Seelos Therapeutics reports preclinical data from an in vivo study of SLS-005

Seelos Therapeutics announced encouraging preclinical data from an in vivo study of SLS-005 in an aggressive Alzheimer’s disease non-human primate model. Seelos has been selected to present a poster of these data at Neuroscience 2023 to be held on November 11-15, 2023 in Washington, D.C. In this study, the overexpression of tau in older non-human primates (NHPs) was utilized through bilateral AAV induced tauopathy. NHPs in this study were administered either SLS-005 weekly, a single administration of SLS-009 or control. The NHPs receiving SLS-005 demonstrated a 46% reduction in tau protein and an 18% reduction in NfL (neurofilament light chain) protein biomarker from baseline values in a preliminary analysis. NfL is a non-specific biomarker for several neurodegenerative conditions, including Alzheimer’s disease, multiple sclerosis, and amyotrophic lateral sclerosis, or ALS. Additionally, top-line data from the SLS-005 registrational Phase II/III trial in ALS as part of the HEALEY ALS Platform Trial led by Harvard Medical School at Massachusetts General Hospital is expected to be released in the Q4.