Drug Development SetbacksThe discontinuation of HepTcell, a T cell immunotherapy for hepatitis B, due to insufficient response in Phase 2 trials may negatively impact the company's research pipeline and investor confidence.
Drug Tolerance And SafetyLimited safety data from the NASH trial indicates survodutide appears to be harder to tolerate than pemvidutide, potentially affecting patient adherence and treatment success.
Market CompetitionThe emergence of other effective weight loss therapies could pose additional risk to the company's ability to find a strategic partner for pemvidutide, pressuring its market positioning and revenue potential.