Skye Bioscience launches Phase 2 CBeyond trial of nimacimab

Skye Bioscience has started screening patients for a Phase 2 clinical trial of its novel peripheral CB1 inhibitor, nimacimab, a negative allosteric modulating antibody. The study will assess the ability of nimacimab as a next-generation weight loss therapeutic to safely and effectively reduce weight in patients with obesity. “There is clearly a need for alternative mechanisms of action that can provide physicians and patients with improved overall health outcomes in the pursuit of weight loss beyond those achieved with GLP-1 and GIP drugs. We believe that peripheral CB1 inhibition, and nimacimab, a unique biologic drug within the class, have attributes that may help provide such outcomes, and we look forward to our goals of reporting interim data from this Phase 2 obesity trial in Q2 of 2025 and final data in Q4 of 2025,” said Punit Dhillon, Chief Executive Officer of Skye. “CB1 inhibition research has shown its potential to directly promote energy expenditure and fat breakdown1, improve leptin sensitivity, and peripherally modulate hunger and satiety 3. We are pleased to be assessing nimacimab as a monotherapy but to also undertake a preliminary evaluation of our peripheral CB1 inhibitor in combination with a GLP-1 drug.”