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Sagimet Biosciences to present Phase 2b FASCINATE-2 study results

Sagimet Biosciences (SGMT) announced that analyses of the Phase 2b FASCINATE-2 study showing that denifanstat elicited fibrosis improvement in patients with advanced fibrosis will be presented at the American Association for the Study of Liver Disease – The Liver Meeting 2025, taking place November 7-11, 2025 in Washington, DC. The analysis showed denifanstat’s robust anti-fibrotic effect as measured by both conventional and AI-based digital pathology. AI-based digital pathology was utilized to identify a subpopulation of MASH patients with advanced baseline fibrosis and enabled the observation that denifanstat reduced fibrosis and improved multiple non-invasive test biomarkers associated with the primary drivers of MASH in this subgroup.

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