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Calidi Biotherapeutics (CLDI) AI Stock Analysis

CLDI

Calidi Biotherapeutics

(NYSE MKT:CLDI)

Select Model
Rating:37Underperform
Price Target:$0.62â–¼(-7.92% Downside)
Action:reiterated
Date:10/20/26

The stock scores at the minimum due to severe fundamental and technical weakness. The company is pre-revenue with high cash burn and faces an NYSE compliance issue, while the stock price is in a deep downtrend with oversold, bearish momentum. Recent financing and pipeline progress are overshadowed by immediate financial and listing risks.

Positive Factors
Regulatory advancementFDA feedback on CMC, non-clinical plans, and trial design gives Calidi a clearer path toward human testing for CLD-401. This reduces development uncertainty and may help focus capital and research resources on advancing a defined clinical candidate.
Negative Factors
Pre-commercial lossesCalidi remains dependent on financing or other external capital because it has no meaningful product revenue and continues to convert operations into substantial cash outflows. Persistent losses and burn limit financial flexibility and could constrain the pace of pipeline development.

Calidi Biotherapeutics (CLDI) vs. SPDR S&P 500 ETF (SPY)

-100%-75%-50%-25%0%25%CLDI-97.26%SPY+12.58%Dec '25Jan '26Feb '26Mar '26Apr '26May '26Jun '26Jul '26Aug '26Sep '26Oct '26Nov '26
Market Cap
$1.78M
Dividend Yield
―
Average Volume (3M)
130.90K
Price to Earnings (P/E)
-0.0
Beta (1Y)
1.24
Revenue Growth
―
EPS Growth
53.95%
Country
US
Employees
29
Sector
Healthcare
Sector Strength
51
Industry
Biotechnology

Calidi Biotherapeutics Business Overview & Revenue Model

Company Description

Calidi Biotherapeutics, Inc. is a clinical-stage biotechnology company focused on immuno-oncology, dedicated to developing advanced immunotherapies for various cancers. The company's innovative approach centers on utilizing powerful, allogeneic (dono...

How the Company Makes Money

Calidi Biotherapeutics is a clinical-stage biopharmaceutical company and, as such, it generally does not generate meaningful recurring revenue from product sales until a therapy is approved and commercialized. Specific, company-reported revenue break...

Calidi Biotherapeutics Financial Statement Overview

Summary

Pre-revenue with persistent net losses and high cash burn, though losses are narrowing and the balance sheet shows modest improvement with positive equity and low debt. Overall financial health remains very weak for a clinical-stage biotech.

Income Statement

15Very Negative

Balance Sheet

30Negative

Cash Flow

22Negative
Financial statement breakdown
BreakdownTTMDec 2025Mar 2025Dec 2023Dec 2022Dec 2021
Income Statement
Total Revenue000045.00K449.00K
Gross Profit-426.00K-1.65M0-1.26M-229.00K355.00K
EBITDA-15.62M-18.19M-19.73M-24.20M-25.00M-9.45M
Net Income-17.47M-19.91M-22.14M-29.22M-25.43M-10.93M
Balance Sheet
Total Assets7.20M8.86M14.18M10.02M2.60M3.39M
Cash, Cash Equivalents and Short-Term Investments4.07M5.60M9.59M2.05M372.00K2.14M
Total Debt1.94M2.56M7.04M7.24M5.99M5.18M
Total Liabilities4.07M5.10M12.21M18.25M53.04M26.00M
Stockholders Equity3.13M3.76M1.53M-8.23M-50.44M-22.61M
Cash Flow
Free Cash Flow-17.81M-21.41M-19.71M-27.57M-13.64M-7.98M
Operating Cash Flow-17.75M-21.29M-19.69M-26.98M-13.21M-7.77M
Investing Cash Flow-144.00K-170.00K-16.00K-478.00K-494.00K-215.00K
Financing Cash Flow16.81M17.46M27.36M29.04M12.09M9.81M

Calidi Biotherapeutics Technical Analysis

Technical Analysis SentimentNegative
Last Price0.67

Price Trends

50DMA1.06Negative
100DMA1.52Negative
200DMA4.35Negative

Market Momentum

MACD-0.13Negative
RSI26.38Positive
STOCH29.60Neutral

Evaluating momentum and price trends is crucial in stock analysis to make informed investment decisions. For CLDI, the sentiment is Negative. The current price of 0.67 is below the 20-day moving average (MA) of 0.81, below the 50-day MA of 1.06, and below the 200-day MA of 4.35, indicating a bearish trend. The MACD of -0.13 indicates Negative momentum. The RSI at 26.38 is Positive, neither overbought nor oversold. The STOCH value of 29.60 is Neutral, not indicating any strong overbought or oversold conditions. Overall, these indicators collectively point to a Negative sentiment for CLDI.

Calidi Biotherapeutics Risk Analysis

Calidi Biotherapeutics disclosed 85 risk factors in its most recent earnings report. Calidi Biotherapeutics reported the most risks in the "Tech & Innovation" category.

Higher RiskSector Avg.Lower RiskFinance & CorporateTech & InnovationLegal & RegulatoryProductionAbility to SellMacro & Political
Tech & Innovation - Risks related to the company’s reliance on technology and ability to make innovative products

Latest Risks Added

0 New Risks

Calidi Biotherapeutics Peers Comparison

Overall Rating

UnderperformOutperform
Sector (51)

Financial Indicators

CLDI against its peers
NameOverall RatingMarket CapP/E RatioROEDividend YieldRevenue GrowthEPS Growth
Sector *51Neutral$7.86B-0.30-43.30%2.27%22.53%-2.21%
JAGXJAGX42Neutral$3.76M0.00762.51%―135.52%85.50%
ADILADIL40Underperform$10.00M-0.30-1693.21%――45.78%
CLDICLDI37Underperform$2.53M-0.01-372.86%――53.95%

* Healthcare Sector Average

Performance Comparison

-100%-50%0%50%CLDIJAGXADILCDIODec '25Jan '26Feb '26Mar '26Apr '26May '26Jun '26Jul '26Aug '26Sep '26Oct '26Nov '26
CLDI and its peers over the selected period
Show on chartTickerCompany NamePriceChange% Change
CLDICalidi Biotherapeutics, Inc.0.66-23.34-97.26%
JAGXJaguar Animal Health Inc.0.88-637.08-99.86%
ADILAdial Pharma3.81-4.32-53.15%
CDIOCardio Diagnostics Holdings Inc.1.67-1.95-53.87%

Calidi Biotherapeutics Corporate Events

Delistings and Listing ChangesRegulatory Filings and Compliance

Calidi Biotherapeutics Addresses NYSE American Compliance Notice

Negative
Sep 25, 2026

On September 21, 2026, Calidi Biotherapeutics received a notification from NYSE American that it was no longer in compliance with the exchange’s continued listing standard requiring at least $4.0 million in stockholders’ equity for compan...

Business Operations and StrategyPrivate Placements and FinancingRegulatory Filings and Compliance

Calidi Biotherapeutics Announces Registered Direct Stock Offering

Positive
Sep 22, 2026

On September 17, 2026, Calidi Biotherapeutics, Inc. entered into a stock purchase agreement with accredited investors and qualified institutional buyers for a registered direct offering of 1,025,640 shares of common stock at $1.17 per share. The offe...

Business Operations and StrategyExecutive/Board ChangesFinancial DisclosuresRegulatory Filings and Compliance

Calidi Biotherapeutics Reports Quarterly Results and Pipeline Progress

Positive
Aug 13, 2026

On August 13, 2026, Calidi Biotherapeutics reported financial results for the quarter ended June 30, 2026, alongside operational updates that underscore progress in its RedTail virotherapy platform. The company received positive pre-IND feedback from...

Glossary
BuyA stock rated as a "Buy" is expected to perform better than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock is likely to deliver higher returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
HoldA stock rated as a "Hold" is expected to perform in line with the overall market or a specific benchmark. This rating indicates that the stock is neither particularly compelling nor unfavorable for investment. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
SellA stock rated as a "Sell" is expected to perform worse than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock may deliver lower returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.

Disclaimer

This AI Analyst Stock Report is automatically generated by our AI systems using advanced algorithms and publicly available financial, technical, and market data. While the information provided aims to be accurate and insightful, it is intended for informational purposes only and should not be considered financial advice. Any content created by an AI (Artificial Intelligence) system may contain inaccuracies and/or contain errors. Investing in stocks carries inherent risks, and past performance is not indicative of future results. This report does not account for your personal financial circumstances, objectives, or risk tolerance. Always conduct your own research or consult with a qualified financial advisor before making investment decisions. The analysis and recommendations provided are based on historical and current data and may not fully reflect future market conditions or unexpected developments. Neither the creators of this report nor its affiliated entities guarantee the accuracy, completeness, or reliability of the information presented. Use this report at your own discretion and risk.

Date of analysis: Oct 20, 2026