recent Awards Surpass Annual Revenue

Positive
Oct 20, 2026

Physiomics plc, a specialist in model-informed drug development and quantitative pharmacology, has secured a new £102,000 contract for MIDD work incorporating pharmacokinetic and pharmacodynamic modelling. The company, whose client base includes...

Business Operations and StrategyFinancial Disclosures

Physiomics Wins £119k Modelling Contract and Explores New Markets for Dosing Tech

Positive
Oct 14, 2026

Physiomics has secured a new £119,000 contract for model-informed drug development work that includes pharmacokinetic and pharmacodynamic modelling, underlining demand for its quantitative expertise in supporting therapeutic development. Managem...

Business Operations and StrategyExecutive/Board ChangesFinancial DisclosuresPrivate Placements and Financing

Physiomics posts record income, expands biometrics amid higher one-off costs

Neutral
Oct 13, 2026

Physiomics reported record total income of £1.06 million for the year to 30 June 2026, up 26.5% and its best performance since inception, driven by strong Modelling & Simulation work and first-time revenue from its new Biometrics service lin...

Business Operations and StrategyExecutive/Board ChangesFinancial Disclosures

Physiomics’ Contract Wins Highlight Commercial Shift and Growth Momentum

Positive
Sep 10, 2026

Physiomics has secured new contracts worth more than £205,000, bringing total awards over just four months to above £750,000 and nearing the company’s full-year 2024-2025 revenue. The wins span its complementary service lines and refl...

Other

Investor Robert McFadden Builds 3.02% Stake in Physiomics

Positive
Aug 21, 2026

Physiomics plc, a UK-based provider of advanced modelling, data science and biostatistics services to the pharmaceutical and biotechnology industries, supports drug development and personalised medicine through cutting-edge computational tools and it...

Glossary
BuyA stock rated as a "Buy" is expected to perform better than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock is likely to deliver higher returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
HoldA stock rated as a "Hold" is expected to perform in line with the overall market or a specific benchmark. This rating indicates that the stock is neither particularly compelling nor unfavorable for investment. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
SellA stock rated as a "Sell" is expected to perform worse than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock may deliver lower returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.

Disclaimer

This AI Analyst Stock Report is automatically generated by our AI systems using advanced algorithms and publicly available financial, technical, and market data. While the information provided aims to be accurate and insightful, it is intended for informational purposes only and should not be considered financial advice. Any content created by an AI (Artificial Intelligence) system may contain inaccuracies and/or contain errors. Investing in stocks carries inherent risks, and past performance is not indicative of future results. This report does not account for your personal financial circumstances, objectives, or risk tolerance. Always conduct your own research or consult with a qualified financial advisor before making investment decisions. The analysis and recommendations provided are based on historical and current data and may not fully reflect future market conditions or unexpected developments. Neither the creators of this report nor its affiliated entities guarantee the accuracy, completeness, or reliability of the information presented. Use this report at your own discretion and risk.

Date of analysis: Oct 30, 2026