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Calidi Biotherapeutics (CLDI) AI Stock Analysis

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CLDI

Calidi Biotherapeutics

(NYSE MKT:CLDI)

Select Model
Rating:39Underperform
Price Target:$0.59â–¼(-5.48% Downside)
Action:reiterated
Date:11/14/26

Calidi Biotherapeutics carries severe investment risk primarily driven by its complete lack of commercial revenue, significant cash drain, and immediate NYSE delisting threats. While promising preclinical trial data and recent debt reductions show fundamental progress, aggressively bearish technical indicators and the constant need for dilutive capital raises currently dominate the stock's overall profile.

Positive Factors
Promising preclinical efficacyThe reported preclinical results provide meaningful validation for CLD-401 and Calidi’s therapeutic platform, including activity through both intravenous and intratumoral delivery. If replicated in further studies, this efficacy could support clinical advancement and strengthen partnering potential.
Negative Factors
No meaningful commercial revenueCalidi remains a pre-commercial biotechnology company without meaningful product revenue to offset research and operating expenses. Persistent losses and negative profitability mean future progress depends on successful clinical development and eventual commercialization rather than an established recurring revenue base.

Calidi Biotherapeutics (CLDI) vs. SPDR S&P 500 ETF (SPY)

-100%-75%-50%-25%0%25%CLDI-97.40%SPY+14.55%Dec '25Jan '26Feb '26Mar '26Apr '26May '26Jun '26Jul '26Aug '26Sep '26Oct '26Nov '26
Market Cap
$1.69M
Dividend Yield
―
Average Volume (3M)
108.65K
Price to Earnings (P/E)
-0.0
Beta (1Y)
1.01
Revenue Growth
―
EPS Growth
53.95%
Country
US
Employees
29
Sector
Healthcare
Sector Strength
51
Industry
Biotechnology

Calidi Biotherapeutics Business Overview & Revenue Model

Company Description

Calidi Biotherapeutics, Inc. is a clinical-stage biotechnology company focused on immuno-oncology, dedicated to developing advanced immunotherapies for various cancers. The company's innovative approach centers on utilizing powerful, allogeneic (dono...

How the Company Makes Money

Calidi Biotherapeutics is a clinical-stage biopharmaceutical company and, as such, it generally does not generate meaningful recurring revenue from product sales until a therapy is approved and commercialized. Specific, company-reported revenue break...

Calidi Biotherapeutics Financial Statement Overview

Summary

Calidi generates no commercial revenue and suffers from severe operational cash burn, with free cash flow at negative $17.8 million over the trailing twelve months. Despite commendable debt reductions, the company's small asset base and massive unprofitability pose significant liquidity risks.

Income Statement

15Very Negative

Balance Sheet

35Negative

Cash Flow

15Very Negative
Financial statement breakdown
BreakdownTTMDec 2025Mar 2025Dec 2023Dec 2022Dec 2021
Income Statement
Total Revenue000045.00K449.00K
Gross Profit-426.00K-1.65M0-1.26M-229.00K355.00K
EBITDA-15.62M-18.19M-19.73M-24.20M-25.00M-9.45M
Net Income-17.47M-19.91M-22.14M-29.22M-25.43M-10.93M
Balance Sheet
Total Assets7.20M8.86M14.18M10.02M2.60M3.39M
Cash, Cash Equivalents and Short-Term Investments4.07M5.60M9.59M2.05M372.00K2.14M
Total Debt1.94M2.56M7.04M7.24M5.99M5.18M
Total Liabilities4.07M5.10M12.21M18.25M53.04M26.00M
Stockholders Equity3.13M3.76M1.53M-8.23M-50.44M-22.61M
Cash Flow
Free Cash Flow-17.81M-21.41M-19.71M-27.57M-13.64M-7.98M
Operating Cash Flow-17.75M-21.29M-19.69M-26.98M-13.21M-7.77M
Investing Cash Flow-144.00K-170.00K-16.00K-478.00K-494.00K-215.00K
Financing Cash Flow16.81M17.46M27.36M29.04M12.09M9.81M

Calidi Biotherapeutics Technical Analysis

Technical Analysis SentimentNegative
Last Price0.62

Price Trends

50DMA0.96Negative
100DMA1.38Negative
200DMA3.73Negative

Market Momentum

MACD-0.08Negative
RSI34.94Neutral
STOCH27.20Neutral

Evaluating momentum and price trends is crucial in stock analysis to make informed investment decisions. For CLDI, the sentiment is Negative. The current price of 0.62 is below the 20-day moving average (MA) of 0.70, below the 50-day MA of 0.96, and below the 200-day MA of 3.73, indicating a bearish trend. The MACD of -0.08 indicates Negative momentum. The RSI at 34.94 is Neutral, neither overbought nor oversold. The STOCH value of 27.20 is Neutral, not indicating any strong overbought or oversold conditions. Overall, these indicators collectively point to a Negative sentiment for CLDI.

Calidi Biotherapeutics Risk Analysis

Calidi Biotherapeutics disclosed 85 risk factors in its most recent earnings report. Calidi Biotherapeutics reported the most risks in the "Tech & Innovation" category.

Higher RiskSector Avg.Lower RiskFinance & CorporateTech & InnovationLegal & RegulatoryProductionAbility to SellMacro & Political
Tech & Innovation - Risks related to the company’s reliance on technology and ability to make innovative products

Latest Risks Added

3 New Risks
1.The price of our stock may be volatile, which could result in substantial losses for investors. Further, an active, liquid and orderly trading market for our common stock may not be sustained, and we do not know what the market price of our common stock will be, and as a result it may be difficult for you to sell your shares of our common stock.Q4, 2023
2.The Sponsor, Metric, anchor investors and other investors purchased or received as an inducement to facilitate the Business Combination the Sponsor Shares that were acquired by the Sponsor, Metric or anchor investors at $0.004 per share price which is significantly below the current market price of a share of our common stock and such holder could sell their shares and generate a significant profit while causing the trading price of our common stock to decline significantly.Q4, 2023
3.The sale and resale of all shares of common stock registered on a Form S-1 represents approximately 65.7% of our outstanding shares and such resale could result in a significant decline in the public trading price of our common stock.Q4, 2023

Calidi Biotherapeutics Peers Comparison

Overall Rating

UnderperformOutperform
Sector (51)

Financial Indicators

CLDI against its peers
NameOverall RatingMarket CapP/E RatioROEDividend YieldRevenue GrowthEPS Growth
Sector *51Neutral$7.86B-0.30-43.30%2.27%22.53%-2.21%
CLDICLDI39Underperform$2.41M-0.03-372.86%――53.95%
JAGXJAGX37Underperform$5.34M0.00762.51%―135.52%85.50%

* Healthcare Sector Average

Performance Comparison

-100%-50%0%50%100%CLDIJAGXCDIODec '25Jan '26Feb '26Mar '26Apr '26May '26Jun '26Jul '26Aug '26Sep '26Oct '26Nov '26
CLDI and its peers over the selected period
Show on chartTickerCompany NamePriceChange% Change
CLDICalidi Biotherapeutics, Inc.0.62-23.38-97.41%
JAGXJaguar Animal Health Inc.0.42-685.01-99.94%
CDIOCardio Diagnostics Holdings Inc.1.89-1.10-36.79%

Calidi Biotherapeutics Corporate Events

Financial DisclosuresPrivate Placements and FinancingProduct-Related Announcements

Calidi Biotherapeutics Reports Third-Quarter 2026 Financial Results

Positive
Nov 13, 2026

Calidi Biotherapeutics reported third-quarter 2026 results on November 13, 2026, including a $3.6 million net loss attributable to common stockholders versus $10.8 million a year earlier; the prior-year figure included a $5.7 million non-cash deemed-...

Delistings and Listing ChangesRegulatory Filings and Compliance

Calidi Biotherapeutics Addresses NYSE American Compliance Notice

Negative
Sep 25, 2026

On September 21, 2026, Calidi Biotherapeutics received a notification from NYSE American that it was no longer in compliance with the exchange’s continued listing standard requiring at least $4.0 million in stockholders’ equity for companies with mul...

Business Operations and StrategyPrivate Placements and FinancingRegulatory Filings and Compliance

Calidi Biotherapeutics Announces Registered Direct Stock Offering

Positive
Sep 22, 2026

On September 17, 2026, Calidi Biotherapeutics, Inc. entered into a stock purchase agreement with accredited investors and qualified institutional buyers for a registered direct offering of 1,025,640 shares of common stock at $1.17 per share. The offe...

Glossary
BuyA stock rated as a "Buy" is expected to perform better than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock is likely to deliver higher returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
HoldA stock rated as a "Hold" is expected to perform in line with the overall market or a specific benchmark. This rating indicates that the stock is neither particularly compelling nor unfavorable for investment. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
SellA stock rated as a "Sell" is expected to perform worse than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock may deliver lower returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.

Disclaimer

This AI Analyst Stock Report is automatically generated by our AI systems using advanced algorithms and publicly available financial, technical, and market data. While the information provided aims to be accurate and insightful, it is intended for informational purposes only and should not be considered financial advice. Any content created by an AI (Artificial Intelligence) system may contain inaccuracies and/or contain errors. Investing in stocks carries inherent risks, and past performance is not indicative of future results. This report does not account for your personal financial circumstances, objectives, or risk tolerance. Always conduct your own research or consult with a qualified financial advisor before making investment decisions. The analysis and recommendations provided are based on historical and current data and may not fully reflect future market conditions or unexpected developments. Neither the creators of this report nor its affiliated entities guarantee the accuracy, completeness, or reliability of the information presented. Use this report at your own discretion and risk.

Date of analysis: Nov 13, 2026