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Ionis Pharmaceuticals (ISI) Financial Statements

Ionis Pharmaceuticals Financial Overview

Ionis Pharmaceuticals's market cap is currently $6.45B. The company's EPS TTM is $-3.46; its P/E ratio is -12.58; Ionis Pharmaceuticals is estimated to report earnings on November 4, 2026, and the estimated EPS forecast is $-1.09. See an overview of income statement, balance sheet, and cash flow financials.

Financial overview
Dec 25Dec 24Dec 23Dec 22Dec 21
Income Statement
Total Revenue$ 944.00M$ 705.14M$ 787.65M$ 587.37M$ 810.46M
Gross Profit$ 928.00M$ 693.92M$ 778.51M$ 573.25M$ 799.61M
Operating Income$ -382.00M$ -475.08M$ -353.73M$ -410.19M$ -30.19M
EBITDA$ -284.31M$ -353.72M$ -235.87M$ -227.76M$ -5.19M
Net Income$ -381.00M$ -453.90M$ -366.29M$ -269.72M$ -28.60M
Balance Sheet
Cash & Short-Term Investments$ 2.68B$ 2.30B$ 2.33B$ 2.00B$ 2.13B
Total Assets$ 3.52B$ 3.00B$ 2.99B$ 2.53B$ 2.61B
Total Debt$ 2.61B$ 1.42B$ 1.45B$ 1.37B$ 1.25B
Net Debt$ 2.24B$ 1.17B$ 1.05B$ 1.09B$ 381.86M
Total Liabilities$ 3.03B$ 2.42B$ 2.60B$ 1.96B$ 1.84B
Stockholders' Equity$ 489.09M$ 588.35M$ 386.69M$ 572.89M$ 771.74M
Cash Flow
Free Cash Flow$ -320.03M$ -546.23M$ -335.52M$ -294.47M$ 12.90M
Operating Cash Flow$ -268.58M$ -500.95M$ -307.51M$ -274.37M$ 30.80M
Investing Cash Flow$ -277.78M$ -134.03M$ -214.13M$ -262.64M$ 194.91M
Financing Cash Flow$ 675.84M$ 478.06M$ 644.08M$ -55.30M$ 245.93M

Currency in USD

Ionis Pharmaceuticals Earnings and Revenue History

-800M0800M1.6B-120 %-60 %0 %60 %EarningsProfit Margin201720182019202020212022202320242025RevenueEarningsProfit Margin

Ionis Pharmaceuticals Debt to Assets

01.5B3B4.5B45 %60 %75 %90 %LiabilitiesDebt to Assets201720182019202020212022202320242025AssetsLiabilitiesDebt to Assets

Ionis Pharmaceuticals Cash Flow

-1.5B-1B-500M0500M1B201720182019202020212022202320242025OperatingInvestingFinancing

Ionis Pharmaceuticals Forecast EPS vs Actual EPS

-2-101Q2 25Q3 25Q4 25Q1 26Q2 26Q3 26EPS EstimateBeatMiss