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Valerio Therapeutics (ALVIO) AI Stock Analysis

FR:ALVIO

Valerio Therapeutics

(Paris:ALVIO)

Select Model
Rating:43Neutral
Price Target:EUR 0.40â–¼(-6.93% Downside)
Action:reiterated
Date:10/03/26

The score is driven mainly by the 2025 operational turnaround in revenue, margins and cash generation, but capped by ongoing net losses and a fragile balance sheet, with weak, oversold technical momentum and lack of valuation support from earnings or dividends reinforcing a cautious overall view.

Positive Factors
Revenue RecoveryThe sharp 2025 revenue rebound indicates improving activity across Valerio Therapeutics’ development programs after a stagnant prior year. If maintained, stronger revenue can support research investment, improve operating leverage, and provide a more durable base for future partnering or financing opportunities.
Negative Factors
Persistent Net LossesValerio Therapeutics remains loss-making despite the 2025 revenue improvement, showing that current activities have not yet produced consistent earnings power. Continued net losses can consume capital, limit financial resilience, and require additional funding before oncology programs generate substantial partnering or commercial returns.

Valerio Therapeutics (ALVIO) vs. iShares MSCI France ETF (EWQ)

-100%0%100%200%300%400%500%600%FR:ALVIO+264.29%EWQ-0.37%Dec '25Jan '26Feb '26Mar '26Apr '26May '26Jun '26Jul '26Aug '26Sep '26Oct '26
Market Cap
EUR 269.62M
Dividend Yield
―
Average Volume (3M)
917.64K
Price to Earnings (P/E)
-10.1
Beta (1Y)
-0.26
Revenue Growth
203.22%
EPS Growth
62.89%
Country
France
Employees
41
Sector
Healthcare
Sector Strength
51
Industry
Biotechnology

Valerio Therapeutics Business Overview & Revenue Model

Company Description

Headquartered in Paris, France, and founded in 1997, Valerio Therapeutics S.A. (known as Onxeo SA until June 2023) is a clinical-stage biotechnology company dedicated to the global research and development of oncology treatments. Their focus is on ta...

How the Company Makes Money

As a clinical-stage biotechnology company, Valerio Therapeutics’ monetization primarily depends on external financing and potential partnering economics tied to its drug-development programs. The company generally generates cash through (1) capital r...

Valerio Therapeutics Financial Statement Overview

Summary

Revenue grew 41% in 2025 with stable 67–71% gross margins and EBITDA turning positive, but persistent net losses, high leverage and volatile cash flows keep overall financial strength modest.

Income Statement

45Neutral

Balance Sheet

35Negative

Cash Flow

55Neutral
Financial statement breakdown
BreakdownTTMDec 2025Jun 2025Dec 2023Dec 2022Dec 2021
Income Statement
Total Revenue5.55M2.57M1.79M1.80M1.44M4.06M
Gross Profit3.49M1.73M1.28M1.27M929.00K3.69M
EBITDA-1.31M542.00K-12.06M-19.68M-17.08M-5.86M
Net Income-7.05M-4.90M-23.93M-20.34M-19.56M-5.94M
Balance Sheet
Total Assets18.09M15.23M17.93M35.27M43.09M53.06M
Cash, Cash Equivalents and Short-Term Investments656.00K1.05M1.18M6.82M14.59M17.89M
Total Debt12.84M7.61M13.44M9.00M10.09M9.94M
Total Liabilities18.33M13.16M26.19M20.47M20.82M20.12M
Stockholders Equity-233.00K2.08M-8.93M14.80M22.27M32.94M
Cash Flow
Free Cash Flow3.04M521.00K-12.78M-18.78M-9.93M-8.71M
Operating Cash Flow4.76M1.84M-12.46M-18.60M-9.44M-8.57M
Investing Cash Flow-1.71M-1.16M-1.39M-177.00K-409.00K-66.00K
Financing Cash Flow-5.03M-774.00K4.21M10.76M6.46M11.98M

Valerio Therapeutics Technical Analysis

Technical Analysis SentimentPositive
Last Price0.43

Price Trends

50DMA0.57Negative
100DMA0.55Negative
200DMA0.35Positive

Market Momentum

MACD-0.03Negative
RSI48.32Neutral
STOCH67.78Neutral

Evaluating momentum and price trends is crucial in stock analysis to make informed investment decisions. For FR:ALVIO, the sentiment is Positive. The current price of 0.43 is above the 20-day moving average (MA) of 0.43, below the 50-day MA of 0.57, and above the 200-day MA of 0.35, indicating a neutral trend. The MACD of -0.03 indicates Negative momentum. The RSI at 48.32 is Neutral, neither overbought nor oversold. The STOCH value of 67.78 is Neutral, not indicating any strong overbought or oversold conditions. Overall, these indicators collectively point to a Positive sentiment for FR:ALVIO.

Valerio Therapeutics Peers Comparison

Overall Rating

UnderperformOutperform
Sector (51)

Financial Indicators

FR:ALVIO against its peers
NameOverall RatingMarket CapP/E RatioROEDividend YieldRevenue GrowthEPS Growth
Sector *51Neutral$7.86B-0.30-43.30%2.27%22.53%-2.21%
FR:IPHFR:IPH47NeutralEUR 140.30M-2.46152.56%―-29.48%7.91%
FR:TNGFR:TNG45NeutralEUR 202.03M-4.34-29.36%―189.81%38.50%
FR:ALVIOFR:ALVIO43NeutralEUR 269.62M-10.08-765.58%―203.22%62.89%
FR:OSEFR:OSE43NeutralEUR 45.93M-1.16-96.73%―-96.25%-197.89%
FR:SIGHTFR:SIGHT43NeutralEUR 18.98M-1.0652.39%―-610.31%43.88%
FR:ALCLSFR:ALCLS43NeutralEUR 75.07M-1.78-94.14%―-5.98%-8.67%

* Healthcare Sector Average

Performance Comparison

0%200%400%600%800%FR:ALVIOFR:IPHFR:TNGFR:OSEFR:SIGHTFR:ALCLSDec '25Jan '26Feb '26Mar '26Apr '26May '26Jun '26Jul '26Aug '26Sep '26Oct '26
FR:ALVIO and its peers over the selected period
Show on chartTickerCompany NamePriceChange% Change
FR:ALVIOValerio Therapeutics0.460.36373.20%
FR:IPHInnate Pharma S.A.1.26-0.35-21.79%
FR:TNGTransgene SA0.73-0.75-50.78%
FR:OSEOSE Immunotherapeutics1.95-3.78-65.93%
FR:SIGHTGenSight Biologics0.08-0.06-42.11%
FR:ALCLSCellectis SA1.04-1.90-64.69%

Valerio Therapeutics Corporate Events

Valerio Therapeutics Completes Etherna Deal to Build Integrated RNA Platform

Oct 12, 2026

Valerio Therapeutics has completed the acquisition of Etherna Immunotherapies, taking full control of the mRNA and lipid nanoparticle specialist to create a combined platform in targeted nucleic acid medicines. The deal, based on a €30 million...

Valerio Therapeutics accelerates RNA precision pivot with Etherna deal and new CEO

Oct 7, 2026

Valerio Therapeutics reported that the first half of 2026 was pivotal in its strategic refocus toward RNA‑based precision therapies, highlighted by the operational launch of InVimmune, a new subsidiary for in vivo cell therapy with an initial o...

Valerio Therapeutics to Acquire Etherna and Raises €40.25m in PIPE to Fund RNA Push

Aug 24, 2026

Valerio Therapeutics has signed a definitive agreement to acquire 100% of Etherna Immunotherapies NV for an enterprise value of €30 million, to be paid in cash and shares. The deal is intended to merge Etherna’s RNA and lipid nanoparticle...

Valerio Therapeutics Nears Signing of €30 Million Etherna Acquisition

Aug 17, 2026

Valerio Therapeutics has provided an update on its project to acquire 100% of Etherna Immunotherapies NV, following a binding offer made on July 1, 2026 that valued the target at an enterprise value of €30 million. The companies had initially s...

Glossary
BuyA stock rated as a "Buy" is expected to perform better than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock is likely to deliver higher returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
HoldA stock rated as a "Hold" is expected to perform in line with the overall market or a specific benchmark. This rating indicates that the stock is neither particularly compelling nor unfavorable for investment. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
SellA stock rated as a "Sell" is expected to perform worse than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock may deliver lower returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.

Disclaimer

This AI Analyst Stock Report is automatically generated by our AI systems using advanced algorithms and publicly available financial, technical, and market data. While the information provided aims to be accurate and insightful, it is intended for informational purposes only and should not be considered financial advice. Any content created by an AI (Artificial Intelligence) system may contain inaccuracies and/or contain errors. Investing in stocks carries inherent risks, and past performance is not indicative of future results. This report does not account for your personal financial circumstances, objectives, or risk tolerance. Always conduct your own research or consult with a qualified financial advisor before making investment decisions. The analysis and recommendations provided are based on historical and current data and may not fully reflect future market conditions or unexpected developments. Neither the creators of this report nor its affiliated entities guarantee the accuracy, completeness, or reliability of the information presented. Use this report at your own discretion and risk.

Date of analysis: Oct 03, 2026